OR51E2 — 68 ClinVar variants
All ClinVar germline OR51E2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 65 flagged for review →
1 Likely benign · 67 Uncertain significance
Full OR51E2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 65
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 45
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- OR51E2 p.Ala304Val Uncertain significance Single submitter
- OR51E2 p.Ala71Gly Uncertain significance Single submitter
- OR51E2 p.Ala82Thr Uncertain significance Single submitter
- OR51E2 p.Ala95Gly Uncertain significance Single submitter
- OR51E2 p.Ala9Thr Uncertain significance Single submitter
- OR51E2 p.Arg301Gln Uncertain significance Single submitter
- OR51E2 p.Arg52His Uncertain significance Single submitter
- OR51E2 p.Arg89Gln Uncertain significance Single submitter
- OR51E2 p.Asn137Asp Uncertain significance Single submitter
- OR51E2 p.Asn171Ser Uncertain significance Single submitter
- OR51E2 p.Asn5Lys Uncertain significance Single submitter
- OR51E2 p.Asp313Asn Uncertain significance Single submitter
- OR51E2 p.Cys178Gly Uncertain significance Single submitter
- OR51E2 p.Cys310Ser Uncertain significance Single submitter
- OR51E2 p.Cys96Ser Uncertain significance Single submitter
- OR51E2 p.Gln226Lys Uncertain significance Single submitter
- OR51E2 p.Glu20Gln Uncertain significance Single submitter
- OR51E2 p.Glu90Lys Uncertain significance Single submitter
- OR51E2 p.Leu161Pro Uncertain significance Single submitter
- OR51E2 p.Leu65Pro Uncertain significance Single submitter
- OR51E2 p.Lys230Asn Uncertain significance Single submitter
- OR51E2 p.Lys320Glu Uncertain significance Single submitter
- OR51E2 p.Met100Val Uncertain significance Single submitter
- OR51E2 p.Met275Val Uncertain significance Single submitter
- OR51E2 p.Met33Val Uncertain significance Single submitter
- OR51E2 p.Met77Val Uncertain significance Single submitter
- OR51E2 p.Phe155Tyr Uncertain significance Single submitter
- OR51E2 p.Pro193Leu Uncertain significance Single submitter
- OR51E2 p.Ser152Cys Uncertain significance Single submitter
- OR51E2 p.Ser32Pro Uncertain significance Single submitter
- OR51E2 p.Thr10Asn Uncertain significance Single submitter
- OR51E2 p.Thr300Arg Uncertain significance Single submitter
- OR51E2 p.Thr300Ile Uncertain significance Single submitter
- OR51E2 p.Thr50Met Uncertain significance Single submitter
- OR51E2 p.Thr50Ser Uncertain significance Single submitter
- OR51E2 p.Tyr122His Uncertain significance Single submitter
- OR51E2 p.Tyr188Cys Uncertain significance Single submitter
- OR51E2 p.Tyr197Phe Uncertain significance Single submitter
- OR51E2 p.Tyr291Cys Uncertain significance Single submitter
- OR51E2 p.Val146Met Uncertain significance Single submitter
- OR51E2 p.Val210Ile Uncertain significance Single submitter
- OR51E2 p.Val260Ile Uncertain significance Single submitter
- OR51E2 p.Val271Ala Uncertain significance Single submitter
- OR51E2 p.Val44Met Uncertain significance Single submitter
- OR51E2 p.Val48Ile Uncertain significance Single submitter
Predictors split 20
The independent predictors disagree with each other — read with care.
