OR2A4 — 24 ClinVar variants
All ClinVar germline OR2A4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 23 flagged for review →
1 Likely benign · 23 Uncertain significance
Full OR2A4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 23
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 15
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- OR2A4 p.Ala73Pro Uncertain significance Single submitter
- OR2A4 p.Ala94Val Uncertain significance Single submitter
- OR2A4 p.Glu195Lys Uncertain significance Single submitter
- OR2A4 p.Glu268Gly Uncertain significance Single submitter
- OR2A4 p.Ile8Met Uncertain significance Single submitter
- OR2A4 p.Leu85Arg Uncertain significance Single submitter
- OR2A4 p.Lys185Glu Uncertain significance Single submitter
- OR2A4 p.Met257Thr Uncertain significance Single submitter
- OR2A4 p.Pro266Ser Uncertain significance Single submitter
- OR2A4 p.Ser278Asn Uncertain significance Single submitter
- OR2A4 p.Ser92Thr Uncertain significance Single submitter
- OR2A4 p.Thr6Ile Uncertain significance Single submitter
- OR2A4 p.Tyr217His Uncertain significance Single submitter
- OR2A4 p.Val18Ile Uncertain significance Single submitter
- OR2A4 p.Val250Phe Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- OR2A4 p.Asn194Lys Uncertain significance Single submitter
- OR2A4 p.His175Arg Uncertain significance Single submitter
- OR2A4 p.His55Tyr Uncertain significance Single submitter
- OR2A4 p.Ile173Met Uncertain significance Single submitter
- OR2A4 p.Leu29Pro Uncertain significance Single submitter
- OR2A4 p.Leu300Ser Uncertain significance Single submitter
- OR2A4 p.Lys235Asn Uncertain significance Single submitter
- OR2A4 p.Tyr34His Uncertain significance Single submitter
All OR2A4 variants
Likely benign 1
- p.Leu181Val Single submitter
Uncertain significance 23
- p.Ala73Pro Single submitter ⚠
- p.Ala94Val Single submitter ⚠
- p.Asn194Lys Single submitter ⚠
- p.Glu195Lys Single submitter ⚠
- p.Glu268Gly Single submitter ⚠
- p.His175Arg Single submitter ⚠
- p.His55Tyr Single submitter ⚠
- p.Ile173Met Single submitter ⚠
- p.Ile8Met Single submitter ⚠
- p.Leu29Pro Single submitter ⚠
- p.Leu300Ser Single submitter ⚠
- p.Leu85Arg Single submitter ⚠
- p.Lys185Glu Single submitter ⚠
- p.Lys235Asn Single submitter ⚠
- p.Met257Thr Single submitter ⚠
- p.Pro266Ser Single submitter ⚠
- p.Ser278Asn Single submitter ⚠
- p.Ser92Thr Single submitter ⚠
- p.Thr6Ile Single submitter ⚠
- p.Tyr217His Single submitter ⚠
- p.Tyr34His Single submitter ⚠
- p.Val18Ile Single submitter ⚠
- p.Val250Phe Single submitter ⚠