PADI2 — 104 ClinVar variants
All ClinVar germline PADI2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 89 flagged for review →
5 Benign · 5 Likely benign · 94 Uncertain significance
Full PADI2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 89
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 63
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PADI2 p.Ala149Thr Uncertain significance Multiple submitters
- PADI2 p.Ala138Thr Uncertain significance Single submitter
- PADI2 p.Ala246Thr Uncertain significance Single submitter
- PADI2 p.Ala32Val Uncertain significance Single submitter
- PADI2 p.Arg126Gln Uncertain significance Single submitter
- PADI2 p.Arg168His Uncertain significance Single submitter
- PADI2 p.Arg193Cys Uncertain significance Single submitter
- PADI2 p.Arg233Gly Uncertain significance Single submitter
- PADI2 p.Arg373Gly Uncertain significance Single submitter
- PADI2 p.Arg441Gln Uncertain significance Single submitter
- PADI2 p.Arg441Trp Uncertain significance Single submitter
- PADI2 p.Arg442Lys Uncertain significance Single submitter
- PADI2 p.Arg502Gln Uncertain significance Single submitter
- PADI2 p.Arg54Cys Uncertain significance Single submitter
- PADI2 p.Arg54His Uncertain significance Single submitter
- PADI2 p.Arg652His Uncertain significance Single submitter
- PADI2 p.Asn302Lys Uncertain significance Single submitter
- PADI2 p.Asn551His Uncertain significance Single submitter
- PADI2 p.Asp192Asn Uncertain significance Single submitter
- PADI2 p.Asp578Glu Uncertain significance Single submitter
- PADI2 p.Glu359Lys Uncertain significance Single submitter
- PADI2 p.Glu51Asp Uncertain significance Single submitter
- PADI2 p.Glu535Lys Uncertain significance Single submitter
- PADI2 p.Glu577Ala Uncertain significance Single submitter
- PADI2 p.Glu60Gln Uncertain significance Single submitter
- PADI2 p.Gly254Asp Uncertain significance Single submitter
- PADI2 p.Gly36Arg Uncertain significance Single submitter
- PADI2 p.Gly391Ser Uncertain significance Single submitter
- PADI2 p.Gly432Arg Uncertain significance Single submitter
- PADI2 p.Gly483Ser Uncertain significance Single submitter
- PADI2 p.Gly648Ser Uncertain significance Single submitter
- PADI2 p.His269Gln Uncertain significance Single submitter
- PADI2 p.His509Gln Uncertain significance Single submitter
- PADI2 p.Ile150Leu Uncertain significance Single submitter
- PADI2 p.Ile285Val Uncertain significance Single submitter
- PADI2 p.Ile291Met Uncertain significance Single submitter
- PADI2 p.Ile429Thr Uncertain significance Single submitter
- PADI2 p.Ile513Met Uncertain significance Single submitter
- PADI2 p.Leu111Phe Uncertain significance Single submitter
- PADI2 p.Leu398Phe Uncertain significance Single submitter
- PADI2 p.Leu411Pro Uncertain significance Single submitter
- PADI2 p.Leu559Pro Uncertain significance Single submitter
- PADI2 p.Leu621Pro Uncertain significance Single submitter
- PADI2 p.Met314Leu Uncertain significance Single submitter
- PADI2 p.Phe408Ser Uncertain significance Single submitter
- PADI2 p.Pro281Leu Uncertain significance Single submitter
- PADI2 p.Pro296Leu Uncertain significance Single submitter
- PADI2 p.Ser174Arg Uncertain significance Single submitter
- PADI2 p.Ser271Asn Uncertain significance Single submitter
- PADI2 p.Thr287Ala Uncertain significance Single submitter
- PADI2 p.Thr287Met Uncertain significance Single submitter
- PADI2 p.Thr39Asn Uncertain significance Single submitter
- PADI2 p.Thr484Lys Uncertain significance Single submitter
- PADI2 p.Thr527Ser Uncertain significance Single submitter
- PADI2 p.Thr657Ile Uncertain significance Single submitter
- PADI2 p.Tyr424Cys Uncertain significance Single submitter
- PADI2 p.Val122Met Uncertain significance Single submitter
- PADI2 p.Val172Ile Uncertain significance Single submitter
- PADI2 p.Val238Met Uncertain significance Single submitter
- PADI2 p.Val290Met Uncertain significance Single submitter
- PADI2 p.Val328Met Uncertain significance Single submitter
- PADI2 p.Val382Met Uncertain significance Single submitter
- PADI2 p.Val446Ala Uncertain significance Single submitter
Predictors split 26
The independent predictors disagree with each other — read with care.
