OSBPL8 — 72 ClinVar variants
All ClinVar germline OSBPL8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 67 flagged for review →
3 Likely benign · 69 Uncertain significance
Full OSBPL8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 67
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 45
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- OSBPL8 p.Ala67Gly Uncertain significance Single submitter
- OSBPL8 p.Ala746Ser Uncertain significance Single submitter
- OSBPL8 p.Arg773His Uncertain significance Single submitter
- OSBPL8 p.Arg773Leu Uncertain significance Single submitter
- OSBPL8 p.Arg852Gln Uncertain significance Single submitter
- OSBPL8 p.Asn312Ser Uncertain significance Single submitter
- OSBPL8 p.Asn658Asp Uncertain significance Single submitter
- OSBPL8 p.Asp340Gly Uncertain significance Single submitter
- OSBPL8 p.Gln324Arg Uncertain significance Single submitter
- OSBPL8 p.Gln337Lys Uncertain significance Single submitter
- OSBPL8 p.Glu34Lys Uncertain significance Single submitter
- OSBPL8 p.Glu50Gln Uncertain significance Single submitter
- OSBPL8 p.His854Asn Uncertain significance Single submitter
- OSBPL8 p.Ile518Val Uncertain significance Single submitter
- OSBPL8 p.Ile550Val Uncertain significance Single submitter
- OSBPL8 p.Ile669Val Uncertain significance Single submitter
- OSBPL8 p.Ile81Val Uncertain significance Single submitter
- OSBPL8 p.Ile834Val Uncertain significance Single submitter
- OSBPL8 p.Leu298Ile Uncertain significance Single submitter
- OSBPL8 p.Leu686Arg Uncertain significance Single submitter
- OSBPL8 p.Leu880Phe Uncertain significance Single submitter
- OSBPL8 p.Lys49Thr Uncertain significance Single submitter
- OSBPL8 p.Lys57Arg Uncertain significance Single submitter
- OSBPL8 p.Lys769Arg Uncertain significance Single submitter
- OSBPL8 p.Met887Leu Uncertain significance Single submitter
- OSBPL8 p.Met887Val Uncertain significance Single submitter
- OSBPL8 p.Phe309Leu Uncertain significance Single submitter
- OSBPL8 p.Pro368Arg Uncertain significance Single submitter
- OSBPL8 p.Pro368Leu Uncertain significance Single submitter
- OSBPL8 p.Pro661Leu Uncertain significance Single submitter
- OSBPL8 p.Pro69Leu Uncertain significance Single submitter
- OSBPL8 p.Pro786Leu Uncertain significance Single submitter
- OSBPL8 p.Pro786Thr Uncertain significance Single submitter
- OSBPL8 p.Pro860Ser Uncertain significance Single submitter
- OSBPL8 p.Ser241Asn Uncertain significance Single submitter
- OSBPL8 p.Ser93Leu Uncertain significance Single submitter
- OSBPL8 p.Thr380Ala Uncertain significance Single submitter
- OSBPL8 p.Thr54Ser Uncertain significance Single submitter
- OSBPL8 p.Trp727Ser Uncertain significance Single submitter
- OSBPL8 p.Tyr365His Uncertain significance Single submitter
- OSBPL8 p.Val123Ile Uncertain significance Single submitter
- OSBPL8 p.Val465Ala Uncertain significance Single submitter
- OSBPL8 p.Val567Ile Uncertain significance Single submitter
- OSBPL8 p.Val690Gly Uncertain significance Single submitter
- OSBPL8 p.Val815Ile Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- OSBPL8 p.Ala222Ser Uncertain significance Single submitter
- OSBPL8 p.Ala247Thr Uncertain significance Single submitter
- OSBPL8 p.Arg689Trp Uncertain significance Single submitter
- OSBPL8 p.Arg718Gly Uncertain significance Single submitter
- OSBPL8 p.Arg773Cys Uncertain significance Single submitter
