OSBPL3 — 118 ClinVar variants
All ClinVar germline OSBPL3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 107 flagged for review →
4 Likely benign · 114 Uncertain significance
Full OSBPL3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 107
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 86
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- OSBPL3 p.Ala254Thr Uncertain significance Single submitter
- OSBPL3 p.Ala350Val Uncertain significance Single submitter
- OSBPL3 p.Ala412Thr Uncertain significance Single submitter
- OSBPL3 p.Ala414Thr Uncertain significance Single submitter
- OSBPL3 p.Ala508Ser Uncertain significance Single submitter
- OSBPL3 p.Ala508Thr Uncertain significance Single submitter
- OSBPL3 p.Ala508Val Uncertain significance Single submitter
- OSBPL3 p.Ala592Val Uncertain significance Single submitter
- OSBPL3 p.Arg208Gln Uncertain significance Single submitter
- OSBPL3 p.Arg275Lys Uncertain significance Single submitter
- OSBPL3 p.Arg277Trp Uncertain significance Single submitter
- OSBPL3 p.Arg279Gly Uncertain significance Single submitter
- OSBPL3 p.Arg31Gln Uncertain significance Single submitter
- OSBPL3 p.Arg511Gln Uncertain significance Single submitter
- OSBPL3 p.Arg599Gln Uncertain significance Single submitter
- OSBPL3 p.Arg853Gln Uncertain significance Single submitter
- OSBPL3 p.Asn424His Uncertain significance Single submitter
- OSBPL3 p.Asn731Asp Uncertain significance Single submitter
- OSBPL3 p.Asp335Gly Uncertain significance Single submitter
- OSBPL3 p.Asp409Asn Uncertain significance Single submitter
- OSBPL3 p.Asp490Tyr Uncertain significance Single submitter
- OSBPL3 p.Asp492Gly Uncertain significance Single submitter
- OSBPL3 p.Asp859Asn Uncertain significance Single submitter
- OSBPL3 p.Cys98Ser Uncertain significance Single submitter
- OSBPL3 p.Glu334Gly Uncertain significance Single submitter
- OSBPL3 p.Glu396Ala Uncertain significance Single submitter
- OSBPL3 p.Glu756Asp Uncertain significance Single submitter
- OSBPL3 p.Gly102Arg Uncertain significance Single submitter
- OSBPL3 p.Gly260Ser Uncertain significance Single submitter
- OSBPL3 p.Gly417Val Uncertain significance Single submitter
- OSBPL3 p.Gly43Glu Uncertain significance Single submitter
- OSBPL3 p.Gly696Arg Uncertain significance Single submitter
- OSBPL3 p.Gly867Ser Uncertain significance Single submitter
- OSBPL3 p.His161Tyr Uncertain significance Single submitter
- OSBPL3 p.His230Arg Uncertain significance Single submitter
- OSBPL3 p.His755Asn Uncertain significance Single submitter
- OSBPL3 p.Ile281Thr Uncertain significance Single submitter
- OSBPL3 p.Ile281Val Uncertain significance Single submitter
- OSBPL3 p.Ile339Val Uncertain significance Single submitter
- OSBPL3 p.Ile827Val Uncertain significance Single submitter
- OSBPL3 p.Leu126Pro Uncertain significance Single submitter
- OSBPL3 p.Leu141Phe Uncertain significance Single submitter
- OSBPL3 p.Leu311Val Uncertain significance Single submitter
- OSBPL3 p.Leu41Val Uncertain significance Single submitter
- OSBPL3 p.Leu711Met Uncertain significance Single submitter
- OSBPL3 p.Leu835Val Uncertain significance Single submitter
- OSBPL3 p.Leu8Val Uncertain significance Single submitter
- OSBPL3 p.Lys109Arg Uncertain significance Single submitter
- OSBPL3 p.Lys415Gln Uncertain significance Single submitter
- OSBPL3 p.Lys55Glu Uncertain significance Single submitter
- OSBPL3 p.Met146Ile Uncertain significance Single submitter
- OSBPL3 p.Met146Leu Uncertain significance Single submitter
- OSBPL3 p.Met154Val Uncertain significance Single submitter
- OSBPL3 p.Met243Val Uncertain significance Single submitter
