PAK4 — 117 ClinVar variants
All ClinVar germline PAK4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 108 flagged for review →
1 Benign · 6 Likely benign · 110 Uncertain significance
Full PAK4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 108
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 92
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PAK4 p.Ala109Asp Uncertain significance Single submitter
- PAK4 p.Ala111Ser Uncertain significance Single submitter
- PAK4 p.Ala125Asp Uncertain significance Single submitter
- PAK4 p.Ala13Ser Uncertain significance Single submitter
- PAK4 p.Ala13Thr Uncertain significance Single submitter
- PAK4 p.Ala13Val Uncertain significance Single submitter
- PAK4 p.Ala154Ser Uncertain significance Single submitter
- PAK4 p.Ala197Val Uncertain significance Single submitter
- PAK4 p.Ala200Thr Uncertain significance Single submitter
- PAK4 p.Ala220Val Uncertain significance Single submitter
- PAK4 p.Ala228Val Uncertain significance Single submitter
- PAK4 p.Ala238Thr Uncertain significance Single submitter
- PAK4 p.Ala256Val Uncertain significance Single submitter
- PAK4 p.Ala275Val Uncertain significance Single submitter
- PAK4 p.Ala306Ser Uncertain significance Single submitter
- PAK4 p.Ala57Thr Uncertain significance Single submitter
- PAK4 p.Ala66Ser Uncertain significance Single submitter
- PAK4 p.Ala66Val Uncertain significance Single submitter
- PAK4 p.Arg110His Uncertain significance Single submitter
- PAK4 p.Arg137Gln Uncertain significance Single submitter
- PAK4 p.Arg152Gln Uncertain significance Single submitter
- PAK4 p.Arg153Gln Uncertain significance Single submitter
- PAK4 p.Arg153Trp Uncertain significance Single submitter
- PAK4 p.Arg159Ser Uncertain significance Single submitter
- PAK4 p.Arg159Thr Uncertain significance Single submitter
- PAK4 p.Arg175Gln Uncertain significance Single submitter
- PAK4 p.Arg203Trp Uncertain significance Single submitter
- PAK4 p.Arg218Gln Uncertain significance Single submitter
- PAK4 p.Arg290Cys Uncertain significance Single submitter
- PAK4 p.Arg290His Uncertain significance Single submitter
- PAK4 p.Arg290Ser Uncertain significance Single submitter
- PAK4 p.Arg294Gln Uncertain significance Single submitter
- PAK4 p.Arg305Gln Uncertain significance Single submitter
- PAK4 p.Arg341Cys Uncertain significance Single submitter
- PAK4 p.Arg355Cys Uncertain significance Single submitter
- PAK4 p.Arg360His Uncertain significance Single submitter
- PAK4 p.Arg37Cys Uncertain significance Single submitter
- PAK4 p.Arg489His Uncertain significance Single submitter
- PAK4 p.Arg528Trp Uncertain significance Single submitter
- PAK4 p.Arg551Cys Uncertain significance Single submitter
- PAK4 p.Asn206Asp Uncertain significance Single submitter
- PAK4 p.Asn230Asp Uncertain significance Single submitter
- PAK4 p.Asn537Ser Uncertain significance Single submitter
- PAK4 p.Asp103Glu Uncertain significance Single submitter
- PAK4 p.Asp451Val Uncertain significance Single submitter
- PAK4 p.Gln426His Uncertain significance Single submitter
- PAK4 p.Gln63His Uncertain significance Single submitter
- PAK4 p.Glu143Gln Uncertain significance Single submitter
- PAK4 p.Glu223Asp Uncertain significance Single submitter