- OR51E2 p.Ala236Asp Uncertain significance Single submitter
- OR51E2 p.Arg150His Uncertain significance Single submitter
- OR51E2 p.Arg233Gly Uncertain significance Single submitter
- OR51E2 p.Arg262His Uncertain significance Single submitter
- OR51E2 p.Arg272Cys Uncertain significance Single submitter
- OR51E2 p.Arg301Trp Uncertain significance Single submitter
- OR51E2 p.Asn171Asp Uncertain significance Single submitter
- OR51E2 p.Gln181Arg Uncertain significance Single submitter
- OR51E2 p.Gly207Arg Uncertain significance Single submitter
- OR51E2 p.His180Tyr Uncertain significance Single submitter
- OR51E2 p.His261Gln Uncertain significance Single submitter
- OR51E2 p.His268Tyr Uncertain significance Single submitter
- OR51E2 p.Ile162Thr Uncertain significance Single submitter
- OR51E2 p.Leu158Gln Uncertain significance Single submitter
- OR51E2 p.Leu215Ser Uncertain significance Single submitter
- OR51E2 p.Met58Leu Uncertain significance Single submitter
- OR51E2 p.Met58Thr Uncertain significance Single submitter
- OR51E2 p.Phe250Leu Uncertain significance Single submitter
- OR51E2 p.Ser92Ile Uncertain significance Single submitter
- OR51E2 p.Tyr34Cys Uncertain significance Single submitter
All OR51E2 variants
Likely benign 1
- p.Arg272His Single submitter
Uncertain significance 67
- p.Ala236Asp Single submitter ⚠
- p.Ala304Val Single submitter ⚠
- p.Ala71Gly Single submitter ⚠
- p.Ala82Thr Single submitter ⚠
- p.Ala95Gly Single submitter ⚠
- p.Ala9Thr Single submitter ⚠
- p.Arg150His Single submitter ⚠
- p.Arg233Gly Single submitter ⚠
- p.Arg262His Single submitter ⚠
- p.Arg272Cys Single submitter ⚠
- p.Arg301Gln Single submitter ⚠
- p.Arg301Trp Single submitter ⚠
- p.Arg52His Single submitter ⚠
- p.Arg89Gln Single submitter ⚠
- p.Asn137Asp Single submitter ⚠
- p.Asn171Asp Single submitter ⚠
- p.Asn171Ser Single submitter ⚠
- p.Asn287Ser Single submitter
- p.Asn5Lys Single submitter ⚠
- p.Asp313Asn Single submitter ⚠
- p.Cys178Gly Single submitter ⚠
- p.Cys310Ser Single submitter ⚠
- p.Cys96Ser Single submitter ⚠
- p.Gln181Arg Single submitter ⚠
- p.Gln226Lys Single submitter ⚠
- p.Glu20Gln Single submitter ⚠
- p.Glu90Lys Single submitter ⚠
- p.Gly207Arg Single submitter ⚠
- p.His180Tyr Single submitter ⚠
- p.His261Gln Single submitter ⚠
- p.His268Tyr Single submitter ⚠
- p.Ile162Thr Single submitter ⚠
- p.Leu114Val Single submitter
- p.Leu158Gln Single submitter ⚠
- p.Leu161Pro Single submitter ⚠
- p.Leu215Ser Single submitter ⚠
- p.Leu65Pro Single submitter ⚠
- p.Lys230Asn Single submitter ⚠
- p.Lys320Glu Single submitter ⚠
- p.Met100Val Single submitter ⚠
- p.Met275Val Single submitter ⚠
- p.Met33Val Single submitter ⚠
- p.Met58Leu Single submitter ⚠
- p.Met58Thr Single submitter ⚠
- p.Met77Val Single submitter ⚠
- p.Phe155Tyr Single submitter ⚠
- p.Phe250Leu Single submitter ⚠
- p.Pro193Leu Single submitter ⚠
- p.Ser152Cys Single submitter ⚠
- p.Ser32Pro Single submitter ⚠
- p.Ser92Ile Single submitter ⚠
- p.Thr10Asn Single submitter ⚠
- p.Thr300Arg Single submitter ⚠
- p.Thr300Ile Single submitter ⚠
- p.Thr50Met Single submitter ⚠
- p.Thr50Ser Single submitter ⚠
- p.Tyr122His Single submitter ⚠
- p.Tyr188Cys Single submitter ⚠
- p.Tyr197Phe Single submitter ⚠
- p.Tyr291Cys Single submitter ⚠
- p.Tyr34Cys Single submitter ⚠
- p.Val146Met Single submitter ⚠
- p.Val210Ile Single submitter ⚠
- p.Val260Ile Single submitter ⚠
- p.Val271Ala Single submitter ⚠
- p.Val44Met Single submitter ⚠
- p.Val48Ile Single submitter ⚠