OLA1 — 47 ClinVar variants
All ClinVar germline OLA1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
47 Uncertain significance
Full OLA1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 35
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- OLA1 p.Ala100Val Uncertain significance Single submitter
- OLA1 p.Ala116Thr Uncertain significance Single submitter
- OLA1 p.Ala285Glu Uncertain significance Single submitter
- OLA1 p.Ala364Thr Uncertain significance Single submitter
- OLA1 p.Arg279Lys Uncertain significance Single submitter
- OLA1 p.Arg317His Uncertain significance Single submitter
- OLA1 p.Asp140His Uncertain significance Single submitter
- OLA1 p.Glu273Asp Uncertain significance Single submitter
- OLA1 p.Glu284Asp Uncertain significance Single submitter
- OLA1 p.Gly161Glu Uncertain significance Single submitter
- OLA1 p.Ile185Val Uncertain significance Single submitter
- OLA1 p.Ile25Val Uncertain significance Single submitter
- OLA1 p.Ile27Val Uncertain significance Single submitter
- OLA1 p.Ile382Thr Uncertain significance Single submitter
- OLA1 p.Leu152Phe Uncertain significance Single submitter
- OLA1 p.Leu259Phe Uncertain significance Single submitter
- OLA1 p.Leu259Ser Uncertain significance Single submitter
- OLA1 p.Leu274Met Uncertain significance Single submitter
- OLA1 p.Lys367Met Uncertain significance Single submitter
- OLA1 p.Met186Leu Uncertain significance Single submitter
- OLA1 p.Met344Val Uncertain significance Single submitter
- OLA1 p.Phe300Tyr Uncertain significance Single submitter
- OLA1 p.Phe308Leu Uncertain significance Single submitter
- OLA1 p.Phe338Leu Uncertain significance Single submitter
- OLA1 p.Pro13Leu Uncertain significance Single submitter
- OLA1 p.Pro256Gln Uncertain significance Single submitter
- OLA1 p.Pro256Ser Uncertain significance Single submitter
- OLA1 p.Pro393Leu Uncertain significance Single submitter
- OLA1 p.Pro67Ser Uncertain significance Single submitter
- OLA1 p.Ser358Thr Uncertain significance Single submitter
- OLA1 p.Tyr203Cys Uncertain significance Single submitter
- OLA1 p.Tyr203Ser Uncertain significance Single submitter
- OLA1 p.Tyr254His Uncertain significance Single submitter
- OLA1 p.Val135Ile Uncertain significance Single submitter
- OLA1 p.Val193Leu Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- OLA1 p.Asn40Ser Uncertain significance Single submitter
- OLA1 p.Asp195Asn Uncertain significance Single submitter
- OLA1 p.Gln196Arg Uncertain significance Single submitter
- OLA1 p.Gln289Arg Uncertain significance Single submitter
- OLA1 p.His122Gln Uncertain significance Single submitter
- OLA1 p.Leu274Ser Uncertain significance Single submitter
- OLA1 p.Ser45Asn Uncertain significance Single submitter
- OLA1 p.Ser45Gly Uncertain significance Single submitter
-
OLA1 p.Phe263Val
Uncertain significance
No assertion criteria
prostate cancer
All OLA1 variants
Uncertain significance 47
- p.Ala100Val Single submitter ⚠
- p.Ala116Thr Single submitter ⚠
- p.Ala285Glu Single submitter ⚠
- p.Ala364Thr Single submitter ⚠
- p.Arg279Lys Single submitter ⚠
- p.Arg317His Single submitter ⚠
- p.Asn40Ser Single submitter ⚠
- p.Asp140His Single submitter ⚠
- p.Asp195Asn Single submitter ⚠
- p.Gln196Arg Single submitter ⚠
- p.Gln289Arg Single submitter ⚠
- p.Glu273Asp Single submitter ⚠
- p.Glu284Asp Single submitter ⚠
- p.Gly161Glu Single submitter ⚠
- p.His101Tyr Single submitter
- p.His122Gln Single submitter ⚠
- p.Ile145Thr Single submitter
- p.Ile185Val Single submitter ⚠
- p.Ile25Thr Single submitter
- p.Ile25Val Single submitter ⚠
- p.Ile27Val Single submitter ⚠
- p.Ile382Thr Single submitter ⚠
- p.Leu152Phe Single submitter ⚠
- p.Leu259Phe Single submitter ⚠
- p.Leu259Ser Single submitter ⚠
- p.Leu274Met Single submitter ⚠
- p.Leu274Ser Single submitter ⚠
- p.Lys367Met Single submitter ⚠
- p.Met186Leu Single submitter ⚠
- p.Met344Val Single submitter ⚠
- p.Phe300Tyr Single submitter ⚠
- p.Phe308Leu Single submitter ⚠
- p.Phe338Leu Single submitter ⚠
- p.Pro13Leu Single submitter ⚠
- p.Pro256Gln Single submitter ⚠
- p.Pro256Ser Single submitter ⚠
- p.Pro393Leu Single submitter ⚠
- p.Pro67Ser Single submitter ⚠
- p.Ser358Thr Single submitter ⚠
- p.Ser45Asn Single submitter ⚠
- p.Ser45Gly Single submitter ⚠
- p.Tyr203Cys Single submitter ⚠
- p.Tyr203Ser Single submitter ⚠
- p.Tyr254His Single submitter ⚠
- p.Val135Ile Single submitter ⚠
- p.Val193Leu Single submitter ⚠
- p.Phe263Val No assertion criteria prostate cancer ⚠