OPRM1 — 66 ClinVar variants
All ClinVar germline OPRM1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 51 flagged for review →
4 Benign · 9 Likely benign · 53 Uncertain significance
Full OPRM1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 51
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 38
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- OPRM1 p.Ala104Asp Uncertain significance Single submitter
- OPRM1 p.Ala10Thr Uncertain significance Single submitter
- OPRM1 p.Ala186Asp Uncertain significance Single submitter
- OPRM1 p.Arg184Gln Uncertain significance Single submitter
- OPRM1 p.Arg260Cys Uncertain significance Single submitter
- OPRM1 p.Arg275Lys Uncertain significance Single submitter
- OPRM1 p.Arg347Gln Uncertain significance Single submitter
- OPRM1 p.Arg373Lys Uncertain significance Single submitter
- OPRM1 p.Asn330Tyr Uncertain significance Single submitter
- OPRM1 p.Asn371Ser Uncertain significance Single submitter
- OPRM1 p.Asn9Lys Uncertain significance Single submitter
- OPRM1 p.Asp38Tyr Uncertain significance Single submitter
- OPRM1 p.Asp43Asn Uncertain significance Single submitter
- OPRM1 p.Cys172Tyr Uncertain significance Single submitter
- OPRM1 p.Glu343Asp Uncertain significance Single submitter
- OPRM1 p.Gly255Glu Uncertain significance Single submitter
- OPRM1 p.Gly54Arg Uncertain significance Single submitter
- OPRM1 p.His173Gln Uncertain significance Single submitter
- OPRM1 p.Ile144Leu Uncertain significance Single submitter
- OPRM1 p.Ile144Thr Uncertain significance Single submitter
- OPRM1 p.Ile324Val Uncertain significance Single submitter
- OPRM1 p.Ile360Thr Uncertain significance Single submitter
- OPRM1 p.Leu277Pro Uncertain significance Single submitter
- OPRM1 p.Leu58Pro Uncertain significance Single submitter
- OPRM1 p.Met266Val Uncertain significance Single submitter
- OPRM1 p.Met67Val Uncertain significance Single submitter
- OPRM1 p.Pro174Ala Uncertain significance Single submitter
- OPRM1 p.Pro174Ser Uncertain significance Single submitter
- OPRM1 p.Pro376Ser Uncertain significance Single submitter
- OPRM1 p.Ser23Pro Uncertain significance Single submitter
- OPRM1 p.Ser331Arg Uncertain significance Single submitter
- OPRM1 p.Ser365Pro Uncertain significance Single submitter
- OPRM1 p.Thr14Ala Uncertain significance Single submitter
- OPRM1 p.Thr372Ile Uncertain significance Single submitter
- OPRM1 p.Thr381Ile Uncertain significance Single submitter
- OPRM1 p.Thr381Pro Uncertain significance Single submitter
- OPRM1 p.Tyr212His Uncertain significance Single submitter
- OPRM1 p.Val165Asp Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- OPRM1 p.Cys348Arg Uncertain significance Multiple submitters
- OPRM1 p.Arg265His Uncertain significance Single submitter
- OPRM1 p.Arg275Gly Uncertain significance Single submitter
- OPRM1 p.Gly215Val Uncertain significance Single submitter
- OPRM1 p.Gly327Cys Uncertain significance Single submitter
- OPRM1 p.Ile240Thr Uncertain significance Single submitter
- OPRM1 p.Ile250Thr Uncertain significance Single submitter
- OPRM1 p.Leu333Phe Uncertain significance Single submitter
- OPRM1 p.Met132Thr Uncertain significance Single submitter
- OPRM1 p.Phe125Leu Uncertain significance Single submitter
- OPRM1 p.Pro355Thr Uncertain significance Single submitter
- OPRM1 p.Ser319Tyr Uncertain significance Single submitter
- OPRM1 p.Val252Met Uncertain significance Single submitter
All OPRM1 variants
Benign 4
- c.1164+74814C>T Single submitter
- c.1165-11152C>T Single submitter
- p.Ser147Cys Single submitter
- p.Thr314= Single submitter
Likely benign 9
- c.1165-10894G>A Single submitter
- c.-25C>T Single submitter
- p.Ala18Thr Single submitter
- p.Ala5Thr Single submitter
- p.Cys192Phe Single submitter
- p.Gly63_Ser64insGly Single submitter
- p.Pro47= Single submitter
- p.Pro7= Single submitter
- p.Thr14Ser Single submitter
Uncertain significance 53
- p.Cys348Arg Multiple submitters ⚠
- p.Ala104Asp Single submitter ⚠
- p.Ala10Thr Single submitter ⚠
- p.Ala186Asp Single submitter ⚠
- p.Arg184Gln Single submitter ⚠
- p.Arg260Cys Single submitter ⚠
- p.Arg265His Single submitter ⚠
- p.Arg275Gly Single submitter ⚠
- p.Arg275Lys Single submitter ⚠
- p.Arg347Gln Single submitter ⚠
- p.Arg350Gly Single submitter
- p.Arg373Lys Single submitter ⚠
- p.Asn330Tyr Single submitter ⚠
- p.Asn371Ser Single submitter ⚠
- p.Asn9Lys Single submitter ⚠
- p.Asp38Tyr Single submitter ⚠
- p.Asp43Asn Single submitter ⚠
- p.Cys172Tyr Single submitter ⚠
- p.Glu343Asp Single submitter ⚠
- p.Gly215Val Single submitter ⚠
- p.Gly255Glu Single submitter ⚠
- p.Gly327Cys Single submitter ⚠
- p.Gly54Arg Single submitter ⚠
- p.His173Gln Single submitter ⚠
- p.Ile144Leu Single submitter ⚠
- p.Ile144Thr Single submitter ⚠
- p.Ile240Thr Single submitter ⚠
- p.Ile250Thr Single submitter ⚠
- p.Ile324Val Single submitter ⚠
- p.Ile360Thr Single submitter ⚠
- p.Leu277Pro Single submitter ⚠
- p.Leu333Phe Single submitter ⚠
- p.Leu58Pro Single submitter ⚠
- p.Met132Thr Single submitter ⚠
- p.Met266Val Single submitter ⚠
- p.Met67Val Single submitter ⚠
- p.Phe125Leu Single submitter ⚠
- p.Pro174Ala Single submitter ⚠
- p.Pro174Ser Single submitter ⚠
- p.Pro355Thr Single submitter ⚠
- p.Pro376Ser Single submitter ⚠
- p.Ser23Pro Single submitter ⚠
- p.Ser319Tyr Single submitter ⚠
- p.Ser331Arg Single submitter ⚠
- p.Ser365Pro Single submitter ⚠
- p.Thr134Arg Single submitter
- p.Thr14Ala Single submitter ⚠
- p.Thr372Ile Single submitter ⚠
- p.Thr381Ile Single submitter ⚠
- p.Thr381Pro Single submitter ⚠
- p.Tyr212His Single submitter ⚠
- p.Val165Asp Single submitter ⚠
- p.Val252Met Single submitter ⚠