P2RX6 — 68 ClinVar variants
All ClinVar germline P2RX6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 60 flagged for review →
7 Likely benign · 61 Uncertain significance
Full P2RX6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 60
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 35
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- P2RX6 p.Ala382Thr Uncertain significance Single submitter
- P2RX6 p.Ala400Ser Uncertain significance Single submitter
- P2RX6 p.Ala40Thr Uncertain significance Single submitter
- P2RX6 p.Ala60Ser Uncertain significance Single submitter
- P2RX6 p.Ala8Gly Uncertain significance Single submitter
- P2RX6 p.Arg311Cys Uncertain significance Single submitter
- P2RX6 p.Arg34Ser Uncertain significance Single submitter
- P2RX6 p.Arg37Leu Uncertain significance Single submitter
- P2RX6 p.Arg405Trp Uncertain significance Single submitter
- P2RX6 p.Asn137Asp Uncertain significance Single submitter
- P2RX6 p.Glu146Lys Uncertain significance Single submitter
- P2RX6 p.Glu255Gln Uncertain significance Single submitter
- P2RX6 p.Glu365Lys Uncertain significance Single submitter
- P2RX6 p.Gly150Asp Uncertain significance Single submitter
- P2RX6 p.Gly261Asp Uncertain significance Single submitter
- P2RX6 p.Gly439Arg Uncertain significance Single submitter
- P2RX6 p.His152Tyr Uncertain significance Single submitter
- P2RX6 p.His154Arg Uncertain significance Single submitter
- P2RX6 p.His284Gln Uncertain significance Single submitter
- P2RX6 p.Leu23Met Uncertain significance Single submitter
- P2RX6 p.Leu324Phe Uncertain significance Single submitter
- P2RX6 p.Lys88Arg Uncertain significance Single submitter
- P2RX6 p.Phe47Ile Uncertain significance Single submitter
- P2RX6 p.Pro239His Uncertain significance Single submitter
- P2RX6 p.Pro380Leu Uncertain significance Single submitter
- P2RX6 p.Ser279Phe Uncertain significance Single submitter
- P2RX6 p.Thr17Met Uncertain significance Single submitter
- P2RX6 p.Thr27Met Uncertain significance Single submitter
- P2RX6 p.Thr300Ile Uncertain significance Single submitter
- P2RX6 p.Thr412Lys Uncertain significance Single submitter
- P2RX6 p.Thr412Met Uncertain significance Single submitter
- P2RX6 p.Val162Ala Uncertain significance Single submitter
- P2RX6 p.Val179Met Uncertain significance Single submitter
- P2RX6 p.Val350Met Uncertain significance Single submitter
- P2RX6 p.Val84Ile Uncertain significance Single submitter
Predictors split 25
The independent predictors disagree with each other — read with care.
- P2RX6 p.Tyr52Cys Uncertain significance Multiple submitters
- P2RX6 p.Ala98Asp Uncertain significance Single submitter
- P2RX6 p.Arg169Gly Uncertain significance Single submitter
- P2RX6 p.Arg242Cys Uncertain significance Single submitter
- P2RX6 p.Arg93Trp Uncertain significance Single submitter
- P2RX6 p.Asn108Lys Uncertain significance Single submitter
- P2RX6 p.Gln105Leu Uncertain significance Single submitter
- P2RX6 p.Gly307Arg Uncertain significance Single submitter
- P2RX6 p.Gly344Arg Uncertain significance Single submitter
- P2RX6 p.Ile243Thr Uncertain significance Single submitter
