PAG1 — 55 ClinVar variants
All ClinVar germline PAG1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 46 flagged for review →
1 Benign · 6 Likely benign · 48 Uncertain significance
Full PAG1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 46
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 40
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PAG1 p.Ala25Thr Uncertain significance Single submitter
- PAG1 p.Ala389Thr Uncertain significance Single submitter
- PAG1 p.Arg131Trp Uncertain significance Single submitter
- PAG1 p.Arg237Cys Uncertain significance Single submitter
- PAG1 p.Arg302Trp Uncertain significance Single submitter
- PAG1 p.Arg68Ser Uncertain significance Single submitter
- PAG1 p.Asn241Lys Uncertain significance Single submitter
- PAG1 p.Asp428Gly Uncertain significance Single submitter
- PAG1 p.Asp76Tyr Uncertain significance Single submitter
- PAG1 p.Asp96Asn Uncertain significance Single submitter
- PAG1 p.Cys127Gly Uncertain significance Single submitter
- PAG1 p.Gln238Leu Uncertain significance Single submitter
- PAG1 p.Glu212Ala Uncertain significance Single submitter
- PAG1 p.Glu212Gly Uncertain significance Single submitter
- PAG1 p.Glu280Gly Uncertain significance Single submitter
- PAG1 p.Glu303Ala Uncertain significance Single submitter
- PAG1 p.Glu396Gly Uncertain significance Single submitter
- PAG1 p.Glu397Asp Uncertain significance Single submitter
- PAG1 p.His200Arg Uncertain significance Single submitter
- PAG1 p.Ile30Val Uncertain significance Single submitter
- PAG1 p.Ile420Leu Uncertain significance Single submitter
- PAG1 p.Leu393Pro Uncertain significance Single submitter
- PAG1 p.Leu402Gln Uncertain significance Single submitter
- PAG1 p.Lys235Arg Uncertain significance Single submitter
- PAG1 p.Lys399Asn Uncertain significance Single submitter
- PAG1 p.Met145Val Uncertain significance Single submitter
- PAG1 p.Met175Thr Uncertain significance Single submitter
- PAG1 p.Pro259Ser Uncertain significance Single submitter
- PAG1 p.Ser150Ile Uncertain significance Single submitter
- PAG1 p.Ser244Ile Uncertain significance Single submitter
- PAG1 p.Ser333Leu Uncertain significance Single submitter
- PAG1 p.Ser351Leu Uncertain significance Single submitter
- PAG1 p.Ser371Ile Uncertain significance Single submitter
- PAG1 p.Thr147Met Uncertain significance Single submitter
- PAG1 p.Thr207Ser Uncertain significance Single submitter
- PAG1 p.Thr284Ala Uncertain significance Single submitter
- PAG1 p.Thr284Ile Uncertain significance Single submitter
- PAG1 p.Thr335Arg Uncertain significance Single submitter
- PAG1 p.Tyr417Cys Uncertain significance Single submitter
- PAG1 p.Val142Met Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- PAG1 p.Arg131Gln Uncertain significance Single submitter
- PAG1 p.Arg237His Uncertain significance Single submitter
- PAG1 p.Asn55Lys Uncertain significance Single submitter
- PAG1 p.Gln129Arg Uncertain significance Single submitter
- PAG1 p.Glu164Val Uncertain significance Single submitter
- PAG1 p.Glu186Val Uncertain significance Single submitter
All PAG1 variants
Benign 1
- p.Val151Ala Multiple submitters
Likely benign 6
- p.Thr404Ser Multiple submitters
- c.125+9C>T Single submitter
- p.Ala23Thr Single submitter
- p.Gly276Ala Single submitter
- p.Gly276Glu Single submitter
- p.Ser10Gly Single submitter
Uncertain significance 48
- p.Ala25Thr Single submitter ⚠
- p.Ala389Thr Single submitter ⚠
- p.Arg131Gln Single submitter ⚠
- p.Arg131Trp Single submitter ⚠
- p.Arg237Cys Single submitter ⚠
- p.Arg237His Single submitter ⚠
- p.Arg302Trp Single submitter ⚠
- p.Arg68Ser Single submitter ⚠
- p.Asn241Lys Single submitter ⚠
- p.Asn55Lys Single submitter ⚠
- p.Asp114Glu Single submitter
- p.Asp416Asn Single submitter
- p.Asp428Gly Single submitter ⚠
- p.Asp76Tyr Single submitter ⚠
- p.Asp96Asn Single submitter ⚠
- p.Cys127Gly Single submitter ⚠
- p.Gln129Arg Single submitter ⚠
- p.Gln238Leu Single submitter ⚠
- p.Glu164Val Single submitter ⚠
- p.Glu186Val Single submitter ⚠
- p.Glu212Ala Single submitter ⚠
- p.Glu212Gly Single submitter ⚠
- p.Glu280Gly Single submitter ⚠
- p.Glu303Ala Single submitter ⚠
- p.Glu396Gly Single submitter ⚠
- p.Glu397Asp Single submitter ⚠
- p.His200Arg Single submitter ⚠
- p.Ile30Val Single submitter ⚠
- p.Ile420Leu Single submitter ⚠
- p.Leu393Pro Single submitter ⚠
- p.Leu402Gln Single submitter ⚠
- p.Lys235Arg Single submitter ⚠
- p.Lys399Asn Single submitter ⚠
- p.Met145Val Single submitter ⚠
- p.Met175Thr Single submitter ⚠
- p.Pro259Ser Single submitter ⚠
- p.Ser150Ile Single submitter ⚠
- p.Ser244Ile Single submitter ⚠
- p.Ser333Leu Single submitter ⚠
- p.Ser351Leu Single submitter ⚠
- p.Ser371Ile Single submitter ⚠
- p.Thr147Met Single submitter ⚠
- p.Thr207Ser Single submitter ⚠
- p.Thr284Ala Single submitter ⚠
- p.Thr284Ile Single submitter ⚠
- p.Thr335Arg Single submitter ⚠
- p.Tyr417Cys Single submitter ⚠
- p.Val142Met Single submitter ⚠