OGN — 32 ClinVar variants
All ClinVar germline OGN variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 31 flagged for review →
1 Likely benign · 31 Uncertain significance
Full OGN gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 31
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- OGN p.Ala122Thr Uncertain significance Single submitter
- OGN p.Ala78Val Uncertain significance Single submitter
- OGN p.Arg127Gly Uncertain significance Single submitter
- OGN p.Arg202Lys Uncertain significance Single submitter
- OGN p.Arg237Cys Uncertain significance Single submitter
- OGN p.Arg264Trp Uncertain significance Single submitter
- OGN p.Arg28His Uncertain significance Single submitter
- OGN p.Asn67Lys Uncertain significance Single submitter
- OGN p.Asn67Ser Uncertain significance Single submitter
- OGN p.Asp149Asn Uncertain significance Single submitter
- OGN p.Asp157Glu Uncertain significance Single submitter
- OGN p.Asp160Gly Uncertain significance Single submitter
- OGN p.Asp252Asn Uncertain significance Single submitter
- OGN p.Asp32Gly Uncertain significance Single submitter
- OGN p.Asp89Val Uncertain significance Single submitter
- OGN p.Gly161Ser Uncertain significance Single submitter
- OGN p.His222Arg Uncertain significance Single submitter
- OGN p.Leu124Pro Uncertain significance Single submitter
- OGN p.Leu169Ser Uncertain significance Single submitter
- OGN p.Leu182Phe Uncertain significance Single submitter
- OGN p.Lys137Glu Uncertain significance Single submitter
- OGN p.Pro118Ala Uncertain significance Single submitter
- OGN p.Pro183Ser Uncertain significance Single submitter
- OGN p.Pro229Leu Uncertain significance Single submitter
- OGN p.Pro81Leu Uncertain significance Single submitter
- OGN p.Ser27Thr Uncertain significance Single submitter
- OGN p.Val278Phe Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All OGN variants
Likely benign 1
- p.Ile79Val Single submitter
Uncertain significance 31
- p.Ala122Thr Single submitter ⚠
- p.Ala126Thr Single submitter ⚠
- p.Ala78Val Single submitter ⚠
- p.Arg127Gly Single submitter ⚠
- p.Arg202Lys Single submitter ⚠
- p.Arg237Cys Single submitter ⚠
- p.Arg264Trp Single submitter ⚠
- p.Arg28His Single submitter ⚠
- p.Asn67Lys Single submitter ⚠
- p.Asn67Ser Single submitter ⚠
- p.Asp149Asn Single submitter ⚠
- p.Asp157Glu Single submitter ⚠
- p.Asp160Gly Single submitter ⚠
- p.Asp252Asn Single submitter ⚠
- p.Asp32Gly Single submitter ⚠
- p.Asp89Val Single submitter ⚠
- p.Gly161Ser Single submitter ⚠
- p.His222Arg Single submitter ⚠
- p.Leu124Pro Single submitter ⚠
- p.Leu169Ser Single submitter ⚠
- p.Leu182Phe Single submitter ⚠
- p.Lys133Gln Single submitter ⚠
- p.Lys137Glu Single submitter ⚠
- p.Phe254Leu Single submitter ⚠
- p.Pro118Ala Single submitter ⚠
- p.Pro183Ser Single submitter ⚠
- p.Pro229Leu Single submitter ⚠
- p.Pro276Ser Single submitter ⚠
- p.Pro81Leu Single submitter ⚠
- p.Ser27Thr Single submitter ⚠
- p.Val278Phe Single submitter ⚠