OGFR — 125 ClinVar variants
All ClinVar germline OGFR variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 98 flagged for review →
1 Conflicting · 25 Likely benign · 99 Uncertain significance
Full OGFR gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 98
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 66
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- OGFR p.Ala253Val Uncertain significance Single submitter
- OGFR p.Ala411Thr Uncertain significance Single submitter
- OGFR p.Ala469Thr Uncertain significance Single submitter
- OGFR p.Ala480Val Uncertain significance Single submitter
- OGFR p.Ala655Thr Uncertain significance Single submitter
- OGFR p.Ala660Val Uncertain significance Single submitter
- OGFR p.Arg166Trp Uncertain significance Single submitter
- OGFR p.Arg206Cys Uncertain significance Single submitter
- OGFR p.Arg212Pro Uncertain significance Single submitter
- OGFR p.Arg234His Uncertain significance Single submitter
- OGFR p.Arg250Pro Uncertain significance Single submitter
- OGFR p.Arg328Gly Uncertain significance Single submitter
- OGFR p.Arg328Trp Uncertain significance Single submitter
- OGFR p.Arg348Gln Uncertain significance Single submitter
- OGFR p.Arg360Ser Uncertain significance Single submitter
- OGFR p.Arg373Thr Uncertain significance Single submitter
- OGFR p.Arg385Lys Uncertain significance Single submitter
- OGFR p.Arg391Gln Uncertain significance Single submitter
- OGFR p.Arg391Trp Uncertain significance Single submitter
- OGFR p.Arg444Cys Uncertain significance Single submitter
- OGFR p.Arg458Gln Uncertain significance Single submitter
- OGFR p.Arg507Gly Uncertain significance Single submitter
- OGFR p.Arg59Gly Uncertain significance Single submitter
- OGFR p.Arg67Gly Uncertain significance Single submitter
- OGFR p.Asn498Ser Uncertain significance Single submitter
- OGFR p.Asp2Gly Uncertain significance Single submitter
- OGFR p.Asp318Asn Uncertain significance Single submitter
- OGFR p.Asp3Tyr Uncertain significance Single submitter
- OGFR p.Cys443Ser Uncertain significance Single submitter
- OGFR p.Gln201His Uncertain significance Single submitter
- OGFR p.Gln477Lys Uncertain significance Single submitter
- OGFR p.Glu312Lys Uncertain significance Single submitter
- OGFR p.Glu322Ala Uncertain significance Single submitter
- OGFR p.Glu365Lys Uncertain significance Single submitter
- OGFR p.Glu41Gly Uncertain significance Single submitter
- OGFR p.Glu46Gln Uncertain significance Single submitter
- OGFR p.Glu505Gln Uncertain significance Single submitter
- OGFR p.Glu596Lys Uncertain significance Single submitter
- OGFR p.Gly327Asp Uncertain significance Single submitter
- OGFR p.Gly331Arg Uncertain significance Single submitter
- OGFR p.Gly331Glu Uncertain significance Single submitter
- OGFR p.Gly338Trp Uncertain significance Single submitter
- OGFR p.Gly368Asp Uncertain significance Single submitter
- OGFR p.Gly370Arg Uncertain significance Single submitter
- OGFR p.Gly422Val Uncertain significance Single submitter
- OGFR p.Gly483Arg Uncertain significance Single submitter
- OGFR p.Leu358Pro Uncertain significance Single submitter
- OGFR p.Lys673Gln Uncertain significance Single submitter
- OGFR p.Met60Arg Uncertain significance Single submitter
- OGFR p.Phe257Tyr Uncertain significance Single submitter
- OGFR p.Pro231Leu Uncertain significance Single submitter
- OGFR p.Pro247Arg Uncertain significance Single submitter
- OGFR p.Pro319Ser Uncertain significance Single submitter
- OGFR p.Pro345Ser Uncertain significance Single submitter
- OGFR p.Pro374Leu Uncertain significance Single submitter
- OGFR p.Pro379His Uncertain significance Single submitter
- OGFR p.Pro436Leu Uncertain significance Single submitter
- OGFR p.Ser324Arg Uncertain significance Single submitter
- OGFR p.Ser496Thr Uncertain significance Single submitter
- OGFR p.Ser517Arg Uncertain significance Single submitter
- OGFR p.Thr118Met Uncertain significance Single submitter
- OGFR p.Thr189Met Uncertain significance Single submitter
- OGFR p.Thr478Ile Uncertain significance Single submitter
- OGFR p.Thr508Met Uncertain significance Single submitter
- OGFR p.Tyr178Cys Uncertain significance Single submitter
- OGFR p.Val668Leu Uncertain significance Single submitter
Predictors split 32
The independent predictors disagree with each other — read with care.
