OGA — 71 ClinVar variants
All ClinVar germline OGA variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 66 flagged for review →
1 Benign · 3 Likely benign · 67 Uncertain significance
Full OGA gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 66
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 60
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- OGA p.Ala25Pro Uncertain significance Single submitter
- OGA p.Ala25Val Uncertain significance Single submitter
- OGA p.Ala27Val Uncertain significance Single submitter
- OGA p.Ala33Val Uncertain significance Single submitter
- OGA p.Ala45Val Uncertain significance Single submitter
- OGA p.Ala490Val Uncertain significance Single submitter
- OGA p.Ala51Val Uncertain significance Single submitter
- OGA p.Ala53Thr Uncertain significance Single submitter
- OGA p.Arg108Gln Uncertain significance Single submitter
- OGA p.Arg156Cys Uncertain significance Single submitter
- OGA p.Arg586Gln Uncertain significance Single submitter
- OGA p.Arg59Gln Uncertain significance Single submitter
- OGA p.Arg608Gln Uncertain significance Single submitter
- OGA p.Arg874Trp Uncertain significance Single submitter
- OGA p.Asn534Asp Uncertain significance Single submitter
- OGA p.Asn543His Uncertain significance Single submitter
- OGA p.Asn838Ser Uncertain significance Single submitter
- OGA p.Asp367Val Uncertain significance Single submitter
- OGA p.Asp476Val Uncertain significance Single submitter
- OGA p.Gln163His Uncertain significance Single submitter
- OGA p.Gln3His Uncertain significance Single submitter
- OGA p.Gln3Leu Uncertain significance Single submitter
- OGA p.Gln559His Uncertain significance Single submitter
- OGA p.Glu132Gln Uncertain significance Single submitter
- OGA p.Glu258Asp Uncertain significance Single submitter
- OGA p.Glu556Gly Uncertain significance Single submitter
- OGA p.Gly46Ala Uncertain significance Single submitter
- OGA p.Gly46Arg Uncertain significance Single submitter
- OGA p.Gly47Glu Uncertain significance Single submitter
- OGA p.Ile368Val Uncertain significance Single submitter
- OGA p.Ile487Thr Uncertain significance Single submitter
- OGA p.Ile506Leu Uncertain significance Single submitter
- OGA p.Ile636Val Uncertain significance Single submitter
- OGA p.Ile717Leu Uncertain significance Single submitter
- OGA p.Ile751Leu Uncertain significance Single submitter
- OGA p.Ile899Val Uncertain significance Single submitter
- OGA p.Leu29Val Uncertain significance Single submitter
- OGA p.Leu451Met Uncertain significance Single submitter
- OGA p.Leu451Val Uncertain significance Single submitter
- OGA p.Leu555Val Uncertain significance Single submitter
- OGA p.Leu564Ile Uncertain significance Single submitter
- OGA p.Lys713Arg Uncertain significance Single submitter
- OGA p.Met514Leu Uncertain significance Single submitter
- OGA p.Met845Val Uncertain significance Single submitter
- OGA p.Pro148Ser Uncertain significance Single submitter
- OGA p.Pro394Ser Uncertain significance Single submitter
- OGA p.Pro464Ser Uncertain significance Single submitter
- OGA p.Pro526Ala Uncertain significance Single submitter
- OGA p.Ser152Thr Uncertain significance Single submitter
- OGA p.Ser19Ala Uncertain significance Single submitter
- OGA p.Ser19Cys Uncertain significance Single submitter
