OPRK1 — 22 ClinVar variants
All ClinVar germline OPRK1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 20 flagged for review →
1 Benign · 1 Likely benign · 20 Uncertain significance
Full OPRK1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 20
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 13
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- OPRK1 p.Ala17Pro Uncertain significance Single submitter
- OPRK1 p.Arg170His Uncertain significance Single submitter
- OPRK1 p.Gln48His Uncertain significance Single submitter
- OPRK1 p.Gly13Asp Uncertain significance Single submitter
- OPRK1 p.Gly32Val Uncertain significance Single submitter
- OPRK1 p.Ile133Leu Uncertain significance Single submitter
- OPRK1 p.Pro12Leu Uncertain significance Single submitter
- OPRK1 p.Pro24Arg Uncertain significance Single submitter
- OPRK1 p.Pro51Ser Uncertain significance Single submitter
- OPRK1 p.Thr94Asn Uncertain significance Single submitter
- OPRK1 p.Tyr66Cys Uncertain significance Single submitter
- OPRK1 p.Tyr87Cys Uncertain significance Single submitter
- OPRK1 p.Val71Ala Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- OPRK1 p.Gly73Ala Uncertain significance Single submitter
- OPRK1 p.Ile137Thr Uncertain significance Single submitter
- OPRK1 p.Ile98Met Uncertain significance Single submitter
- OPRK1 p.Phe8Leu Uncertain significance Single submitter
- OPRK1 p.Phe99Leu Uncertain significance Single submitter
- OPRK1 p.Ser55Phe Uncertain significance Single submitter
- OPRK1 p.Thr148Ser Uncertain significance Single submitter
All OPRK1 variants
Benign 1
- p.Lys200Glu Single submitter
Likely benign 1
- p.Asn39= Single submitter
Uncertain significance 20
- p.Ala17Pro Single submitter ⚠
- p.Arg170His Single submitter ⚠
- p.Gln48His Single submitter ⚠
- p.Gly13Asp Single submitter ⚠
- p.Gly32Val Single submitter ⚠
- p.Gly73Ala Single submitter ⚠
- p.Ile133Leu Single submitter ⚠
- p.Ile137Thr Single submitter ⚠
- p.Ile98Met Single submitter ⚠
- p.Phe8Leu Single submitter ⚠
- p.Phe99Leu Single submitter ⚠
- p.Pro12Leu Single submitter ⚠
- p.Pro24Arg Single submitter ⚠
- p.Pro51Ser Single submitter ⚠
- p.Ser55Phe Single submitter ⚠
- p.Thr148Ser Single submitter ⚠
- p.Thr94Asn Single submitter ⚠
- p.Tyr66Cys Single submitter ⚠
- p.Tyr87Cys Single submitter ⚠
- p.Val71Ala Single submitter ⚠