P2RY2 — 75 ClinVar variants
All ClinVar germline P2RY2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 68 flagged for review →
1 Benign · 5 Likely benign · 69 Uncertain significance
Full P2RY2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 68
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 57
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- P2RY2 p.Ala176Thr Uncertain significance Single submitter
- P2RY2 p.Ala252Thr Uncertain significance Single submitter
- P2RY2 p.Ala309Pro Uncertain significance Single submitter
- P2RY2 p.Ala80Thr Uncertain significance Single submitter
- P2RY2 p.Ala94Asp Uncertain significance Single submitter
- P2RY2 p.Ala94Val Uncertain significance Single submitter
- P2RY2 p.Arg148Ser Uncertain significance Single submitter
- P2RY2 p.Arg152Pro Uncertain significance Single submitter
- P2RY2 p.Arg223Gly Uncertain significance Single submitter
- P2RY2 p.Arg241Pro Uncertain significance Single submitter
- P2RY2 p.Arg265Cys Uncertain significance Single submitter
- P2RY2 p.Arg315His Uncertain significance Single submitter
- P2RY2 p.Arg318Gln Uncertain significance Single submitter
- P2RY2 p.Arg318Gly Uncertain significance Single submitter
- P2RY2 p.Arg333Cys Uncertain significance Single submitter
- P2RY2 p.Arg333Gly Uncertain significance Single submitter
- P2RY2 p.Arg339Cys Uncertain significance Single submitter
- P2RY2 p.Arg340Thr Uncertain significance Single submitter
- P2RY2 p.Arg361Trp Uncertain significance Single submitter
- P2RY2 p.Arg376Trp Uncertain significance Single submitter
- P2RY2 p.Asn13Ser Uncertain significance Single submitter
- P2RY2 p.Asn28Lys Uncertain significance Single submitter
- P2RY2 p.Asp342Asn Uncertain significance Single submitter
- P2RY2 p.Cys119Arg Uncertain significance Single submitter
- P2RY2 p.Gln311Lys Uncertain significance Single submitter
- P2RY2 p.Glu370Gly Uncertain significance Single submitter
- P2RY2 p.Gly145Ser Uncertain significance Single submitter
- P2RY2 p.Gly231Arg Uncertain significance Single submitter
- P2RY2 p.Gly368Ser Uncertain significance Single submitter
- P2RY2 p.His130Pro Uncertain significance Single submitter
- P2RY2 p.Ile57Val Uncertain significance Single submitter
- P2RY2 p.Leu133Pro Uncertain significance Single submitter
- P2RY2 p.Leu215Val Uncertain significance Single submitter
- P2RY2 p.Leu256Ile Uncertain significance Single submitter
- P2RY2 p.Leu256Val Uncertain significance Single submitter
- P2RY2 p.Leu259Pro Uncertain significance Single submitter
- P2RY2 p.Leu276Pro Uncertain significance Single submitter
- P2RY2 p.Leu5Val Uncertain significance Single submitter
- P2RY2 p.Lys373Asn Uncertain significance Single submitter
- P2RY2 p.Met346Val Uncertain significance Single submitter
- P2RY2 p.Pro100Ser Uncertain significance Single submitter
- P2RY2 p.Pro189Arg Uncertain significance Single submitter
- P2RY2 p.Pro293Leu Uncertain significance Single submitter
- P2RY2 p.Pro326Thr Uncertain significance Single submitter
- P2RY2 p.Pro328Ser Uncertain significance Single submitter
- P2RY2 p.Pro331Arg Uncertain significance Single submitter
- P2RY2 p.Pro366Ala Uncertain significance Single submitter
- P2RY2 p.Pro87Thr Uncertain significance Single submitter
- P2RY2 p.Ser273Trp Uncertain significance Single submitter
- P2RY2 p.Ser369Asn Uncertain significance Single submitter
- P2RY2 p.Thr365Ala Uncertain significance Single submitter
- P2RY2 p.Trp158Arg Uncertain significance Single submitter