- OSBPL8 p.Asn755His Uncertain significance Single submitter
- OSBPL8 p.Gln759His Uncertain significance Single submitter
- OSBPL8 p.Glu217Lys Uncertain significance Single submitter
- OSBPL8 p.Glu725Lys Uncertain significance Single submitter
- OSBPL8 p.Gly185Arg Uncertain significance Single submitter
- OSBPL8 p.His671Asn Uncertain significance Single submitter
- OSBPL8 p.Leu462Ser Uncertain significance Single submitter
- OSBPL8 p.Lys504Ile Uncertain significance Single submitter
- OSBPL8 p.Met583Val Uncertain significance Single submitter
- OSBPL8 p.Phe448Leu Uncertain significance Single submitter
- OSBPL8 p.Phe745Leu Uncertain significance Single submitter
- OSBPL8 p.Ser350Arg Uncertain significance Single submitter
- OSBPL8 p.Thr116Arg Uncertain significance Single submitter
- OSBPL8 p.Thr273Ala Uncertain significance Single submitter
- OSBPL8 p.Thr377Ile Uncertain significance Single submitter
- OSBPL8 p.Thr598Ser Uncertain significance Single submitter
- OSBPL8 p.Val708Ala Uncertain significance Single submitter
All OSBPL8 variants
Likely benign 3
- p.Asp288Glu Single submitter
- p.His60Tyr Single submitter
- p.Val285Ile Single submitter
Uncertain significance 69
- p.Ala222Ser Single submitter ⚠
- p.Ala247Thr Single submitter ⚠
- p.Ala67Gly Single submitter ⚠
- p.Ala746Ser Single submitter ⚠
- p.Arg689Trp Single submitter ⚠
- p.Arg718Gly Single submitter ⚠
- p.Arg720Gln Single submitter
- p.Arg773Cys Single submitter ⚠
- p.Arg773His Single submitter ⚠
- p.Arg773Leu Single submitter ⚠
- p.Arg852Gln Single submitter ⚠
- p.Asn312Ser Single submitter ⚠
- p.Asn658Asp Single submitter ⚠
- p.Asn755His Single submitter ⚠
- p.Asp340Gly Single submitter ⚠
- p.Gln324Arg Single submitter ⚠
- p.Gln337Lys Single submitter ⚠
- p.Gln759His Single submitter ⚠
- p.Glu217Lys Single submitter ⚠
- p.Glu34Lys Single submitter ⚠
- p.Glu50Gln Single submitter ⚠
- p.Glu725Lys Single submitter ⚠
- p.Gly185Arg Single submitter ⚠
- p.His671Asn Single submitter ⚠
- p.His854Asn Single submitter ⚠
- p.Ile518Val Single submitter ⚠
- p.Ile550Val Single submitter ⚠
- p.Ile669Val Single submitter ⚠
- p.Ile81Val Single submitter ⚠
- p.Ile834Val Single submitter ⚠
- p.Leu298Ile Single submitter ⚠
- p.Leu462Ser Single submitter ⚠
- p.Leu686Arg Single submitter ⚠
- p.Leu880Phe Single submitter ⚠
- p.Lys49Thr Single submitter ⚠
- p.Lys504Ile Single submitter ⚠
- p.Lys57Arg Single submitter ⚠
- p.Lys769Arg Single submitter ⚠
- p.Met583Val Single submitter ⚠
- p.Met887Leu Single submitter ⚠
- p.Met887Val Single submitter ⚠
- p.Phe309Leu Single submitter ⚠
- p.Phe448Leu Single submitter ⚠
- p.Phe745Leu Single submitter ⚠
- p.Pro368Arg Single submitter ⚠
- p.Pro368Leu Single submitter ⚠
- p.Pro661Leu Single submitter ⚠
- p.Pro69Leu Single submitter ⚠
- p.Pro786Leu Single submitter ⚠
- p.Pro786Thr Single submitter ⚠
- p.Pro860Ser Single submitter ⚠
- p.Ser241Asn Single submitter ⚠
- p.Ser350Arg Single submitter ⚠
- p.Ser93Leu Single submitter ⚠
- p.Thr116Arg Single submitter ⚠
- p.Thr273Ala Single submitter ⚠
- p.Thr377Ile Single submitter ⚠
- p.Thr380Ala Single submitter ⚠
- p.Thr54Ser Single submitter ⚠
- p.Thr598Ser Single submitter ⚠
- p.Trp727Ser Single submitter ⚠
- p.Tyr365His Single submitter ⚠
- p.Tyr444Cys Single submitter
- p.Val123Ile Single submitter ⚠
- p.Val465Ala Single submitter ⚠
- p.Val567Ile Single submitter ⚠
- p.Val690Gly Single submitter ⚠
- p.Val708Ala Single submitter ⚠
- p.Val815Ile Single submitter ⚠