P2RY13 — 27 ClinVar variants
All ClinVar germline P2RY13 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 22 flagged for review →
4 Likely benign · 23 Uncertain significance
Full P2RY13 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 22
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- P2RY13 p.Ala65Val Uncertain significance Single submitter
- P2RY13 p.Arg117Cys Uncertain significance Single submitter
- P2RY13 p.Arg240Thr Uncertain significance Single submitter
- P2RY13 p.Arg334Thr Uncertain significance Single submitter
- P2RY13 p.Asp246His Uncertain significance Single submitter
- P2RY13 p.Cys311Tyr Uncertain significance Single submitter
- P2RY13 p.Gln332His Uncertain significance Single submitter
- P2RY13 p.Gln44Arg Uncertain significance Single submitter
- P2RY13 p.Glu254Lys Uncertain significance Single submitter
- P2RY13 p.His280Gln Uncertain significance Single submitter
- P2RY13 p.Ile212Val Uncertain significance Single submitter
- P2RY13 p.Leu11Gln Uncertain significance Single submitter
- P2RY13 p.Leu14Phe Uncertain significance Single submitter
- P2RY13 p.Lys156Asn Uncertain significance Single submitter
- P2RY13 p.Lys252Asn Uncertain significance Single submitter
- P2RY13 p.Phe258Ser Uncertain significance Single submitter
- P2RY13 p.Ser120Leu Uncertain significance Single submitter
- P2RY13 p.Val229Glu Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All P2RY13 variants
Likely benign 4
- p.Ala113Asp Single submitter
- p.Ile165Thr Single submitter
- p.Leu86= Single submitter
- p.Pro188= Single submitter
Uncertain significance 23
- p.Ala65Val Single submitter ⚠
- p.Arg117Cys Single submitter ⚠
- p.Arg240Thr Single submitter ⚠
- p.Arg334Thr Single submitter ⚠
- p.Asn84His Single submitter
- p.Asp246His Single submitter ⚠
- p.Cys311Tyr Single submitter ⚠
- p.Gln332His Single submitter ⚠
- p.Gln44Arg Single submitter ⚠
- p.Glu254Lys Single submitter ⚠
- p.His280Gln Single submitter ⚠
- p.Ile212Val Single submitter ⚠
- p.Leu101Phe Single submitter ⚠
- p.Leu11Gln Single submitter ⚠
- p.Leu14Phe Single submitter ⚠
- p.Leu86Phe Single submitter ⚠
- p.Lys156Asn Single submitter ⚠
- p.Lys252Asn Single submitter ⚠
- p.Phe118Ser Single submitter ⚠
- p.Phe258Ser Single submitter ⚠
- p.Phe78Leu Single submitter ⚠
- p.Ser120Leu Single submitter ⚠
- p.Val229Glu Single submitter ⚠