- P2RY2 p.Tyr82His Uncertain significance Single submitter
- P2RY2 p.Val104Met Uncertain significance Single submitter
- P2RY2 p.Val153Leu Uncertain significance Single submitter
- P2RY2 p.Val172Ala Uncertain significance Single submitter
- P2RY2 p.Val314Ile Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- P2RY2 p.Ala287Val Uncertain significance Single submitter
- P2RY2 p.Arg143Cys Uncertain significance Single submitter
- P2RY2 p.Arg148Cys Uncertain significance Single submitter
- P2RY2 p.Asn285Thr Uncertain significance Single submitter
- P2RY2 p.His74Tyr Uncertain significance Single submitter
- P2RY2 p.Leu117Ile Uncertain significance Single submitter
- P2RY2 p.Phe271Cys Uncertain significance Single submitter
- P2RY2 p.Pro189Ser Uncertain significance Single submitter
- P2RY2 p.Tyr93His Uncertain significance Single submitter
- P2RY2 p.Val109Leu Uncertain significance Single submitter
- P2RY2 p.Val34Met Uncertain significance Single submitter
All P2RY2 variants
Benign 1
- p.Asp17= Single submitter
Likely benign 5
- p.Ala329Thr Single submitter
- p.Arg194His Single submitter
- p.Arg339His Single submitter
- p.Asp17Gly Single submitter
- p.Met346Thr Single submitter
Uncertain significance 69
- p.Ala176Thr Single submitter ⚠
- p.Ala252Thr Single submitter ⚠
- p.Ala287Val Single submitter ⚠
- p.Ala309Pro Single submitter ⚠
- p.Ala80Thr Single submitter ⚠
- p.Ala94Asp Single submitter ⚠
- p.Ala94Val Single submitter ⚠
- p.Arg137fs Single submitter
- p.Arg143Cys Single submitter ⚠
- p.Arg148Cys Single submitter ⚠
- p.Arg148Ser Single submitter ⚠
- p.Arg152Pro Single submitter ⚠
- p.Arg223Gly Single submitter ⚠
- p.Arg241Pro Single submitter ⚠
- p.Arg265Cys Single submitter ⚠
- p.Arg315His Single submitter ⚠
- p.Arg318Gln Single submitter ⚠
- p.Arg318Gly Single submitter ⚠
- p.Arg333Cys Single submitter ⚠
- p.Arg333Gly Single submitter ⚠
- p.Arg339Cys Single submitter ⚠
- p.Arg340Thr Single submitter ⚠
- p.Arg361Trp Single submitter ⚠
- p.Arg376Trp Single submitter ⚠
- p.Asn13Ser Single submitter ⚠
- p.Asn285Thr Single submitter ⚠
- p.Asn28Lys Single submitter ⚠
- p.Asp342Asn Single submitter ⚠
- p.Cys119Arg Single submitter ⚠
- p.Gln311Lys Single submitter ⚠
- p.Glu370Gly Single submitter ⚠
- p.Gly145Ser Single submitter ⚠
- p.Gly231Arg Single submitter ⚠
- p.Gly368Ser Single submitter ⚠
- p.His130Pro Single submitter ⚠
- p.His74Tyr Single submitter ⚠
- p.Ile57Val Single submitter ⚠
- p.Leu117Ile Single submitter ⚠
- p.Leu133Pro Single submitter ⚠
- p.Leu215Val Single submitter ⚠
- p.Leu256Ile Single submitter ⚠
- p.Leu256Val Single submitter ⚠
- p.Leu259Pro Single submitter ⚠
- p.Leu276Pro Single submitter ⚠
- p.Leu5Val Single submitter ⚠
- p.Lys373Asn Single submitter ⚠
- p.Met346Val Single submitter ⚠
- p.Phe271Cys Single submitter ⚠
- p.Pro100Ser Single submitter ⚠
- p.Pro189Arg Single submitter ⚠
- p.Pro189Ser Single submitter ⚠
- p.Pro293Leu Single submitter ⚠
- p.Pro326Thr Single submitter ⚠
- p.Pro328Ser Single submitter ⚠
- p.Pro331Arg Single submitter ⚠
- p.Pro366Ala Single submitter ⚠
- p.Pro87Thr Single submitter ⚠
- p.Ser273Trp Single submitter ⚠
- p.Ser369Asn Single submitter ⚠
- p.Thr365Ala Single submitter ⚠
- p.Trp158Arg Single submitter ⚠
- p.Tyr82His Single submitter ⚠
- p.Tyr93His Single submitter ⚠
- p.Val104Met Single submitter ⚠
- p.Val109Leu Single submitter ⚠
- p.Val153Leu Single submitter ⚠
- p.Val172Ala Single submitter ⚠
- p.Val314Ile Single submitter ⚠
- p.Val34Met Single submitter ⚠