NUDC — 48 ClinVar variants
All ClinVar germline NUDC variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
1 Likely benign · 47 Uncertain significance
Full NUDC gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 33
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NUDC p.Ala184Ser Uncertain significance Single submitter
- NUDC p.Ala216Val Uncertain significance Single submitter
- NUDC p.Ala85Val Uncertain significance Single submitter
- NUDC p.Ala89Ser Uncertain significance Single submitter
- NUDC p.Arg204Trp Uncertain significance Single submitter
- NUDC p.Arg208Gln Uncertain significance Single submitter
- NUDC p.Arg256Cys Uncertain significance Single submitter
- NUDC p.Arg256His Uncertain significance Single submitter
- NUDC p.Arg70Gln Uncertain significance Single submitter
- NUDC p.Arg81Gln Uncertain significance Single submitter
- NUDC p.Arg82Gln Uncertain significance Single submitter
- NUDC p.Asp148Gly Uncertain significance Single submitter
- NUDC p.Asp168Tyr Uncertain significance Single submitter
- NUDC p.Asp305Glu Uncertain significance Single submitter
- NUDC p.Cys188Phe Uncertain significance Single submitter
- NUDC p.Gln26Arg Uncertain significance Single submitter
- NUDC p.Gln319Arg Uncertain significance Single submitter
- NUDC p.Glu150Ala Uncertain significance Single submitter
- NUDC p.Glu47Gly Uncertain significance Single submitter
- NUDC p.Glu80Lys Uncertain significance Single submitter
- NUDC p.Glu94Ala Uncertain significance Single submitter
- NUDC p.Gly135Ser Uncertain significance Single submitter
- NUDC p.His128Gln Uncertain significance Single submitter
- NUDC p.Ile218Val Uncertain significance Single submitter
- NUDC p.Ile44Phe Uncertain significance Single submitter
- NUDC p.Leu163Ile Uncertain significance Single submitter
- NUDC p.Lys96Thr Uncertain significance Single submitter
- NUDC p.Pro321Leu Uncertain significance Single submitter
- NUDC p.Ser100Leu Uncertain significance Single submitter
- NUDC p.Ser139Phe Uncertain significance Single submitter
- NUDC p.Ser232Leu Uncertain significance Single submitter
- NUDC p.Ser259Phe Uncertain significance Single submitter
- NUDC p.Thr99Ile Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- NUDC p.Ala328Thr Uncertain significance Single submitter
- NUDC p.Arg208Trp Uncertain significance Single submitter
- NUDC p.Arg295Gln Uncertain significance Single submitter
- NUDC p.Arg71Trp Uncertain significance Single submitter
- NUDC p.Arg81Trp Uncertain significance Single submitter
- NUDC p.Arg82Trp Uncertain significance Single submitter
- NUDC p.Asn249Ser Uncertain significance Single submitter
- NUDC p.Gly157Arg Uncertain significance Single submitter
- NUDC p.Gly238Cys Uncertain significance Single submitter
- NUDC p.Met299Val Uncertain significance Single submitter
- NUDC p.Phe59Leu Uncertain significance Single submitter
All NUDC variants
Likely benign 1
- p.Ile202= No assertion criteria NUDC-related condition
Uncertain significance 47
- p.Ala184Ser Single submitter ⚠
- p.Ala216Val Single submitter ⚠
- p.Ala328Thr Single submitter ⚠
- p.Ala85Val Single submitter ⚠
- p.Ala89Ser Single submitter ⚠
- p.Arg204Trp Single submitter ⚠
- p.Arg208Gln Single submitter ⚠
- p.Arg208Trp Single submitter ⚠
- p.Arg256Cys Single submitter ⚠
- p.Arg256His Single submitter ⚠
- p.Arg295Gln Single submitter ⚠
- p.Arg70Gln Single submitter ⚠
- p.Arg71Trp Single submitter ⚠
- p.Arg81Gln Single submitter ⚠
- p.Arg81Trp Single submitter ⚠
- p.Arg82Gln Single submitter ⚠
- p.Arg82Trp Single submitter ⚠
- p.Asn162Ser Single submitter
- p.Asn249Ser Single submitter ⚠
- p.Asp148Gly Single submitter ⚠
- p.Asp168Tyr Single submitter ⚠
- p.Asp305Glu Single submitter ⚠
- p.Cys188Phe Single submitter ⚠
- p.Gln26Arg Single submitter ⚠
- p.Gln319Arg Single submitter ⚠
- p.Glu150Ala Single submitter ⚠
- p.Glu47Gly Single submitter ⚠
- p.Glu80Lys Single submitter ⚠
- p.Glu94Ala Single submitter ⚠
- p.Gly135Ser Single submitter ⚠
- p.Gly157Arg Single submitter ⚠
- p.Gly238Cys Single submitter ⚠
- p.His128Gln Single submitter ⚠
- p.Ile218Val Single submitter ⚠
- p.Ile44Phe Single submitter ⚠
- p.Leu163Ile Single submitter ⚠
- p.Leu28Val Single submitter
- p.Lys96Thr Single submitter ⚠
- p.Met299Val Single submitter ⚠
- p.Phe59Leu Single submitter ⚠
- p.Pro186Leu Single submitter
- p.Pro321Leu Single submitter ⚠
- p.Ser100Leu Single submitter ⚠
- p.Ser139Phe Single submitter ⚠
- p.Ser232Leu Single submitter ⚠
- p.Ser259Phe Single submitter ⚠
- p.Thr99Ile Single submitter ⚠