P2RY14 — 56 ClinVar variants
All ClinVar germline P2RY14 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 49 flagged for review →
1 Benign · 5 Likely benign · 50 Uncertain significance
Full P2RY14 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 49
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 38
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- P2RY14 p.Ala193Ser Uncertain significance Single submitter
- P2RY14 p.Ala193Thr Uncertain significance Single submitter
- P2RY14 p.Arg181Trp Uncertain significance Single submitter
- P2RY14 p.Arg222Gln Uncertain significance Single submitter
- P2RY14 p.Arg327Lys Uncertain significance Single submitter
- P2RY14 p.Arg95Ser Uncertain significance Single submitter
- P2RY14 p.Asn40Ser Uncertain significance Single submitter
- P2RY14 p.Asp321His Uncertain significance Single submitter
- P2RY14 p.Asp67Glu Uncertain significance Single submitter
- P2RY14 p.Gln162His Uncertain significance Single submitter
- P2RY14 p.Glu178Asp Uncertain significance Single submitter
- P2RY14 p.Gly85Asp Uncertain significance Single submitter
- P2RY14 p.His250Arg Uncertain significance Single submitter
- P2RY14 p.Ile132Thr Uncertain significance Single submitter
- P2RY14 p.Ile144Thr Uncertain significance Single submitter
- P2RY14 p.Ile173Thr Uncertain significance Single submitter
- P2RY14 p.Ile37Ser Uncertain significance Single submitter
- P2RY14 p.Ile46Lys Uncertain significance Single submitter
- P2RY14 p.Leu127Phe Uncertain significance Single submitter
- P2RY14 p.Leu84Phe Uncertain significance Single submitter
- P2RY14 p.Lys211Asn Uncertain significance Single submitter
- P2RY14 p.Met105Ile Uncertain significance Single submitter
- P2RY14 p.Met147Thr Uncertain significance Single submitter
- P2RY14 p.Pro313Gln Uncertain significance Single submitter
- P2RY14 p.Ser130Ala Uncertain significance Single submitter
- P2RY14 p.Ser134Leu Uncertain significance Single submitter
- P2RY14 p.Ser136Gly Uncertain significance Single submitter
- P2RY14 p.Ser163Asn Uncertain significance Single submitter
- P2RY14 p.Ser4Pro Uncertain significance Single submitter
- P2RY14 p.Ser71Thr Uncertain significance Single submitter
- P2RY14 p.Thr280Ser Uncertain significance Single submitter
- P2RY14 p.Thr337Ala Uncertain significance Single submitter
- P2RY14 p.Thr7Pro Uncertain significance Single submitter
- P2RY14 p.Trp196Arg Uncertain significance Single submitter
- P2RY14 p.Tyr295Ser Uncertain significance Single submitter
- P2RY14 p.Val167Ala Uncertain significance Single submitter
- P2RY14 p.Val288Ile Uncertain significance Single submitter
- P2RY14 p.Val50Leu Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- P2RY14 p.Ala35Glu Uncertain significance Single submitter
- P2RY14 p.Glu262Lys Uncertain significance Single submitter
- P2RY14 p.Glu271Val Uncertain significance Single submitter
- P2RY14 p.Leu19Pro Uncertain significance Single submitter
- P2RY14 p.Leu39Val Uncertain significance Single submitter
- P2RY14 p.Lys125Glu Uncertain significance Single submitter
- P2RY14 p.Phe296Leu Uncertain significance Single submitter
- P2RY14 p.Pro301Leu Benign Single submitter
- P2RY14 p.Trp45Cys Uncertain significance Single submitter
- P2RY14 p.Val145Ala Uncertain significance Single submitter
- P2RY14 p.Val91Glu Uncertain significance Single submitter
All P2RY14 variants
Benign 1
- p.Pro301Leu Single submitter ⚠
Likely benign 5
- p.Ile58Val Single submitter
- p.Leu310= Single submitter
- p.Leu320Pro Single submitter
- p.Tyr102= Single submitter
- p.Val204Ile Single submitter
Uncertain significance 50
- p.Ala186Glu Single submitter
- p.Ala193Ser Single submitter ⚠
- p.Ala193Thr Single submitter ⚠
- p.Ala35Glu Single submitter ⚠
- p.Arg181Trp Single submitter ⚠
- p.Arg222Gln Single submitter ⚠
- p.Arg327Lys Single submitter ⚠
- p.Arg95Ser Single submitter ⚠
- p.Asn40Ser Single submitter ⚠
- p.Asp321His Single submitter ⚠
- p.Asp67Glu Single submitter ⚠
- p.Gln162His Single submitter ⚠
- p.Glu178Asp Single submitter ⚠
- p.Glu262Lys Single submitter ⚠
- p.Glu271Val Single submitter ⚠
- p.Gly85Asp Single submitter ⚠
- p.His250Arg Single submitter ⚠
- p.Ile132Thr Single submitter ⚠
- p.Ile144Thr Single submitter ⚠
- p.Ile173Thr Single submitter ⚠
- p.Ile37Ser Single submitter ⚠
- p.Ile46Lys Single submitter ⚠
- p.Leu127Phe Single submitter ⚠
- p.Leu19Pro Single submitter ⚠
- p.Leu39Val Single submitter ⚠
- p.Leu84Phe Single submitter ⚠
- p.Lys125Glu Single submitter ⚠
- p.Lys211Asn Single submitter ⚠
- p.Met105Ile Single submitter ⚠
- p.Met147Thr Single submitter ⚠
- p.Phe296Leu Single submitter ⚠
- p.Pro126Thr Single submitter
- p.Pro313Gln Single submitter ⚠
- p.Ser130Ala Single submitter ⚠
- p.Ser134Leu Single submitter ⚠
- p.Ser136Gly Single submitter ⚠
- p.Ser163Asn Single submitter ⚠
- p.Ser4Pro Single submitter ⚠
- p.Ser71Thr Single submitter ⚠
- p.Thr280Ser Single submitter ⚠
- p.Thr337Ala Single submitter ⚠
- p.Thr7Pro Single submitter ⚠
- p.Trp196Arg Single submitter ⚠
- p.Trp45Cys Single submitter ⚠
- p.Tyr295Ser Single submitter ⚠
- p.Val145Ala Single submitter ⚠
- p.Val167Ala Single submitter ⚠
- p.Val288Ile Single submitter ⚠
- p.Val50Leu Single submitter ⚠
- p.Val91Glu Single submitter ⚠