- PAK4 p.Glu361Lys Uncertain significance Single submitter
- PAK4 p.Glu396Gln Uncertain significance Single submitter
- PAK4 p.Glu518Lys Uncertain significance Single submitter
- PAK4 p.Glu88Lys Uncertain significance Single submitter
- PAK4 p.Gly140Val Uncertain significance Single submitter
- PAK4 p.Gly155Ala Uncertain significance Single submitter
- PAK4 p.Gly169Asp Uncertain significance Single submitter
- PAK4 p.Gly222Arg Uncertain significance Single submitter
- PAK4 p.Gly236Ser Uncertain significance Single submitter
- PAK4 p.Gly315Asp Uncertain significance Single submitter
- PAK4 p.Gly328Ser Uncertain significance Single submitter
- PAK4 p.Gly511Arg Uncertain significance Single submitter
- PAK4 p.Gly76Asp Uncertain significance Single submitter
- PAK4 p.His215Pro Uncertain significance Single submitter
- PAK4 p.His28Gln Uncertain significance Single submitter
- PAK4 p.His375Gln Uncertain significance Single submitter
- PAK4 p.His569Gln Uncertain significance Single submitter
- PAK4 p.Ile334Thr Uncertain significance Single submitter
- PAK4 p.Leu237Val Uncertain significance Single submitter
- PAK4 p.Leu391Val Uncertain significance Single submitter
- PAK4 p.Leu84Met Uncertain significance Single submitter
- PAK4 p.Lys442Asn Uncertain significance Single submitter
- PAK4 p.Lys525Arg Uncertain significance Single submitter
- PAK4 p.Met117Ile Uncertain significance Single submitter
- PAK4 p.Pro107Leu Uncertain significance Single submitter
- PAK4 p.Pro121Leu Uncertain significance Single submitter
- PAK4 p.Pro190His Uncertain significance Single submitter
- PAK4 p.Pro232Leu Uncertain significance Single submitter
- PAK4 p.Pro273His Uncertain significance Single submitter
- PAK4 p.Pro274Ala Uncertain significance Single submitter
- PAK4 p.Pro284Ser Uncertain significance Single submitter
- PAK4 p.Pro286Leu Uncertain significance Single submitter
- PAK4 p.Pro317Ala Uncertain significance Single submitter
- PAK4 p.Pro494Ala Uncertain significance Single submitter
- PAK4 p.Ser174Phe Uncertain significance Single submitter
- PAK4 p.Ser244Phe Uncertain significance Single submitter
- PAK4 p.Tyr480Ser Uncertain significance Single submitter
-
PAK4 p.Val21Met
Uncertain significance
Single submitter
hereditary breast ovarian cancer syndrome
- PAK4 p.Val261Gly Uncertain significance Single submitter
- PAK4 p.Val261Met Uncertain significance Single submitter
- PAK4 p.Val420Met Uncertain significance Single submitter
- PAK4 p.Val430Met Uncertain significance Single submitter
-
PAK4 p.Gly502Arg
Uncertain significance
No assertion criteria
prostate cancer
Predictors split 16
The independent predictors disagree with each other — read with care.
- PAK4 p.Arg318His Uncertain significance Single submitter
- PAK4 p.Arg528Gln Uncertain significance Single submitter
- PAK4 p.Arg589Cys Uncertain significance Single submitter
- PAK4 p.Arg5Thr Uncertain significance Single submitter
- PAK4 p.Asp26Asn Uncertain significance Single submitter
- PAK4 p.Gln434Glu Uncertain significance Single submitter
- PAK4 p.Glu399Gln Uncertain significance Single submitter
- PAK4 p.Met526Ile Uncertain significance Single submitter
- PAK4 p.Met585Leu Uncertain significance Single submitter
- PAK4 p.Pro577Leu Uncertain significance Single submitter
