OPRL1 — 54 ClinVar variants
All ClinVar germline OPRL1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 47 flagged for review →
3 Benign · 1 Likely benign · 50 Uncertain significance
Full OPRL1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 47
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 40
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- OPRL1 p.Ala176Pro Uncertain significance Single submitter
- OPRL1 p.Ala40Thr Uncertain significance Single submitter
- OPRL1 p.Arg240Gln Uncertain significance Single submitter
- OPRL1 p.Arg240Trp Uncertain significance Single submitter
- OPRL1 p.Arg241Trp Uncertain significance Single submitter
- OPRL1 p.Arg246His Uncertain significance Single submitter
- OPRL1 p.Arg331His Uncertain significance Single submitter
- OPRL1 p.Arg340Cys Uncertain significance Single submitter
- OPRL1 p.Arg341Trp Uncertain significance Single submitter
- OPRL1 p.Asn39Thr Uncertain significance Single submitter
- OPRL1 p.Cys335Arg Uncertain significance Single submitter
- OPRL1 p.Glu194Lys Uncertain significance Single submitter
- OPRL1 p.Glu199Lys Uncertain significance Single submitter
- OPRL1 p.Glu295Lys Uncertain significance Single submitter
- OPRL1 p.Gly15Ser Uncertain significance Single submitter
- OPRL1 p.Gly244Ala Uncertain significance Single submitter
- OPRL1 p.Gly244Arg Uncertain significance Single submitter
- OPRL1 p.His35Arg Uncertain significance Single submitter
- OPRL1 p.Ile204Met Uncertain significance Single submitter
- OPRL1 p.Ile219Leu Uncertain significance Single submitter
- OPRL1 p.Ile261Val Uncertain significance Single submitter
- OPRL1 p.Leu122Gln Uncertain significance Single submitter
- OPRL1 p.Leu31Val Uncertain significance Single submitter
- OPRL1 p.Phe135Leu Uncertain significance Single submitter
- OPRL1 p.Pro117Leu Uncertain significance Single submitter
- OPRL1 p.Pro213Arg Uncertain significance Single submitter
- OPRL1 p.Pro292Leu Uncertain significance Single submitter
- OPRL1 p.Pro34Leu Uncertain significance Single submitter
- OPRL1 p.Pro3Leu Uncertain significance Single submitter
- OPRL1 p.Pro8Leu Uncertain significance Single submitter
- OPRL1 p.Ser346Thr Uncertain significance Single submitter
- OPRL1 p.Ser41Thr Uncertain significance Single submitter
- OPRL1 p.Thr109Met Uncertain significance Single submitter
- OPRL1 p.Trp175Arg Uncertain significance Single submitter
- OPRL1 p.Val170Ile Uncertain significance Single submitter
- OPRL1 p.Val193Gly Uncertain significance Single submitter
- OPRL1 p.Val268Ile Uncertain significance Single submitter
- OPRL1 p.Val283Met Uncertain significance Single submitter
- OPRL1 p.Val356Met Uncertain significance Single submitter
- OPRL1 p.Val55Met Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- OPRL1 p.Arg157Gly Uncertain significance Single submitter
- OPRL1 p.Gly64Arg Uncertain significance Single submitter
- OPRL1 p.Leu50His Uncertain significance Single submitter
- OPRL1 p.Met188Val Uncertain significance Single submitter
- OPRL1 p.Phe303Leu Uncertain significance Single submitter
- OPRL1 p.Ser23Phe Uncertain significance Single submitter
- OPRL1 p.Thr103Met Uncertain significance Single submitter
All OPRL1 variants
Likely benign 1
- p.Gly43Ser Single submitter
Uncertain significance 50
- p.Ala176Pro Single submitter ⚠
- p.Ala40Thr Single submitter ⚠
- p.Arg157Gly Single submitter ⚠
- p.Arg240Gln Single submitter ⚠
- p.Arg240Trp Single submitter ⚠
- p.Arg241Trp Single submitter ⚠
- p.Arg246His Single submitter ⚠
- p.Arg256Trp Single submitter
- p.Arg260His Single submitter
- p.Arg331His Single submitter ⚠
- p.Arg340Cys Single submitter ⚠
- p.Arg341Trp Single submitter ⚠
- p.Asn39Thr Single submitter ⚠
- p.Cys335Arg Single submitter ⚠
- p.Glu194Lys Single submitter ⚠
- p.Glu199Lys Single submitter ⚠
- p.Glu253Lys Single submitter
- p.Glu295Lys Single submitter ⚠
- p.Gly15Ser Single submitter ⚠
- p.Gly244Ala Single submitter ⚠
- p.Gly244Arg Single submitter ⚠
- p.Gly64Arg Single submitter ⚠
- p.His35Arg Single submitter ⚠
- p.Ile204Met Single submitter ⚠
- p.Ile219Leu Single submitter ⚠
- p.Ile261Val Single submitter ⚠
- p.Leu122Gln Single submitter ⚠
- p.Leu31Val Single submitter ⚠
- p.Leu50His Single submitter ⚠
- p.Met188Val Single submitter ⚠
- p.Phe135Leu Single submitter ⚠
- p.Phe303Leu Single submitter ⚠
- p.Pro117Leu Single submitter ⚠
- p.Pro213Arg Single submitter ⚠
- p.Pro292Leu Single submitter ⚠
- p.Pro34Leu Single submitter ⚠
- p.Pro3Leu Single submitter ⚠
- p.Pro8Leu Single submitter ⚠
- p.Ser23Phe Single submitter ⚠
- p.Ser346Thr Single submitter ⚠
- p.Ser41Thr Single submitter ⚠
- p.Thr103Met Single submitter ⚠
- p.Thr109Met Single submitter ⚠
- p.Trp175Arg Single submitter ⚠
- p.Val170Ile Single submitter ⚠
- p.Val193Gly Single submitter ⚠
- p.Val268Ile Single submitter ⚠
- p.Val283Met Single submitter ⚠
- p.Val356Met Single submitter ⚠
- p.Val55Met Single submitter ⚠