OVCA2 — 64 ClinVar variants
All ClinVar germline OVCA2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 56 flagged for review →
5 Likely benign · 59 Uncertain significance
Full OVCA2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 56
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 46
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- OVCA2 p.Ala28Ser Uncertain significance Single submitter
- OVCA2 p.Ala57Pro Uncertain significance Single submitter
- OVCA2 p.Ala80Val Uncertain significance Single submitter
- OVCA2 p.Arg16Gln Uncertain significance Single submitter
- OVCA2 p.Arg58Lys Uncertain significance Single submitter
- OVCA2 p.Arg8Trp Uncertain significance Single submitter
- OVCA2 p.Arg93Lys Uncertain significance Single submitter
- OVCA2 p.Arg93Ser Uncertain significance Single submitter
- OVCA2 p.Asp60His Uncertain significance Single submitter
- OVCA2 p.Gln120Pro Uncertain significance Single submitter
- OVCA2 p.Glu186Lys Uncertain significance Single submitter
- OVCA2 p.Gly132Ser Uncertain significance Single submitter
- OVCA2 p.Gly155Asp Uncertain significance Single submitter
- OVCA2 p.Gly44Ala Uncertain significance Single submitter
- OVCA2 p.Gly53Ala Uncertain significance Single submitter
- OVCA2 p.Gly94Arg Uncertain significance Single submitter
- OVCA2 p.Gly94Asp Uncertain significance Single submitter
- OVCA2 p.Ile182Val Uncertain significance Single submitter
- OVCA2 p.Leu106Met Uncertain significance Single submitter
- OVCA2 p.Leu109Val Uncertain significance Single submitter
- OVCA2 p.Leu10Arg Uncertain significance Single submitter
- OVCA2 p.Leu115Phe Uncertain significance Single submitter
- OVCA2 p.Leu219Phe Uncertain significance Single submitter
- OVCA2 p.Leu42Phe Uncertain significance Single submitter
- OVCA2 p.Leu7Val Uncertain significance Single submitter
- OVCA2 p.Leu95Gln Uncertain significance Single submitter
- OVCA2 p.Phe112Leu Uncertain significance Single submitter
- OVCA2 p.Phe194Ser Uncertain significance Single submitter
- OVCA2 p.Phe22Ser Uncertain significance Single submitter
- OVCA2 p.Pro142Leu Uncertain significance Single submitter
- OVCA2 p.Pro166Thr Uncertain significance Single submitter
- OVCA2 p.Pro183Ser Uncertain significance Single submitter
- OVCA2 p.Pro195Ala Uncertain significance Single submitter
- OVCA2 p.Pro195Thr Uncertain significance Single submitter
- OVCA2 p.Pro54Ser Uncertain significance Single submitter
- OVCA2 p.Ser184Phe Uncertain significance Single submitter
- OVCA2 p.Ser187Asn Uncertain significance Single submitter
- OVCA2 p.Ser18Asn Uncertain significance Single submitter
- OVCA2 p.Ser59Leu Uncertain significance Single submitter
- OVCA2 p.Ser63Thr Uncertain significance Single submitter
- OVCA2 p.Thr201Pro Uncertain significance Single submitter
- OVCA2 p.Thr26Ser Uncertain significance Single submitter
- OVCA2 p.Val128Leu Uncertain significance Single submitter
- OVCA2 p.Val181Ile Uncertain significance Single submitter
- OVCA2 p.Val40Leu Uncertain significance Single submitter
- OVCA2 p.Val9Phe Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- OVCA2 p.Ala197Val Uncertain significance Single submitter
- OVCA2 p.Ala28Pro Uncertain significance Single submitter
- OVCA2 p.Arg154Trp Uncertain significance Single submitter
- OVCA2 p.Gly27Arg Uncertain significance Single submitter
- OVCA2 p.Leu109Pro Uncertain significance Single submitter
- OVCA2 p.Leu33Val Uncertain significance Single submitter
- OVCA2 p.Phe22Leu Uncertain significance Single submitter
- OVCA2 p.Pro170Leu Uncertain significance Single submitter
- OVCA2 p.Pro65Leu Uncertain significance Single submitter
- OVCA2 p.Ser187Thr Uncertain significance Single submitter
All OVCA2 variants
Likely benign 5
Uncertain significance 59
- p.Ala123Val Single submitter
- p.Ala197Val Single submitter ⚠
- p.Ala28Pro Single submitter ⚠
- p.Ala28Ser Single submitter ⚠
- p.Ala57Pro Single submitter ⚠
- p.Ala80Val Single submitter ⚠
- p.Arg154Trp Single submitter ⚠
- p.Arg16Gln Single submitter ⚠
- p.Arg58Lys Single submitter ⚠
- p.Arg8Trp Single submitter ⚠
- p.Arg93Lys Single submitter ⚠
- p.Arg93Ser Single submitter ⚠
- p.Asp60His Single submitter ⚠
- p.Gln120Pro Single submitter ⚠
- p.Glu186Lys Single submitter ⚠
- p.Gly132Ser Single submitter ⚠
- p.Gly155Asp Single submitter ⚠
- p.Gly205Ser Single submitter
- p.Gly27Arg Single submitter ⚠
- p.Gly44Ala Single submitter ⚠
- p.Gly53Ala Single submitter ⚠
- p.Gly94Arg Single submitter ⚠
- p.Gly94Asp Single submitter ⚠
- p.Ile182Val Single submitter ⚠
- p.Leu106Met Single submitter ⚠
- p.Leu109Pro Single submitter ⚠
- p.Leu109Val Single submitter ⚠
- p.Leu10Arg Single submitter ⚠
- p.Leu115Phe Single submitter ⚠
- p.Leu219Phe Single submitter ⚠
- p.Leu33Val Single submitter ⚠
- p.Leu42Phe Single submitter ⚠
- p.Leu7Val Single submitter ⚠
- p.Leu95Gln Single submitter ⚠
- p.Phe112Leu Single submitter ⚠
- p.Phe194Ser Single submitter ⚠
- p.Phe22Leu Single submitter ⚠
- p.Phe22Ser Single submitter ⚠
- p.Pro142Leu Single submitter ⚠
- p.Pro166Thr Single submitter ⚠
- p.Pro170Leu Single submitter ⚠
- p.Pro183Ser Single submitter ⚠
- p.Pro195Ala Single submitter ⚠
- p.Pro195Thr Single submitter ⚠
- p.Pro54Ser Single submitter ⚠
- p.Pro65Leu Single submitter ⚠
- p.Ser184Phe Single submitter ⚠
- p.Ser187Asn Single submitter ⚠
- p.Ser187Cys Single submitter
- p.Ser187Thr Single submitter ⚠
- p.Ser18Asn Single submitter ⚠
- p.Ser59Leu Single submitter ⚠
- p.Ser63Thr Single submitter ⚠
- p.Thr201Pro Single submitter ⚠
- p.Thr26Ser Single submitter ⚠
- p.Val128Leu Single submitter ⚠
- p.Val181Ile Single submitter ⚠
- p.Val40Leu Single submitter ⚠
- p.Val9Phe Single submitter ⚠