- OGFR p.Ala627Val Uncertain significance Single submitter
- OGFR p.Arg192Gln Uncertain significance Single submitter
- OGFR p.Arg199Cys Uncertain significance Single submitter
- OGFR p.Arg264Gln Uncertain significance Single submitter
- OGFR p.Arg293Trp Uncertain significance Single submitter
- OGFR p.Arg605His Uncertain significance Single submitter
- OGFR p.Arg625His Uncertain significance Single submitter
- OGFR p.Asn210His Uncertain significance Single submitter
- OGFR p.Asp372Tyr Uncertain significance Single submitter
- OGFR p.Asp572His Uncertain significance Single submitter
- OGFR p.Glu155Gly Uncertain significance Single submitter
- OGFR p.Glu576Ala Uncertain significance Single submitter
- OGFR p.Glu580Asp Uncertain significance Single submitter
- OGFR p.Glu613Ala Uncertain significance Single submitter
- OGFR p.Gly551Arg Uncertain significance Single submitter
- OGFR p.Lys291Glu Uncertain significance Single submitter
- OGFR p.Lys386Glu Uncertain significance Single submitter
- OGFR p.Phe273Leu Uncertain significance Single submitter
- OGFR p.Pro534Leu Uncertain significance Single submitter
- OGFR p.Pro609Ser Uncertain significance Single submitter
- OGFR p.Pro624Ser Uncertain significance Single submitter
- OGFR p.Pro626Leu Uncertain significance Single submitter
- OGFR p.Pro644Thr Uncertain significance Single submitter
- OGFR p.Pro646Leu Uncertain significance Single submitter
- OGFR p.Ser420Arg Uncertain significance Single submitter
- OGFR p.Ser599Leu Conflicting Single submitter
- OGFR p.Ser619Leu Uncertain significance Single submitter
- OGFR p.Ser645Cys Uncertain significance Single submitter
- OGFR p.Ser674Tyr Uncertain significance Single submitter
- OGFR p.Thr187Met Uncertain significance Single submitter
- OGFR p.Thr561Ile Uncertain significance Single submitter
- OGFR p.Val249Met Uncertain significance Single submitter
All OGFR variants
Conflicting classifications of pathogenicity 1
- p.Ser599Leu Single submitter ⚠
Likely benign 25
- c.172-8C>G Single submitter
- p.Ala260Thr Single submitter
- p.Arg244Gln Single submitter
- p.Arg507Gln Single submitter
- p.Arg591Gly Single submitter
- p.Asp572= Single submitter
- p.Asp592= Single submitter
- p.Asp612= Single submitter
- p.Asp652= Single submitter
- p.Gln161Arg Single submitter
- p.Glu322Lys Single submitter
- p.Glu636_Ala655del Single submitter
- p.Gly563= Single submitter
- p.His265Asn Single submitter
- p.His334Arg Single submitter
- p.Leu167Phe Single submitter
- p.Lys511Glu Single submitter
- p.Pro538= Single submitter
- p.Pro546= Single submitter
- p.Pro558= Single submitter
- p.Pro578= Single submitter
- p.Pro586= Single submitter
- p.Pro606= Single submitter
- p.Thr514Ala Single submitter
- p.Thr91Met Single submitter
Uncertain significance 99
- p.Ala253Val Single submitter ⚠
- p.Ala411Thr Single submitter ⚠
- p.Ala469Thr Single submitter ⚠
- p.Ala480Val Single submitter ⚠
- p.Ala627Val Single submitter ⚠
- p.Ala655Thr Single submitter ⚠
- p.Ala660Val Single submitter ⚠
