Sugi Variant

Sugi Variant/ORC6

ORC6 — 173 ClinVar variants

All ClinVar germline ORC6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 59 flagged for review →

11 Pathogenic · 1 Pathogenic/Likely pathogenic · 5 Likely pathogenic · 7 Conflicting · 7 Benign · 2 Benign/Likely benign · 57 Likely benign · 83 Uncertain significance

Full ORC6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 59

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 2

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 46

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 10

The independent predictors disagree with each other — read with care.

All ORC6 variants

Pathogenic 11

Pathogenic/Likely pathogenic 1

Likely pathogenic 5

Conflicting classifications of pathogenicity 7

Benign 7

Benign/Likely benign 2

Likely benign 57

Uncertain significance 83