- P2RX6 p.Leu260Pro Uncertain significance Single submitter
- P2RX6 p.Leu334Arg Uncertain significance Single submitter
- P2RX6 p.Lys78Arg Uncertain significance Single submitter
- P2RX6 p.Phe100Leu Uncertain significance Single submitter
- P2RX6 p.Phe206Leu Uncertain significance Single submitter
- P2RX6 p.Pro131Leu Uncertain significance Single submitter
- P2RX6 p.Pro188Leu Uncertain significance Single submitter
- P2RX6 p.Pro306Leu Uncertain significance Single submitter
- P2RX6 p.Pro306Thr Uncertain significance Single submitter
- P2RX6 p.Ser286Tyr Uncertain significance Single submitter
- P2RX6 p.Val109Met Uncertain significance Single submitter
- P2RX6 p.Val240Met Uncertain significance Single submitter
- P2RX6 p.Val247Met Uncertain significance Single submitter
- P2RX6 p.Val325Ile Uncertain significance Single submitter
- P2RX6 p.Val54Gly Uncertain significance Single submitter
All P2RX6 variants
Likely benign 7
- p.Arg398Gln Single submitter
- p.Arg405Gln Single submitter
- p.Gln233His Single submitter
- p.Ile75Val Single submitter
- p.Lys249Glu Single submitter
- p.Phe73Ile Single submitter
- p.Val339Ile Single submitter
Uncertain significance 61
- p.Tyr52Cys Multiple submitters ⚠
- p.Ala382Thr Single submitter ⚠
- p.Ala400Ser Single submitter ⚠
- p.Ala40Thr Single submitter ⚠
- p.Ala60Ser Single submitter ⚠
- p.Ala8Gly Single submitter ⚠
- p.Ala98Asp Single submitter ⚠
- p.Arg169Gly Single submitter ⚠
- p.Arg242Cys Single submitter ⚠
- p.Arg311Cys Single submitter ⚠
- p.Arg34Ser Single submitter ⚠
- p.Arg37Leu Single submitter ⚠
- p.Arg405Trp Single submitter ⚠
- p.Arg93Trp Single submitter ⚠
- p.Asn108Lys Single submitter ⚠
- p.Asn137Asp Single submitter ⚠
- p.Gln105Leu Single submitter ⚠
- p.Gln65Arg Single submitter
- p.Glu146Lys Single submitter ⚠
- p.Glu255Gln Single submitter ⚠
- p.Glu365Lys Single submitter ⚠
- p.Gly150Asp Single submitter ⚠
- p.Gly261Asp Single submitter ⚠
- p.Gly307Arg Single submitter ⚠
- p.Gly344Arg Single submitter ⚠
- p.Gly439Arg Single submitter ⚠
- p.His152Tyr Single submitter ⚠
- p.His154Arg Single submitter ⚠
- p.His284Gln Single submitter ⚠
- p.Ile243Thr Single submitter ⚠
- p.Leu23Met Single submitter ⚠
- p.Leu260Pro Single submitter ⚠
- p.Leu324Phe Single submitter ⚠
- p.Leu334Arg Single submitter ⚠
- p.Lys78Arg Single submitter ⚠
- p.Lys88Arg Single submitter ⚠
- p.Phe100Leu Single submitter ⚠
- p.Phe206Leu Single submitter ⚠
- p.Phe47Ile Single submitter ⚠
- p.Pro131Leu Single submitter ⚠
- p.Pro188Leu Single submitter ⚠
- p.Pro239His Single submitter ⚠
- p.Pro306Leu Single submitter ⚠
- p.Pro306Thr Single submitter ⚠
- p.Pro380Leu Single submitter ⚠
- p.Ser279Phe Single submitter ⚠
- p.Ser286Tyr Single submitter ⚠
- p.Thr17Met Single submitter ⚠
- p.Thr27Met Single submitter ⚠
- p.Thr300Ile Single submitter ⚠
- p.Thr412Lys Single submitter ⚠
- p.Thr412Met Single submitter ⚠
- p.Val109Met Single submitter ⚠
- p.Val162Ala Single submitter ⚠
- p.Val179Met Single submitter ⚠
- p.Val240Met Single submitter ⚠
- p.Val247Met Single submitter ⚠
- p.Val325Ile Single submitter ⚠
- p.Val350Met Single submitter ⚠
- p.Val54Gly Single submitter ⚠
- p.Val84Ile Single submitter ⚠