ORAI3 — 40 ClinVar variants
All ClinVar germline ORAI3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 37 flagged for review →
2 Likely benign · 38 Uncertain significance
Full ORAI3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 37
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 29
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ORAI3 p.Ala225Gly Uncertain significance Single submitter
- ORAI3 p.Ala63Thr Uncertain significance Single submitter
- ORAI3 p.Arg145His Uncertain significance Single submitter
- ORAI3 p.Arg229Trp Uncertain significance Single submitter
- ORAI3 p.Arg58Trp Uncertain significance Single submitter
- ORAI3 p.Arg66Pro Uncertain significance Single submitter
- ORAI3 p.Asn209Lys Uncertain significance Single submitter
- ORAI3 p.Gln289His Uncertain significance Single submitter
- ORAI3 p.Gly158Val Uncertain significance Single submitter
- ORAI3 p.Gly239Arg Uncertain significance Single submitter
- ORAI3 p.Gly290Ala Uncertain significance Single submitter
- ORAI3 p.Gly290Val Uncertain significance Single submitter
- ORAI3 p.His32Arg Uncertain significance Single submitter
- ORAI3 p.Ile177Thr Uncertain significance Single submitter
- ORAI3 p.Leu113Phe Uncertain significance Single submitter
- ORAI3 p.Leu204Arg Uncertain significance Single submitter
- ORAI3 p.Leu204Phe Uncertain significance Single submitter
- ORAI3 p.Leu56Phe Uncertain significance Single submitter
- ORAI3 p.Lys279Glu Uncertain significance Single submitter
- ORAI3 p.Pro180Leu Uncertain significance Single submitter
- ORAI3 p.Pro184Ala Uncertain significance Single submitter
- ORAI3 p.Pro184Ser Uncertain significance Single submitter
- ORAI3 p.Pro211Leu Uncertain significance Single submitter
- ORAI3 p.Pro219Leu Uncertain significance Single submitter
- ORAI3 p.Ser138Leu Uncertain significance Single submitter
- ORAI3 p.Ser68Pro Uncertain significance Single submitter
- ORAI3 p.Thr185Ile Uncertain significance Single submitter
- ORAI3 p.Thr190Ile Uncertain significance Single submitter
- ORAI3 p.Thr67Lys Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- ORAI3 p.Cys226Tyr Uncertain significance Single submitter
- ORAI3 p.Leu38Pro Uncertain significance Single submitter
- ORAI3 p.Met39Thr Uncertain significance Single submitter
- ORAI3 p.Tyr35His Uncertain significance Single submitter
- ORAI3 p.Val104Met Uncertain significance Single submitter
- ORAI3 p.Val147Met Uncertain significance Single submitter
- ORAI3 p.Val255Met Uncertain significance Single submitter
- ORAI3 p.Val31Met Uncertain significance Single submitter
All ORAI3 variants
Likely benign 2
- p.Arg192Gln Single submitter
- p.Asp87Asn Single submitter
Uncertain significance 38
- p.Ala225Gly Single submitter ⚠
- p.Ala63Thr Single submitter ⚠
- p.Arg145His Single submitter ⚠
- p.Arg229Trp Single submitter ⚠
- p.Arg58Trp Single submitter ⚠
- p.Arg66Pro Single submitter ⚠
- p.Asn209Lys Single submitter ⚠
- p.Cys226Tyr Single submitter ⚠
- p.Gln289His Single submitter ⚠
- p.Gly158Val Single submitter ⚠
- p.Gly239Arg Single submitter ⚠
- p.Gly290Ala Single submitter ⚠
- p.Gly290Val Single submitter ⚠
- p.His144Gln Single submitter
- p.His32Arg Single submitter ⚠
- p.Ile177Thr Single submitter ⚠
- p.Leu113Phe Single submitter ⚠
- p.Leu204Arg Single submitter ⚠
- p.Leu204Phe Single submitter ⚠
- p.Leu38Pro Single submitter ⚠
- p.Leu56Phe Single submitter ⚠
- p.Lys279Glu Single submitter ⚠
- p.Met39Thr Single submitter ⚠
- p.Pro180Leu Single submitter ⚠
- p.Pro184Ala Single submitter ⚠
- p.Pro184Ser Single submitter ⚠
- p.Pro211Leu Single submitter ⚠
- p.Pro219Leu Single submitter ⚠
- p.Ser138Leu Single submitter ⚠
- p.Ser68Pro Single submitter ⚠
- p.Thr185Ile Single submitter ⚠
- p.Thr190Ile Single submitter ⚠
- p.Thr67Lys Single submitter ⚠
- p.Tyr35His Single submitter ⚠
- p.Val104Met Single submitter ⚠
- p.Val147Met Single submitter ⚠
- p.Val255Met Single submitter ⚠
- p.Val31Met Single submitter ⚠