NUDT15 — 22 ClinVar variants
All ClinVar germline NUDT15 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 11 flagged for review →
1 Benign · 6 Likely benign · 15 Uncertain significance
Full NUDT15 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 11
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 9
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NUDT15 p.Ala69Thr Uncertain significance Single submitter
- NUDT15 p.Glu63Lys Uncertain significance Single submitter
- NUDT15 p.Gly32Trp Uncertain significance Single submitter
- NUDT15 p.Gly48Val Uncertain significance Single submitter
- NUDT15 p.Gly9Trp Uncertain significance Single submitter
- NUDT15 p.His49Arg Uncertain significance Single submitter
- NUDT15 p.Val157Met Uncertain significance Single submitter
- NUDT15 p.Val29Ile Uncertain significance Single submitter
- NUDT15 p.Val38Leu Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All NUDT15 variants
Benign 1
- c.*7G>A No assertion criteria NUDT15-related disorder
Likely benign 6
Uncertain significance 15
- c.355+2T>A Single submitter NUDT15-related disorder
- p.13GV[4] Single submitter
- p.Ala69Thr Single submitter ⚠
- p.Cys28fs Single submitter
- p.Glu63Lys Single submitter ⚠
- p.Gly32Trp Single submitter ⚠
- p.Gly48Val Single submitter ⚠
- p.Gly9Trp Single submitter ⚠
- p.His25Pro Single submitter
- p.His49Arg Single submitter ⚠
- p.Ile95Thr Single submitter ⚠
- p.Pro26Gln Single submitter ⚠
- p.Val157Met Single submitter ⚠
- p.Val29Ile Single submitter ⚠
- p.Val38Leu Single submitter ⚠