NUCB2 — 45 ClinVar variants
All ClinVar germline NUCB2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
1 Likely benign · 44 Uncertain significance
Full NUCB2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 35
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NUCB2 p.Ala161Thr Uncertain significance Single submitter
- NUCB2 p.Ala161Val Uncertain significance Single submitter
- NUCB2 p.Ala21Val Uncertain significance Single submitter
- NUCB2 p.Ala43Glu Uncertain significance Single submitter
- NUCB2 p.Ala43Val Uncertain significance Single submitter
- NUCB2 p.Arg108Lys Uncertain significance Single submitter
- NUCB2 p.Asn352Ser Uncertain significance Single submitter
- NUCB2 p.Asp148Glu Uncertain significance Single submitter
- NUCB2 p.Asp254Glu Uncertain significance Single submitter
- NUCB2 p.Asp366Asn Uncertain significance Single submitter
- NUCB2 p.Asp63Asn Uncertain significance Single submitter
- NUCB2 p.Cys17Arg Uncertain significance Single submitter
- NUCB2 p.Gln340Arg Uncertain significance Single submitter
- NUCB2 p.Glu105Lys Uncertain significance Single submitter
- NUCB2 p.Glu110Gln Uncertain significance Single submitter
- NUCB2 p.Glu190Gln Uncertain significance Single submitter
- NUCB2 p.Glu208Asp Uncertain significance Single submitter
- NUCB2 p.Glu208Gln Uncertain significance Single submitter
- NUCB2 p.Glu23Gln Uncertain significance Single submitter
- NUCB2 p.Glu329Gln Uncertain significance Single submitter
- NUCB2 p.His174Pro Uncertain significance Single submitter
- NUCB2 p.Ile420Leu Uncertain significance Single submitter
- NUCB2 p.Leu103Pro Uncertain significance Single submitter
- NUCB2 p.Leu166Pro Uncertain significance Single submitter
- NUCB2 p.Leu269Pro Uncertain significance Single submitter
- NUCB2 p.Leu274Met Uncertain significance Single submitter
- NUCB2 p.Leu75Pro Uncertain significance Single submitter
- NUCB2 p.Lys213Glu Uncertain significance Single submitter
- NUCB2 p.Lys364Arg Uncertain significance Single submitter
- NUCB2 p.Lys44Asn Uncertain significance Single submitter
- NUCB2 p.Phe318Cys Uncertain significance Single submitter
- NUCB2 p.Ser164Gly Uncertain significance Single submitter
- NUCB2 p.Ser96Gly Uncertain significance Single submitter
- NUCB2 p.Tyr180Cys Uncertain significance Single submitter
- NUCB2 p.Val255Ile Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- NUCB2 p.Ala162Val Uncertain significance Single submitter
- NUCB2 p.Asp245Glu Uncertain significance Single submitter
- NUCB2 p.Glu185Ala Uncertain significance Single submitter
- NUCB2 p.Glu299Asp Uncertain significance Single submitter
- NUCB2 p.Glu323Gly Uncertain significance Single submitter
- NUCB2 p.Glu397Gly Uncertain significance Single submitter
- NUCB2 p.Lys348Thr Uncertain significance Single submitter
- NUCB2 p.Met157Ile Uncertain significance Single submitter
- NUCB2 p.Pro26Arg Uncertain significance Single submitter
All NUCB2 variants
Likely benign 1
- p.His38Gln Single submitter
Uncertain significance 44
- p.Ala161Thr Single submitter ⚠
- p.Ala161Val Single submitter ⚠
- p.Ala162Val Single submitter ⚠
- p.Ala21Val Single submitter ⚠
- p.Ala43Glu Single submitter ⚠
- p.Ala43Val Single submitter ⚠
- p.Arg108Lys Single submitter ⚠
- p.Asn352Ser Single submitter ⚠
- p.Asp148Glu Single submitter ⚠
- p.Asp245Glu Single submitter ⚠
- p.Asp254Glu Single submitter ⚠
- p.Asp366Asn Single submitter ⚠
- p.Asp63Asn Single submitter ⚠
- p.Cys17Arg Single submitter ⚠
- p.Gln340Arg Single submitter ⚠
- p.Glu105Lys Single submitter ⚠
- p.Glu110Gln Single submitter ⚠
- p.Glu185Ala Single submitter ⚠
- p.Glu190Gln Single submitter ⚠
- p.Glu208Asp Single submitter ⚠
- p.Glu208Gln Single submitter ⚠
- p.Glu23Gln Single submitter ⚠
- p.Glu299Asp Single submitter ⚠
- p.Glu323Gly Single submitter ⚠
- p.Glu329Gln Single submitter ⚠
- p.Glu397Gly Single submitter ⚠
- p.His174Pro Single submitter ⚠
- p.Ile420Leu Single submitter ⚠
- p.Leu103Pro Single submitter ⚠
- p.Leu166Pro Single submitter ⚠
- p.Leu269Pro Single submitter ⚠
- p.Leu274Met Single submitter ⚠
- p.Leu75Pro Single submitter ⚠
- p.Lys213Glu Single submitter ⚠
- p.Lys348Thr Single submitter ⚠
- p.Lys364Arg Single submitter ⚠
- p.Lys44Asn Single submitter ⚠
- p.Met157Ile Single submitter ⚠
- p.Phe318Cys Single submitter ⚠
- p.Pro26Arg Single submitter ⚠
- p.Ser164Gly Single submitter ⚠
- p.Ser96Gly Single submitter ⚠
- p.Tyr180Cys Single submitter ⚠
- p.Val255Ile Single submitter ⚠