- OSBPL3 p.Met365Leu Uncertain significance Single submitter
- OSBPL3 p.Met662Val Uncertain significance Single submitter
- OSBPL3 p.Phe176Cys Uncertain significance Single submitter
- OSBPL3 p.Phe176Tyr Uncertain significance Single submitter
- OSBPL3 p.Pro266His Uncertain significance Single submitter
- OSBPL3 p.Pro373Leu Uncertain significance Single submitter
- OSBPL3 p.Pro500Ser Uncertain significance Single submitter
- OSBPL3 p.Pro521Arg Uncertain significance Single submitter
- OSBPL3 p.Pro521Leu Uncertain significance Single submitter
- OSBPL3 p.Pro607Leu Uncertain significance Single submitter
- OSBPL3 p.Ser11Thr Uncertain significance Single submitter
- OSBPL3 p.Ser139Leu Uncertain significance Single submitter
- OSBPL3 p.Ser173Cys Uncertain significance Single submitter
- OSBPL3 p.Ser272Leu Uncertain significance Single submitter
- OSBPL3 p.Ser30Gly Uncertain significance Single submitter
- OSBPL3 p.Ser323Cys Uncertain significance Single submitter
- OSBPL3 p.Ser374Pro Uncertain significance Single submitter
- OSBPL3 p.Ser510Ala Uncertain significance Single submitter
- OSBPL3 p.Ser729Thr Uncertain significance Single submitter
- OSBPL3 p.Thr21Ile Uncertain significance Single submitter
- OSBPL3 p.Thr612Ala Uncertain significance Single submitter
- OSBPL3 p.Thr687Ile Uncertain significance Single submitter
- OSBPL3 p.Trp653Arg Uncertain significance Single submitter
- OSBPL3 p.Tyr250His Uncertain significance Single submitter
- OSBPL3 p.Tyr75Cys Uncertain significance Single submitter
- OSBPL3 p.Val10Met Uncertain significance Single submitter
- OSBPL3 p.Val175Ala Uncertain significance Single submitter
- OSBPL3 p.Val234Ile Uncertain significance Single submitter
- OSBPL3 p.Val245Ile Uncertain significance Single submitter
- OSBPL3 p.Val377Leu Uncertain significance Single submitter
- OSBPL3 p.Val676Ile Uncertain significance Single submitter
- OSBPL3 p.Val676Phe Uncertain significance Single submitter
Predictors split 21
The independent predictors disagree with each other — read with care.
- OSBPL3 p.Arg274Gly Uncertain significance Single submitter
- OSBPL3 p.Arg42Ser Uncertain significance Single submitter
- OSBPL3 p.Arg617Gln Uncertain significance Single submitter
- OSBPL3 p.Arg841Trp Uncertain significance Single submitter
- OSBPL3 p.Cys114Trp Uncertain significance Single submitter
- OSBPL3 p.Glu682Gly Uncertain significance Single submitter
- OSBPL3 p.Glu791Lys Uncertain significance Single submitter
- OSBPL3 p.Gly621Ser Uncertain significance Single submitter
- OSBPL3 p.His632Tyr Uncertain significance Single submitter
- OSBPL3 p.Leu246Arg Uncertain significance Single submitter
- OSBPL3 p.Leu459Ser Uncertain significance Single submitter
- OSBPL3 p.Lys85Arg Uncertain significance Single submitter
- OSBPL3 p.Met332Ile Uncertain significance Single submitter
- OSBPL3 p.Met775Val Uncertain significance Single submitter
- OSBPL3 p.Phe622Leu Uncertain significance Single submitter
- OSBPL3 p.Phe722Leu Uncertain significance Single submitter
- OSBPL3 p.Phe73Ser Uncertain significance Single submitter
- OSBPL3 p.Pro675Ser Uncertain significance Single submitter
- OSBPL3 p.Ser242Arg Uncertain significance Single submitter
- OSBPL3 p.Ser642Ala Uncertain significance Single submitter
- OSBPL3 p.Val608Phe Uncertain significance Single submitter
All OSBPL3 variants
Likely benign 4
- p.His157Arg Single submitter
- p.Ile168Val Single submitter
- p.Val199Leu Single submitter
- p.Val53Ile Single submitter
Uncertain significance 114
- p.Ala254Thr Single submitter ⚠
- p.Ala350Val Single submitter ⚠
- p.Ala412Thr Single submitter ⚠