- PADI2 p.Arg187Trp Uncertain significance Single submitter
- PADI2 p.Arg293Gln Uncertain significance Single submitter
- PADI2 p.Arg347Cys Uncertain significance Single submitter
- PADI2 p.Arg347His Uncertain significance Single submitter
- PADI2 p.Arg373Gln Uncertain significance Single submitter
- PADI2 p.Arg619Cys Uncertain significance Single submitter
- PADI2 p.Arg619His Uncertain significance Single submitter
- PADI2 p.Arg68Cys Uncertain significance Single submitter
- PADI2 p.Asp156Glu Uncertain significance Single submitter
- PADI2 p.Asp346Asn Uncertain significance Single submitter
- PADI2 p.Gly261Val Uncertain significance Single submitter
- PADI2 p.Gly345Val Uncertain significance Single submitter
- PADI2 p.His44Asp Uncertain significance Single submitter
- PADI2 p.Ile285Phe Uncertain significance Single submitter
- PADI2 p.Leu42Met Uncertain significance Single submitter
- PADI2 p.Leu598Val Uncertain significance Single submitter
- PADI2 p.Lys92Gln Uncertain significance Single submitter
- PADI2 p.Met443Val Uncertain significance Single submitter
- PADI2 p.Met514Ile Uncertain significance Single submitter
- PADI2 p.Phe365Leu Uncertain significance Single submitter
- PADI2 p.Pro366Ala Uncertain significance Single submitter
- PADI2 p.Pro425Leu Uncertain significance Single submitter
- PADI2 p.Ser45Leu Uncertain significance Single submitter
- PADI2 p.Tyr98His Uncertain significance Single submitter
- PADI2 p.Val417Met Uncertain significance Single submitter
- PADI2 p.Val618Met Uncertain significance Single submitter
All PADI2 variants
Benign 5
Likely benign 5
- p.Arg233Gln Multiple submitters
- p.Gln340Ter Single submitter
- p.Glu577Lys Single submitter
- p.Leu437= Single submitter
- p.Leu488Arg Single submitter
Uncertain significance 94
- p.Ala149Thr Multiple submitters ⚠
- p.Ala138Thr Single submitter ⚠
- p.Ala246Thr Single submitter ⚠
- p.Ala32Val Single submitter ⚠
- p.Arg126Gln Single submitter ⚠
- p.Arg168His Single submitter ⚠
- p.Arg187Trp Single submitter ⚠
- p.Arg193Cys Single submitter ⚠
- p.Arg233Gly Single submitter ⚠
- p.Arg293Gln Single submitter ⚠
- p.Arg347Cys Single submitter ⚠
- p.Arg347His Single submitter ⚠
- p.Arg373Gln Single submitter ⚠
- p.Arg373Gly Single submitter ⚠
- p.Arg441Gln Single submitter ⚠
- p.Arg441Trp Single submitter ⚠
- p.Arg442Lys Single submitter ⚠
- p.Arg502Gln Single submitter ⚠
- p.Arg54Cys Single submitter ⚠
- p.Arg54His Single submitter ⚠
- p.Arg552His Single submitter
- p.Arg619Cys Single submitter ⚠
- p.Arg619His Single submitter ⚠
- p.Arg652His Single submitter ⚠
- p.Arg68Cys Single submitter ⚠
- p.Asn302Lys Single submitter ⚠
- p.Asn551His Single submitter ⚠
- p.Asp156Glu Single submitter ⚠
- p.Asp192Asn Single submitter ⚠
- p.Asp346Asn Single submitter ⚠
- p.Asp578Glu Single submitter ⚠
- p.Glu359Lys Single submitter ⚠
- p.Glu51Asp Single submitter ⚠
- p.Glu535Lys Single submitter ⚠
- p.Glu577Ala Single submitter ⚠
- p.Glu60Gln Single submitter ⚠
- p.Gly254Asp Single submitter ⚠
- p.Gly261Val Single submitter ⚠
- p.Gly345Val Single submitter ⚠
- p.Gly36Arg Single submitter ⚠
- p.Gly391Ser Single submitter ⚠
- p.Gly432Arg Single submitter ⚠
- p.Gly483Ser Single submitter ⚠
- p.Gly648Ser Single submitter ⚠
- p.His269Gln Single submitter ⚠
- p.His44Asp Single submitter ⚠
- p.His509Gln Single submitter ⚠
- p.Ile150Leu Single submitter ⚠
- p.Ile285Phe Single submitter ⚠
- p.Ile285Val Single submitter ⚠
- p.Ile291Met Single submitter ⚠
- p.Ile429Thr Single submitter ⚠
- p.Ile513Met Single submitter ⚠
- p.Leu111Phe Single submitter ⚠
- p.Leu398Phe Single submitter ⚠
- p.Leu411Pro Single submitter ⚠
- p.Leu42Met Single submitter ⚠
- p.Leu559Pro Single submitter ⚠
- p.Leu598Val Single submitter ⚠
- p.Leu621Pro Single submitter ⚠
- p.Lys92Gln Single submitter ⚠
- p.Met314Leu Single submitter ⚠
- p.Met443Val Single submitter ⚠
- p.Met514Ile Single submitter ⚠
- p.Phe365Leu Single submitter ⚠
- p.Phe408Ser Single submitter ⚠
- p.Pro281Leu Single submitter ⚠
- p.Pro284Leu Single submitter
- p.Pro296Leu Single submitter ⚠
- p.Pro366Ala Single submitter ⚠
- p.Pro425Leu Single submitter ⚠
- p.Ser174Arg Single submitter ⚠
- p.Ser271Asn Single submitter ⚠
- p.Ser45Leu Single submitter ⚠
- p.Thr287Ala Single submitter ⚠
- p.Thr287Met Single submitter ⚠
- p.Thr39Asn Single submitter ⚠
- p.Thr484Lys Single submitter ⚠
- p.Thr527Ser Single submitter ⚠
- p.Thr657Ile Single submitter ⚠
- p.Tyr424Cys Single submitter ⚠
- p.Tyr98His Single submitter ⚠
- p.Val122Met Single submitter ⚠
- p.Val172Ile Single submitter ⚠
- p.Val238Met Single submitter ⚠
- p.Val252Met Single submitter
- p.Val290Met Single submitter ⚠
- p.Val328Met Single submitter ⚠
- p.Val382Met Single submitter ⚠
- p.Val393Met Single submitter
- p.Val417Met Single submitter ⚠
- p.Val446Ala Single submitter ⚠
- p.Val48Met Single submitter
- p.Val618Met Single submitter ⚠