NUDT21 — 7 ClinVar variants
All ClinVar germline NUDT21 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 5 flagged for review →
2 Benign · 5 Uncertain significance
Full NUDT21 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 5
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 3
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 2
The independent predictors disagree with each other — read with care.
All NUDT21 variants
Uncertain significance 5
- p.Arg15Trp Single submitter ⚠
- p.Gly16Glu Single submitter ⚠
- p.Ile128Val Single submitter ⚠
- p.Thr166Ile Single submitter ⚠
- p.Trp148Ser Single submitter ⚠