NXF1 — 49 ClinVar variants
All ClinVar germline NXF1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
5 Likely benign · 44 Uncertain significance
Full NXF1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 32
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NXF1 p.Ala108Val Uncertain significance Single submitter
- NXF1 p.Ala240Ser Uncertain significance Single submitter
- NXF1 p.Ala254Ser Uncertain significance Single submitter
- NXF1 p.Arg332Gln Uncertain significance Single submitter
- NXF1 p.Arg38His Uncertain significance Single submitter
- NXF1 p.Arg42Lys Uncertain significance Single submitter
- NXF1 p.Arg82Gln Uncertain significance Single submitter
- NXF1 p.Arg82Trp Uncertain significance Single submitter
- NXF1 p.Arg97Trp Uncertain significance Single submitter
- NXF1 p.Asn37Thr Uncertain significance Single submitter
- NXF1 p.Asn80His Uncertain significance Single submitter
- NXF1 p.Asp84Gly Uncertain significance Single submitter
- NXF1 p.Gln160His Uncertain significance Single submitter
- NXF1 p.Gln208Glu Uncertain significance Single submitter
- NXF1 p.Gln601Glu Uncertain significance Single submitter
- NXF1 p.Glu583Gln Uncertain significance Single submitter
- NXF1 p.Gly44Ser Uncertain significance Single submitter
- NXF1 p.Gly504Arg Uncertain significance Single submitter
- NXF1 p.Ile150Val Uncertain significance Single submitter
- NXF1 p.Ile215Met Uncertain significance Single submitter
- NXF1 p.Lys446Arg Uncertain significance Single submitter
- NXF1 p.Lys471Arg Uncertain significance Single submitter
- NXF1 p.Pro358Leu Uncertain significance Single submitter
- NXF1 p.Ser116Leu Uncertain significance Single submitter
- NXF1 p.Ser40Phe Uncertain significance Single submitter
- NXF1 p.Ser9Gly Uncertain significance Single submitter
- NXF1 p.Thr368Met Uncertain significance Single submitter
- NXF1 p.Thr369Pro Uncertain significance Single submitter
- NXF1 p.Thr458Met Uncertain significance Single submitter
- NXF1 p.Thr85Pro Uncertain significance Single submitter
- NXF1 p.Val163Ile Uncertain significance Single submitter
- NXF1 p.Val476Ala Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- NXF1 p.Ala226Thr Uncertain significance Single submitter
- NXF1 p.Arg182Trp Uncertain significance Single submitter
- NXF1 p.Arg30Trp Uncertain significance Single submitter
- NXF1 p.Arg91Cys Uncertain significance Single submitter
- NXF1 p.Asn477Ile Uncertain significance Single submitter
- NXF1 p.Gln486Glu Uncertain significance Single submitter
- NXF1 p.Glu319Asp Uncertain significance Single submitter
- NXF1 p.Gly44Cys Uncertain significance Single submitter
- NXF1 p.Ile150Thr Uncertain significance Single submitter
- NXF1 p.Ser144Ile Uncertain significance Single submitter
- NXF1 p.Val245Ala Uncertain significance Single submitter
- NXF1 p.Val364Phe Uncertain significance Single submitter
All NXF1 variants
Likely benign 5
- p.Leu214Val Multiple submitters
- c.1761-4C>A Single submitter
- p.Ile200Val Single submitter
- p.Thr369Met Single submitter
- p.Tyr72= Single submitter
Uncertain significance 44
- p.Ala108Val Single submitter ⚠
- p.Ala226Thr Single submitter ⚠
- p.Ala240Ser Single submitter ⚠
- p.Ala254Ser Single submitter ⚠
- p.Arg182Trp Single submitter ⚠
- p.Arg30Trp Single submitter ⚠
- p.Arg332Gln Single submitter ⚠
- p.Arg38His Single submitter ⚠
- p.Arg42Lys Single submitter ⚠
- p.Arg82Gln Single submitter ⚠
- p.Arg82Trp Single submitter ⚠
- p.Arg91Cys Single submitter ⚠
- p.Arg97Trp Single submitter ⚠
- p.Asn37Thr Single submitter ⚠
- p.Asn477Ile Single submitter ⚠
- p.Asn80His Single submitter ⚠
- p.Asp84Gly Single submitter ⚠
- p.Gln160His Single submitter ⚠
- p.Gln208Glu Single submitter ⚠
- p.Gln486Glu Single submitter ⚠
- p.Gln601Glu Single submitter ⚠
- p.Glu319Asp Single submitter ⚠
- p.Glu583Gln Single submitter ⚠
- p.Gly44Cys Single submitter ⚠
- p.Gly44Ser Single submitter ⚠
- p.Gly504Arg Single submitter ⚠
- p.Ile150Thr Single submitter ⚠
- p.Ile150Val Single submitter ⚠
- p.Ile215Met Single submitter ⚠
- p.Lys446Arg Single submitter ⚠
- p.Lys471Arg Single submitter ⚠
- p.Pro358Leu Single submitter ⚠
- p.Ser116Leu Single submitter ⚠
- p.Ser144Ile Single submitter ⚠
- p.Ser40Phe Single submitter ⚠
- p.Ser9Gly Single submitter ⚠
- p.Thr368Met Single submitter ⚠
- p.Thr369Pro Single submitter ⚠
- p.Thr458Met Single submitter ⚠
- p.Thr85Pro Single submitter ⚠
- p.Val163Ile Single submitter ⚠
- p.Val245Ala Single submitter ⚠
- p.Val364Phe Single submitter ⚠
- p.Val476Ala Single submitter ⚠