- p.Arg138Gln Single submitter
- p.Arg166Trp Single submitter ⚠
- p.Arg192Gln Single submitter ⚠
- p.Arg199Cys Single submitter ⚠
- p.Arg206Cys Single submitter ⚠
- p.Arg212Pro Single submitter ⚠
- p.Arg234His Single submitter ⚠
- p.Arg250Pro Single submitter ⚠
- p.Arg264Gln Single submitter ⚠
- p.Arg268Cys Single submitter
- p.Arg293Trp Single submitter ⚠
- p.Arg328Gly Single submitter ⚠
- p.Arg328Trp Single submitter ⚠
- p.Arg348Gln Single submitter ⚠
- p.Arg360Ser Single submitter ⚠
- p.Arg373Thr Single submitter ⚠
- p.Arg385Lys Single submitter ⚠
- p.Arg391Gln Single submitter ⚠
- p.Arg391Trp Single submitter ⚠
- p.Arg444Cys Single submitter ⚠
- p.Arg458Gln Single submitter ⚠
- p.Arg507Gly Single submitter ⚠
- p.Arg59Gly Single submitter ⚠
- p.Arg605His Single submitter ⚠
- p.Arg625His Single submitter ⚠
- p.Arg67Gly Single submitter ⚠
- p.Asn210His Single submitter ⚠
- p.Asn498Ser Single submitter ⚠
- p.Asp2Gly Single submitter ⚠
- p.Asp318Asn Single submitter ⚠
- p.Asp372Tyr Single submitter ⚠
- p.Asp3Tyr Single submitter ⚠
- p.Asp572His Single submitter ⚠
- p.Cys443Ser Single submitter ⚠
- p.Gln201His Single submitter ⚠
- p.Gln477Lys Single submitter ⚠
- p.Glu155Gly Single submitter ⚠
- p.Glu312Lys Single submitter ⚠
- p.Glu322Ala Single submitter ⚠
- p.Glu365Lys Single submitter ⚠
- p.Glu41Gly Single submitter ⚠
- p.Glu46Gln Single submitter ⚠
- p.Glu505Gln Single submitter ⚠
- p.Glu576Ala Single submitter ⚠
- p.Glu580Asp Single submitter ⚠
- p.Glu596Lys Single submitter ⚠
- p.Glu613Ala Single submitter ⚠
- p.Gly327Asp Single submitter ⚠
- p.Gly331Arg Single submitter ⚠
- p.Gly331Glu Single submitter ⚠
- p.Gly338Trp Single submitter ⚠
- p.Gly368Asp Single submitter ⚠
- p.Gly370Arg Single submitter ⚠
- p.Gly422Val Single submitter ⚠
- p.Gly483Arg Single submitter ⚠
- p.Gly551Arg Single submitter ⚠
- p.Leu358Pro Single submitter ⚠
- p.Lys291Glu Single submitter ⚠
- p.Lys386Glu Single submitter ⚠
- p.Lys673Gln Single submitter ⚠
- p.Met60Arg Single submitter ⚠
- p.Phe257Tyr Single submitter ⚠
- p.Phe273Leu Single submitter ⚠
- p.Pro231Leu Single submitter ⚠
- p.Pro247Arg Single submitter ⚠
- p.Pro319Ser Single submitter ⚠
- p.Pro345Ser Single submitter ⚠
- p.Pro374Leu Single submitter ⚠
- p.Pro379His Single submitter ⚠
- p.Pro436Leu Single submitter ⚠
- p.Pro534Leu Single submitter ⚠
- p.Pro609Ser Single submitter ⚠
- p.Pro624Ser Single submitter ⚠
- p.Pro626Leu Single submitter ⚠
- p.Pro644Thr Single submitter ⚠
- p.Pro646Leu Single submitter ⚠
- p.Ser324Arg Single submitter ⚠
- p.Ser420Arg Single submitter ⚠
- p.Ser496Thr Single submitter ⚠
- p.Ser517Arg Single submitter ⚠
- p.Ser619Leu Single submitter ⚠
- p.Ser645Cys Single submitter ⚠
- p.Ser674Tyr Single submitter ⚠
- p.Thr118Met Single submitter ⚠
- p.Thr187Met Single submitter ⚠
- p.Thr189Met Single submitter ⚠
- p.Thr478Ile Single submitter ⚠
- p.Thr508Met Single submitter ⚠
- p.Thr561Ile Single submitter ⚠
- p.Tyr178Cys Single submitter ⚠
- p.Val249Met Single submitter ⚠
- p.Val668Leu Single submitter ⚠