NUDT14 — 40 ClinVar variants
All ClinVar germline NUDT14 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 34 flagged for review →
3 Likely benign · 37 Uncertain significance
Full NUDT14 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 34
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 12
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NUDT14 p.Ala140Ser Uncertain significance Single submitter
- NUDT14 p.Arg152Lys Uncertain significance Single submitter
- NUDT14 p.Arg165Cys Uncertain significance Single submitter
- NUDT14 p.Glu175Asp Uncertain significance Single submitter
- NUDT14 p.Glu88Lys Uncertain significance Single submitter
- NUDT14 p.Gly106Ser Uncertain significance Single submitter
- NUDT14 p.Gly95Ser Uncertain significance Single submitter
- NUDT14 p.Lys59Arg Uncertain significance Single submitter
- NUDT14 p.Pro168Thr Uncertain significance Single submitter
- NUDT14 p.Ser134Cys Uncertain significance Single submitter
- NUDT14 p.Val173Met Uncertain significance Single submitter
- NUDT14 p.Val81Gly Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- NUDT14 p.Ala189Ser Uncertain significance Single submitter
- NUDT14 p.Ala64Val Uncertain significance Single submitter
- NUDT14 p.Arg137Cys Uncertain significance Single submitter
- NUDT14 p.Arg165Pro Uncertain significance Single submitter
- NUDT14 p.Arg62Trp Uncertain significance Single submitter
- NUDT14 p.Arg72His Uncertain significance Single submitter
- NUDT14 p.Arg73Cys Uncertain significance Single submitter
- NUDT14 p.Asn49Ser Uncertain significance Single submitter
- NUDT14 p.Asp162Gly Uncertain significance Single submitter
- NUDT14 p.Cys120Arg Uncertain significance Single submitter
- NUDT14 p.Gly169Asp Uncertain significance Single submitter
- NUDT14 p.Gly203Ser Uncertain significance Single submitter
- NUDT14 p.His40Arg Uncertain significance Single submitter
- NUDT14 p.Leu107Phe Uncertain significance Single submitter
- NUDT14 p.Pro133His Uncertain significance Single submitter
- NUDT14 p.Pro196Leu Uncertain significance Single submitter
- NUDT14 p.Pro217Leu Uncertain significance Single submitter
- NUDT14 p.Pro91Leu Uncertain significance Single submitter
- NUDT14 p.Thr141Ile Uncertain significance Single submitter
- NUDT14 p.Thr149Ile Uncertain significance Single submitter
- NUDT14 p.Thr39Met Uncertain significance Single submitter
- NUDT14 p.Val204Ile Uncertain significance Single submitter
All NUDT14 variants
Likely benign 3
- p.Ala105= Single submitter
- p.Asp195Asn Single submitter
- p.Val45Ile Single submitter
Uncertain significance 37
- p.Ala140Ser Single submitter ⚠
- p.Ala189Ser Single submitter ⚠
- p.Ala64Val Single submitter ⚠
- p.Arg137Cys Single submitter ⚠
- p.Arg152Lys Single submitter ⚠
- p.Arg165Cys Single submitter ⚠
- p.Arg165Pro Single submitter ⚠
- p.Arg62Trp Single submitter ⚠
- p.Arg72His Single submitter ⚠
- p.Arg73Cys Single submitter ⚠
- p.Asn49Ser Single submitter ⚠
- p.Asp162Gly Single submitter ⚠
- p.Cys120Arg Single submitter ⚠
- p.Gln60Glu Single submitter
- p.Glu175Asp Single submitter ⚠
- p.Glu175Gly Single submitter
- p.Glu88Lys Single submitter ⚠
- p.Gly106Ser Single submitter ⚠
- p.Gly169Asp Single submitter ⚠
- p.Gly203Ser Single submitter ⚠
- p.Gly95Ser Single submitter ⚠
- p.His40Arg Single submitter ⚠
- p.Ile179Thr Single submitter
- p.Leu107Phe Single submitter ⚠
- p.Lys59Arg Single submitter ⚠
- p.Pro133His Single submitter ⚠
- p.Pro168Thr Single submitter ⚠
- p.Pro196Leu Single submitter ⚠
- p.Pro217Leu Single submitter ⚠
- p.Pro91Leu Single submitter ⚠
- p.Ser134Cys Single submitter ⚠
- p.Thr141Ile Single submitter ⚠
- p.Thr149Ile Single submitter ⚠
- p.Thr39Met Single submitter ⚠
- p.Val173Met Single submitter ⚠
- p.Val204Ile Single submitter ⚠
- p.Val81Gly Single submitter ⚠