- OGA p.Ser364Thr Uncertain significance Single submitter
- OGA p.Ser398Asn Uncertain significance Single submitter
- OGA p.Ser410Asn Uncertain significance Single submitter
- OGA p.Ser915Asn Uncertain significance Single submitter
- OGA p.Thr449Pro Uncertain significance Single submitter
- OGA p.Thr549Ala Uncertain significance Single submitter
- OGA p.Val276Ile Uncertain significance Single submitter
- OGA p.Val428Ile Uncertain significance Single submitter
- OGA p.Val714Ile Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- OGA p.Arg691His Uncertain significance Single submitter
- OGA p.Asp753His Uncertain significance Single submitter
- OGA p.Cys663Tyr Uncertain significance Single submitter
- OGA p.Glu239Gly Uncertain significance Single submitter
- OGA p.Met120Ile Uncertain significance Single submitter
- OGA p.Phe835Leu Uncertain significance Single submitter
All OGA variants
Benign 1
- c.200-7A>C Single submitter
Likely benign 3
- c.1037-3C>T Multiple submitters
- c.653-8A>G Single submitter
- p.Thr450Ala Single submitter
Uncertain significance 67
- p.Ala25Pro Single submitter ⚠
- p.Ala25Val Single submitter ⚠
- p.Ala27Val Single submitter ⚠
- p.Ala33Val Single submitter ⚠
- p.Ala45Val Single submitter ⚠
- p.Ala490Val Single submitter ⚠
- p.Ala51Val Single submitter ⚠
- p.Ala53Thr Single submitter ⚠
- p.Arg108Gln Single submitter ⚠
- p.Arg156Cys Single submitter ⚠
- p.Arg586Gln Single submitter ⚠
- p.Arg59Gln Single submitter ⚠
- p.Arg608Gln Single submitter ⚠
- p.Arg691His Single submitter ⚠
- p.Arg874Trp Single submitter ⚠
- p.Asn534Asp Single submitter ⚠
- p.Asn543His Single submitter ⚠
- p.Asn838Ser Single submitter ⚠
- p.Asp367Val Single submitter ⚠
- p.Asp476Val Single submitter ⚠
- p.Asp753His Single submitter ⚠
- p.Cys181Ter Single submitter
- p.Cys663Tyr Single submitter ⚠
- p.Gln163His Single submitter ⚠
- p.Gln3His Single submitter ⚠
- p.Gln3Leu Single submitter ⚠
- p.Gln559His Single submitter ⚠
- p.Glu132Gln Single submitter ⚠
- p.Glu239Gly Single submitter ⚠
- p.Glu258Asp Single submitter ⚠
- p.Glu556Gly Single submitter ⚠
- p.Gly46Ala Single submitter ⚠
- p.Gly46Arg Single submitter ⚠
- p.Gly47Glu Single submitter ⚠
- p.Ile368Val Single submitter ⚠
- p.Ile487Thr Single submitter ⚠
- p.Ile506Leu Single submitter ⚠
- p.Ile636Val Single submitter ⚠
- p.Ile717Leu Single submitter ⚠
- p.Ile751Leu Single submitter ⚠
- p.Ile899Val Single submitter ⚠
- p.Leu29Val Single submitter ⚠
- p.Leu451Met Single submitter ⚠
- p.Leu451Val Single submitter ⚠
- p.Leu555Val Single submitter ⚠
- p.Leu564Ile Single submitter ⚠
- p.Lys713Arg Single submitter ⚠
- p.Met120Ile Single submitter ⚠
- p.Met514Leu Single submitter ⚠
- p.Met845Val Single submitter ⚠
- p.Phe835Leu Single submitter ⚠
- p.Pro148Ser Single submitter ⚠
- p.Pro394Ser Single submitter ⚠
- p.Pro464Ser Single submitter ⚠
- p.Pro526Ala Single submitter ⚠
- p.Ser152Thr Single submitter ⚠
- p.Ser19Ala Single submitter ⚠
- p.Ser19Cys Single submitter ⚠
- p.Ser364Thr Single submitter ⚠
- p.Ser398Asn Single submitter ⚠
- p.Ser410Asn Single submitter ⚠
- p.Ser915Asn Single submitter ⚠
- p.Thr449Pro Single submitter ⚠
- p.Thr549Ala Single submitter ⚠
- p.Val276Ile Single submitter ⚠
- p.Val428Ile Single submitter ⚠
- p.Val714Ile Single submitter ⚠