OPRD1 — 41 ClinVar variants
All ClinVar germline OPRD1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 40 flagged for review →
41 Uncertain significance
Full OPRD1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 40
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- OPRD1 p.Ala195Thr Uncertain significance Single submitter
- OPRD1 p.Ala26Ser Uncertain significance Single submitter
- OPRD1 p.Ala275Thr Uncertain significance Single submitter
- OPRD1 p.Ala370Ser Uncertain significance Single submitter
- OPRD1 p.Ala61Val Uncertain significance Single submitter
- OPRD1 p.Ala9Thr Uncertain significance Single submitter
- OPRD1 p.Arg192Gln Uncertain significance Single submitter
- OPRD1 p.Arg347His Uncertain significance Single submitter
- OPRD1 p.Arg354Ser Uncertain significance Single submitter
- OPRD1 p.Arg356His Uncertain significance Single submitter
- OPRD1 p.Arg41Trp Uncertain significance Single submitter
- OPRD1 p.Gln12Arg Uncertain significance Single submitter
- OPRD1 p.Glu118Lys Uncertain significance Single submitter
- OPRD1 p.Gly365Asp Uncertain significance Single submitter
- OPRD1 p.Gly367Ser Uncertain significance Single submitter
- OPRD1 p.Ile228Val Uncertain significance Single submitter
- OPRD1 p.Leu65Val Uncertain significance Single submitter
- OPRD1 p.Lys250Glu Uncertain significance Single submitter
- OPRD1 p.Lys252Arg Uncertain significance Single submitter
- OPRD1 p.Met132Ile Uncertain significance Single submitter
- OPRD1 p.Pro103Thr Uncertain significance Single submitter
- OPRD1 p.Pro14Leu Uncertain significance Single submitter
- OPRD1 p.Pro24Ala Uncertain significance Single submitter
- OPRD1 p.Pro24Leu Uncertain significance Single submitter
- OPRD1 p.Pro5Ser Uncertain significance Single submitter
- OPRD1 p.Ser44Leu Uncertain significance Single submitter
- OPRD1 p.Ser45Thr Uncertain significance Single submitter
- OPRD1 p.Ser6Ala Uncertain significance Single submitter
- OPRD1 p.Thr138Met Uncertain significance Single submitter
- OPRD1 p.Thr361Asn Uncertain significance Single submitter
- OPRD1 p.Thr361Ile Uncertain significance Single submitter
- OPRD1 p.Tyr233Cys Uncertain significance Single submitter
- OPRD1 p.Val271Leu Uncertain significance Single submitter
- OPRD1 p.Val68Leu Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- OPRD1 p.Arg160Cys Uncertain significance Single submitter
- OPRD1 p.Arg190Cys Uncertain significance Single submitter
- OPRD1 p.Leu246Pro Uncertain significance Single submitter
- OPRD1 p.Met186Lys Uncertain significance Single submitter
- OPRD1 p.Ser20Trp Uncertain significance Single submitter
- OPRD1 p.Thr113Met Uncertain significance Single submitter
All OPRD1 variants
Uncertain significance 41
- p.Ala195Thr Single submitter ⚠
- p.Ala26Ser Single submitter ⚠
- p.Ala275Thr Single submitter ⚠
- p.Ala370Ser Single submitter ⚠
- p.Ala61Val Single submitter ⚠
- p.Ala9Thr Single submitter ⚠
- p.Arg160Cys Single submitter ⚠
- p.Arg190Cys Single submitter ⚠
- p.Arg192Gln Single submitter ⚠
- p.Arg347His Single submitter ⚠
- p.Arg354Ser Single submitter ⚠
- p.Arg356His Single submitter ⚠
- p.Arg41Trp Single submitter ⚠
- p.Asn90Ser Single submitter
- p.Gln12Arg Single submitter ⚠
- p.Glu118Lys Single submitter ⚠
- p.Gly365Asp Single submitter ⚠
- p.Gly367Ser Single submitter ⚠
- p.Ile228Val Single submitter ⚠
- p.Leu246Pro Single submitter ⚠
- p.Leu65Val Single submitter ⚠
- p.Lys250Glu Single submitter ⚠
- p.Lys252Arg Single submitter ⚠
- p.Met132Ile Single submitter ⚠
- p.Met186Lys Single submitter ⚠
- p.Pro103Thr Single submitter ⚠
- p.Pro14Leu Single submitter ⚠
- p.Pro24Ala Single submitter ⚠
- p.Pro24Leu Single submitter ⚠
- p.Pro5Ser Single submitter ⚠
- p.Ser20Trp Single submitter ⚠
- p.Ser44Leu Single submitter ⚠
- p.Ser45Thr Single submitter ⚠
- p.Ser6Ala Single submitter ⚠
- p.Thr113Met Single submitter ⚠
- p.Thr138Met Single submitter ⚠
- p.Thr361Asn Single submitter ⚠
- p.Thr361Ile Single submitter ⚠
- p.Tyr233Cys Single submitter ⚠
- p.Val271Leu Single submitter ⚠
- p.Val68Leu Single submitter ⚠