P2RY4 — 56 ClinVar variants
All ClinVar germline P2RY4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 48 flagged for review →
2 Benign · 1 Likely benign · 53 Uncertain significance
Full P2RY4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 48
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 40
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- P2RY4 p.Ala203Val Uncertain significance Single submitter
- P2RY4 p.Ala349Val Uncertain significance Single submitter
- P2RY4 p.Ala43Val Uncertain significance Single submitter
- P2RY4 p.Arg112Cys Uncertain significance Single submitter
- P2RY4 p.Arg133His Uncertain significance Single submitter
- P2RY4 p.Arg225Ser Uncertain significance Single submitter
- P2RY4 p.Arg240His Uncertain significance Single submitter
- P2RY4 p.Arg245His Uncertain significance Single submitter
- P2RY4 p.Arg265His Uncertain significance Single submitter
- P2RY4 p.Arg265Leu Uncertain significance Single submitter
- P2RY4 p.Arg315His Uncertain significance Single submitter
- P2RY4 p.Arg329Cys Uncertain significance Single submitter
- P2RY4 p.Arg63His Uncertain significance Single submitter
- P2RY4 p.Arg65Gln Uncertain significance Single submitter
- P2RY4 p.Asn170Ser Uncertain significance Single submitter
- P2RY4 p.Asp195Asn Uncertain significance Single submitter
- P2RY4 p.Asp30Val Uncertain significance Single submitter
- P2RY4 p.Asp343Gly Uncertain significance Single submitter
- P2RY4 p.Asp354Tyr Uncertain significance Single submitter
- P2RY4 p.Cys219Trp Uncertain significance Single submitter
- P2RY4 p.Cys321Tyr Uncertain significance Single submitter
- P2RY4 p.Gln236Leu Uncertain significance Single submitter
- P2RY4 p.Gly165Ser Uncertain significance Single submitter
- P2RY4 p.Gly51Ser Uncertain significance Single submitter
- P2RY4 p.Leu124Phe Uncertain significance Single submitter
- P2RY4 p.Pro149Thr Uncertain significance Single submitter
- P2RY4 p.Pro293Ala Uncertain significance Single submitter
- P2RY4 p.Pro303Leu Uncertain significance Single submitter
- P2RY4 p.Ser237Leu Uncertain significance Single submitter
- P2RY4 p.Ser6Thr Uncertain significance Single submitter
- P2RY4 p.Thr266Ala Uncertain significance Single submitter
- P2RY4 p.Thr330Met Uncertain significance Single submitter
- P2RY4 p.Thr351Ser Uncertain significance Single submitter
- P2RY4 p.Thr82Ile Uncertain significance Single submitter
- P2RY4 p.Tyr42His Uncertain significance Single submitter
- P2RY4 p.Tyr42Ser Uncertain significance Single submitter
- P2RY4 p.Val111Asp Uncertain significance Single submitter
- P2RY4 p.Val163Ile Uncertain significance Single submitter
- P2RY4 p.Val211Met Uncertain significance Single submitter
- P2RY4 p.Val287Gly Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- P2RY4 p.Arg148Cys Uncertain significance Single submitter
- P2RY4 p.Arg150Cys Uncertain significance Single submitter
- P2RY4 p.Arg150His Uncertain significance Single submitter
- P2RY4 p.Arg242His Uncertain significance Single submitter
- P2RY4 p.Arg63Cys Uncertain significance Single submitter
- P2RY4 p.Val131Met Uncertain significance Single submitter
- P2RY4 p.Val163Leu Uncertain significance Single submitter
- P2RY4 p.Val250Ala Uncertain significance Single submitter
All P2RY4 variants
Benign 2
- p.Arg318His Multiple submitters
- p.Leu14Phe Multiple submitters
Likely benign 1
- p.Arg279Gln Single submitter
Uncertain significance 53
- p.Ala203Val Single submitter ⚠
- p.Ala349Val Single submitter ⚠
- p.Ala43Val Single submitter ⚠
- p.Arg112Cys Single submitter ⚠
- p.Arg133His Single submitter ⚠
- p.Arg148Cys Single submitter ⚠
- p.Arg150Cys Single submitter ⚠
- p.Arg150His Single submitter ⚠
- p.Arg225Ser Single submitter ⚠
- p.Arg240Cys Single submitter
- p.Arg240His Single submitter ⚠
- p.Arg242His Single submitter ⚠
- p.Arg245His Single submitter ⚠
- p.Arg265His Single submitter ⚠
- p.Arg265Leu Single submitter ⚠
- p.Arg315His Single submitter ⚠
- p.Arg329Cys Single submitter ⚠
- p.Arg63Cys Single submitter ⚠
- p.Arg63His Single submitter ⚠
- p.Arg65Gln Single submitter ⚠
- p.Asn170Ser Single submitter ⚠
- p.Asp195Asn Single submitter ⚠
- p.Asp30Val Single submitter ⚠
- p.Asp343Gly Single submitter ⚠
- p.Asp354Tyr Single submitter ⚠
- p.Cys128Ser Single submitter
- p.Cys219Trp Single submitter ⚠
- p.Cys321Tyr Single submitter ⚠
- p.Gln236Leu Single submitter ⚠
- p.Gly165Ser Single submitter ⚠
- p.Gly51Ser Single submitter ⚠
- p.His139Leu Single submitter
- p.Leu124Phe Single submitter ⚠
- p.Pro149Thr Single submitter ⚠
- p.Pro293Ala Single submitter ⚠
- p.Pro303Leu Single submitter ⚠
- p.Ser237Leu Single submitter ⚠
- p.Ser6Thr Single submitter ⚠
- p.Thr266Ala Single submitter ⚠
- p.Thr291Ser Single submitter
- p.Thr330Met Single submitter ⚠
- p.Thr351Ser Single submitter ⚠
- p.Thr82Ile Single submitter ⚠
- p.Tyr42His Single submitter ⚠
- p.Tyr42Ser Single submitter ⚠
- p.Val111Asp Single submitter ⚠
- p.Val131Met Single submitter ⚠
- p.Val163Ile Single submitter ⚠
- p.Val163Leu Single submitter ⚠
- p.Val211Met Single submitter ⚠
- p.Val250Ala Single submitter ⚠
- p.Val286fs Single submitter
- p.Val287Gly Single submitter ⚠