OGFRL1 — 43 ClinVar variants
All ClinVar germline OGFRL1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 40 flagged for review →
2 Likely benign · 41 Uncertain significance
Full OGFRL1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 40
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 36
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- OGFRL1 p.Arg298Gln Uncertain significance Single submitter
- OGFRL1 p.Arg316Gln Uncertain significance Single submitter
- OGFRL1 p.Arg316Gly Uncertain significance Single submitter
- OGFRL1 p.Asn154Ser Uncertain significance Single submitter
- OGFRL1 p.Asn337Lys Uncertain significance Single submitter
- OGFRL1 p.Asp435Glu Uncertain significance Single submitter
- OGFRL1 p.Cys444Arg Uncertain significance Single submitter
- OGFRL1 p.Gln319Arg Uncertain significance Single submitter
- OGFRL1 p.Glu308Lys Uncertain significance Single submitter
- OGFRL1 p.Glu427Lys Uncertain significance Single submitter
- OGFRL1 p.Glu437Ala Uncertain significance Single submitter
- OGFRL1 p.His336Tyr Uncertain significance Single submitter
- OGFRL1 p.His343Arg Uncertain significance Single submitter
- OGFRL1 p.Ile137Thr Uncertain significance Single submitter
- OGFRL1 p.Ile287Ser Uncertain significance Single submitter
- OGFRL1 p.Leu176Pro Uncertain significance Single submitter
- OGFRL1 p.Lys295Asn Uncertain significance Single submitter
- OGFRL1 p.Lys347Thr Uncertain significance Single submitter
- OGFRL1 p.Lys366Gln Uncertain significance Single submitter
- OGFRL1 p.Lys417Thr Uncertain significance Single submitter
- OGFRL1 p.Met342Ile Uncertain significance Single submitter
- OGFRL1 p.Phe194Ser Uncertain significance Single submitter
- OGFRL1 p.Phe204Leu Uncertain significance Single submitter
- OGFRL1 p.Phe205Ser Uncertain significance Single submitter
- OGFRL1 p.Pro331Leu Uncertain significance Single submitter
- OGFRL1 p.Pro391Ala Uncertain significance Single submitter
- OGFRL1 p.Pro89Thr Uncertain significance Single submitter
- OGFRL1 p.Ser335Arg Uncertain significance Single submitter
- OGFRL1 p.Ser341Tyr Uncertain significance Single submitter
- OGFRL1 p.Ser405Ala Uncertain significance Single submitter
- OGFRL1 p.Thr305Lys Uncertain significance Single submitter
- OGFRL1 p.Thr305Met Uncertain significance Single submitter
- OGFRL1 p.Tyr136His Uncertain significance Single submitter
- OGFRL1 p.Tyr179His Uncertain significance Single submitter
- OGFRL1 p.Tyr304His Uncertain significance Single submitter
- OGFRL1 p.Val140Ile Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All OGFRL1 variants
Likely benign 2
- p.Ala333Thr Single submitter
- p.Asn433Ser Single submitter
Uncertain significance 41
- p.Arg113Gln Single submitter ⚠
- p.Arg298Gln Single submitter ⚠
- p.Arg298Trp Single submitter
- p.Arg316Gln Single submitter ⚠
- p.Arg316Gly Single submitter ⚠
- p.Asn154Ser Single submitter ⚠
- p.Asn337Lys Single submitter ⚠
- p.Asp111Gly Single submitter ⚠
- p.Asp435Glu Single submitter ⚠
- p.Cys444Arg Single submitter ⚠
- p.Gln319Arg Single submitter ⚠
- p.Glu308Lys Single submitter ⚠
- p.Glu427Lys Single submitter ⚠
- p.Glu437Ala Single submitter ⚠
- p.His336Tyr Single submitter ⚠
- p.His343Arg Single submitter ⚠
- p.Ile137Thr Single submitter ⚠
- p.Ile287Ser Single submitter ⚠
- p.Leu176Pro Single submitter ⚠
- p.Lys295Asn Single submitter ⚠
- p.Lys347Thr Single submitter ⚠
- p.Lys366Gln Single submitter ⚠
- p.Lys417Thr Single submitter ⚠
- p.Lys90Thr Single submitter ⚠
- p.Met342Ile Single submitter ⚠
- p.Phe194Ser Single submitter ⚠
- p.Phe204Leu Single submitter ⚠
- p.Phe205Ser Single submitter ⚠
- p.Pro331Leu Single submitter ⚠
- p.Pro391Ala Single submitter ⚠
- p.Pro89Thr Single submitter ⚠
- p.Ser335Arg Single submitter ⚠
- p.Ser341Tyr Single submitter ⚠
- p.Ser405Ala Single submitter ⚠
- p.Thr305Lys Single submitter ⚠
- p.Thr305Met Single submitter ⚠
- p.Tyr136His Single submitter ⚠
- p.Tyr179His Single submitter ⚠
- p.Tyr304His Single submitter ⚠
- p.Val140Ile Single submitter ⚠
- p.Val284Leu Single submitter ⚠