OTUB1 — 28 ClinVar variants
All ClinVar germline OTUB1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 26 flagged for review →
1 Likely benign · 27 Uncertain significance
Full OTUB1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 26
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 15
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- OTUB1 p.Asp157Asn Uncertain significance Single submitter
- OTUB1 p.Asp17Asn Uncertain significance Single submitter
- OTUB1 p.Glu123Gly Uncertain significance Single submitter
- OTUB1 p.Glu12Ala Uncertain significance Single submitter
- OTUB1 p.Glu5Asp Uncertain significance Single submitter
- OTUB1 p.His247Pro Uncertain significance Single submitter
- OTUB1 p.Ile67Val Uncertain significance Single submitter
- OTUB1 p.Leu227Phe Uncertain significance Single submitter
- OTUB1 p.Leu259Phe Uncertain significance Single submitter
- OTUB1 p.Lys10Arg Uncertain significance Single submitter
- OTUB1 p.Lys188Arg Uncertain significance Single submitter
- OTUB1 p.Ser228Arg Uncertain significance Single submitter
- OTUB1 p.Ser80Leu Uncertain significance Single submitter
- OTUB1 p.Tyr26Cys Uncertain significance Single submitter
- OTUB1 p.Val117Ala Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- OTUB1 p.Ala25Val Uncertain significance Single submitter
- OTUB1 p.Ala2Val Uncertain significance Single submitter
- OTUB1 p.Arg113Trp Uncertain significance Single submitter
- OTUB1 p.Arg185His Uncertain significance Single submitter
- OTUB1 p.Asp124Ala Uncertain significance Single submitter
- OTUB1 p.Asp35Asn Uncertain significance Single submitter
- OTUB1 p.Glu186Lys Uncertain significance Single submitter
- OTUB1 p.Gly252Ala Uncertain significance Single submitter
- OTUB1 p.Leu101Val Uncertain significance Single submitter
- OTUB1 p.Tyr26Ser Uncertain significance Single submitter
- OTUB1 p.Val229Met Uncertain significance Single submitter
All OTUB1 variants
Likely benign 1
- p.Arg113= Single submitter
Uncertain significance 27
- p.Ala25Val Single submitter ⚠
- p.Ala2Val Single submitter ⚠
- p.Arg113Trp Single submitter ⚠
- p.Arg185Cys Single submitter
- p.Arg185His Single submitter ⚠
- p.Asp124Ala Single submitter ⚠
- p.Asp157Asn Single submitter ⚠
- p.Asp17Asn Single submitter ⚠
- p.Asp35Asn Single submitter ⚠
- p.Glu123Gly Single submitter ⚠
- p.Glu12Ala Single submitter ⚠
- p.Glu186Lys Single submitter ⚠
- p.Glu5Asp Single submitter ⚠
- p.Gly252Ala Single submitter ⚠
- p.His247Pro Single submitter ⚠
- p.Ile67Val Single submitter ⚠
- p.Leu101Val Single submitter ⚠
- p.Leu227Phe Single submitter ⚠
- p.Leu259Phe Single submitter ⚠
- p.Lys10Arg Single submitter ⚠
- p.Lys188Arg Single submitter ⚠
- p.Ser228Arg Single submitter ⚠
- p.Ser80Leu Single submitter ⚠
- p.Tyr26Cys Single submitter ⚠
- p.Tyr26Ser Single submitter ⚠
- p.Val117Ala Single submitter ⚠
- p.Val229Met Single submitter ⚠