- p.Ala414Thr Single submitter ⚠
- p.Ala508Ser Single submitter ⚠
- p.Ala508Thr Single submitter ⚠
- p.Ala508Val Single submitter ⚠
- p.Ala592Val Single submitter ⚠
- p.Arg208Gln Single submitter ⚠
- p.Arg274Gly Single submitter ⚠
- p.Arg275Lys Single submitter ⚠
- p.Arg277Trp Single submitter ⚠
- p.Arg279Gly Single submitter ⚠
- p.Arg31Gln Single submitter ⚠
- p.Arg397Cys Single submitter
- p.Arg42Ser Single submitter ⚠
- p.Arg511Gln Single submitter ⚠
- p.Arg599Gln Single submitter ⚠
- p.Arg617Gln Single submitter ⚠
- p.Arg840Gln Single submitter
- p.Arg841Trp Single submitter ⚠
- p.Arg853Gln Single submitter ⚠
- p.Asn424His Single submitter ⚠
- p.Asn731Asp Single submitter ⚠
- p.Asp335Gly Single submitter ⚠
- p.Asp409Asn Single submitter ⚠
- p.Asp490Tyr Single submitter ⚠
- p.Asp492Gly Single submitter ⚠
- p.Asp859Asn Single submitter ⚠
- p.Cys114Trp Single submitter ⚠
- p.Cys98Ser Single submitter ⚠
- p.Glu334Gly Single submitter ⚠
- p.Glu396Ala Single submitter ⚠
- p.Glu682Gly Single submitter ⚠
- p.Glu756Asp Single submitter ⚠
- p.Glu791Lys Single submitter ⚠
- p.Gly102Arg Single submitter ⚠
- p.Gly260Ser Single submitter ⚠
- p.Gly417Val Single submitter ⚠
- p.Gly43Glu Single submitter ⚠
- p.Gly621Ser Single submitter ⚠
- p.Gly696Arg Single submitter ⚠
- p.Gly744Glu Single submitter
- p.Gly867Ser Single submitter ⚠
- p.His161Tyr Single submitter ⚠
- p.His230Arg Single submitter ⚠
- p.His632Tyr Single submitter ⚠
- p.His639Asn Single submitter
- p.His755Asn Single submitter ⚠
- p.Ile281Thr Single submitter ⚠
- p.Ile281Val Single submitter ⚠
- p.Ile339Val Single submitter ⚠
- p.Ile827Val Single submitter ⚠
- p.Leu126Pro Single submitter ⚠
- p.Leu141Phe Single submitter ⚠
- p.Leu246Arg Single submitter ⚠
- p.Leu311Val Single submitter ⚠
- p.Leu41Val Single submitter ⚠
- p.Leu459Ser Single submitter ⚠
- p.Leu711Met Single submitter ⚠
- p.Leu835Val Single submitter ⚠
- p.Leu8Val Single submitter ⚠
- p.Lys109Arg Single submitter ⚠
- p.Lys415Gln Single submitter ⚠
- p.Lys55Glu Single submitter ⚠
- p.Lys85Arg Single submitter ⚠
- p.Met146Ile Single submitter ⚠
- p.Met146Leu Single submitter ⚠
- p.Met154Val Single submitter ⚠
- p.Met243Val Single submitter ⚠
- p.Met332Ile Single submitter ⚠
- p.Met365Leu Single submitter ⚠
- p.Met662Val Single submitter ⚠
- p.Met775Val Single submitter ⚠
- p.Phe176Cys Single submitter ⚠
- p.Phe176Tyr Single submitter ⚠
- p.Phe622Leu Single submitter ⚠
- p.Phe722Leu Single submitter ⚠
- p.Phe73Ser Single submitter ⚠
- p.Pro266His Single submitter ⚠
- p.Pro292Leu Single submitter
- p.Pro373Leu Single submitter ⚠
- p.Pro500Ser Single submitter ⚠
- p.Pro521Arg Single submitter ⚠
- p.Pro521Leu Single submitter ⚠
- p.Pro607Leu Single submitter ⚠
- p.Pro675Ser Single submitter ⚠
- p.Ser11Thr Single submitter ⚠
- p.Ser139Leu Single submitter ⚠
- p.Ser173Cys Single submitter ⚠
- p.Ser242Arg Single submitter ⚠
- p.Ser272Leu Single submitter ⚠
- p.Ser30Gly Single submitter ⚠
- p.Ser323Cys Single submitter ⚠
- p.Ser374Pro Single submitter ⚠
- p.Ser510Ala Single submitter ⚠
- p.Ser630Gly Single submitter
- p.Ser642Ala Single submitter ⚠
- p.Ser729Thr Single submitter ⚠
- p.Thr21Ile Single submitter ⚠
- p.Thr612Ala Single submitter ⚠
- p.Thr687Ile Single submitter ⚠
- p.Trp653Arg Single submitter ⚠
- p.Tyr250His Single submitter ⚠
- p.Tyr75Cys Single submitter ⚠
- p.Val10Met Single submitter ⚠
- p.Val175Ala Single submitter ⚠
- p.Val234Ile Single submitter ⚠
- p.Val245Ile Single submitter ⚠
- p.Val377Leu Single submitter ⚠
- p.Val608Phe Single submitter ⚠
- p.Val629Ile Single submitter
- p.Val676Ile Single submitter ⚠
- p.Val676Phe Single submitter ⚠