NUDT5 — 20 ClinVar variants
All ClinVar germline NUDT5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 18 flagged for review →
20 Uncertain significance
Full NUDT5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 18
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NUDT5 p.Ala129Val Uncertain significance Single submitter
- NUDT5 p.Ala153Thr Uncertain significance Single submitter
- NUDT5 p.Ala63Val Uncertain significance Single submitter
- NUDT5 p.Asn138Ile Uncertain significance Single submitter
- NUDT5 p.Gly135Asp Uncertain significance Single submitter
- NUDT5 p.Ile141Met Uncertain significance Single submitter
- NUDT5 p.Ile141Val Uncertain significance Single submitter
- NUDT5 p.Ile92Val Uncertain significance Single submitter
- NUDT5 p.Leu136Ser Uncertain significance Single submitter
- NUDT5 p.Met37Val Uncertain significance Single submitter
- NUDT5 p.Met87Ile Uncertain significance Single submitter
- NUDT5 p.Pro134Arg Uncertain significance Single submitter
- NUDT5 p.Pro211Ser Uncertain significance Single submitter
- NUDT5 p.Pro86Ser Uncertain significance Single submitter
- NUDT5 p.Ser24Ala Uncertain significance Single submitter
- NUDT5 p.Thr43Ile Uncertain significance Single submitter
- NUDT5 p.Thr7Met Uncertain significance Single submitter
- NUDT5 p.Trp46Ser Uncertain significance Single submitter
All NUDT5 variants
Uncertain significance 20
- p.Ala129Val Single submitter ⚠
- p.Ala153Thr Single submitter ⚠
- p.Ala63Val Single submitter ⚠
- p.Asn138His Single submitter
- p.Asn138Ile Single submitter ⚠
- p.Gly135Asp Single submitter ⚠
- p.Ile141Met Single submitter ⚠
- p.Ile141Val Single submitter ⚠
- p.Ile92Val Single submitter ⚠
- p.Leu136Ser Single submitter ⚠
- p.Met37Val Single submitter ⚠
- p.Met87Ile Single submitter ⚠
- p.Pro134Arg Single submitter ⚠
- p.Pro162Leu Single submitter
- p.Pro211Ser Single submitter ⚠
- p.Pro86Ser Single submitter ⚠
- p.Ser24Ala Single submitter ⚠
- p.Thr43Ile Single submitter ⚠
- p.Thr7Met Single submitter ⚠
- p.Trp46Ser Single submitter ⚠