- PAK4 p.Ser242Phe Uncertain significance Single submitter
- PAK4 p.Ser247Phe Uncertain significance Single submitter
- PAK4 p.Ser343Leu Uncertain significance Single submitter
- PAK4 p.Thr33Met Uncertain significance Single submitter
- PAK4 p.Thr562Met Uncertain significance Single submitter
- PAK4 p.Tyr208His Uncertain significance Single submitter
All PAK4 variants
Benign 1
- p.Ala573Ser Multiple submitters
Likely benign 6
- p.Arg555Gly Single submitter
- p.Asn517= Single submitter
- p.Gly147Ser Single submitter
- p.Leu475= Single submitter
- p.Leu53= Single submitter
- p.Lys345Arg Single submitter
Uncertain significance 110
- p.Ala109Asp Single submitter ⚠
- p.Ala111Ser Single submitter ⚠
- p.Ala125Asp Single submitter ⚠
- p.Ala13Ser Single submitter ⚠
- p.Ala13Thr Single submitter ⚠
- p.Ala13Val Single submitter ⚠
- p.Ala154Ser Single submitter ⚠
- p.Ala197Val Single submitter ⚠
- p.Ala200Thr Single submitter ⚠
- p.Ala220Val Single submitter ⚠
- p.Ala228Val Single submitter ⚠
- p.Ala238Thr Single submitter ⚠
- p.Ala256Val Single submitter ⚠
- p.Ala275Val Single submitter ⚠
- p.Ala306Ser Single submitter ⚠
- p.Ala57Thr Single submitter ⚠
- p.Ala66Ser Single submitter ⚠
- p.Ala66Val Single submitter ⚠
- p.Arg110His Single submitter ⚠
- p.Arg137Gln Single submitter ⚠
- p.Arg152Gln Single submitter ⚠
- p.Arg153Gln Single submitter ⚠
- p.Arg153Trp Single submitter ⚠
- p.Arg159Ser Single submitter ⚠
- p.Arg159Thr Single submitter ⚠
- p.Arg175Gln Single submitter ⚠
- p.Arg203Trp Single submitter ⚠
- p.Arg218Gln Single submitter ⚠
- p.Arg290Cys Single submitter ⚠
- p.Arg290His Single submitter ⚠
- p.Arg290Ser Single submitter ⚠
- p.Arg294Gln Single submitter ⚠
- p.Arg298Gln Single submitter
- p.Arg305Gln Single submitter ⚠
- p.Arg318His Single submitter ⚠
- p.Arg341Cys Single submitter ⚠
- p.Arg355Cys Single submitter ⚠
- p.Arg360His Single submitter ⚠
- p.Arg37Cys Single submitter ⚠
- p.Arg489His Single submitter ⚠
- p.Arg528Gln Single submitter ⚠
- p.Arg528Trp Single submitter ⚠
- p.Arg551Cys Single submitter ⚠
- p.Arg589Cys Single submitter ⚠
- p.Arg5Thr Single submitter ⚠
- p.Arg8Gln Single submitter
- p.Asn206Asp Single submitter ⚠
- p.Asn230Asp Single submitter ⚠
- p.Asn537Ser Single submitter ⚠
- p.Asp103Glu Single submitter ⚠
- p.Asp26Asn Single submitter ⚠
- p.Asp451Val Single submitter ⚠
- p.Gln426His Single submitter ⚠
- p.Gln434Glu Single submitter ⚠
- p.Gln63His Single submitter ⚠
- p.Glu143Gln Single submitter ⚠
- p.Glu223Asp Single submitter ⚠
- p.Glu361Lys Single submitter ⚠
- p.Glu396Gln Single submitter ⚠
- p.Glu399Gln Single submitter ⚠
- p.Glu518Lys Single submitter ⚠
- p.Glu88Lys Single submitter ⚠
- p.Gly140Val Single submitter ⚠
- p.Gly155Ala Single submitter ⚠
- p.Gly169Asp Single submitter ⚠
- p.Gly222Arg Single submitter ⚠
- p.Gly236Ser Single submitter ⚠
- p.Gly315Asp Single submitter ⚠
- p.Gly328Ser Single submitter ⚠
- p.Gly511Arg Single submitter ⚠
- p.Gly76Asp Single submitter ⚠
- p.His215Pro Single submitter ⚠
- p.His28Gln Single submitter ⚠
- p.His375Gln Single submitter ⚠
- p.His569Gln Single submitter ⚠
- p.Ile334Thr Single submitter ⚠
- p.Leu237Val Single submitter ⚠
- p.Leu391Val Single submitter ⚠
- p.Leu84Met Single submitter ⚠
- p.Lys442Asn Single submitter ⚠
- p.Lys525Arg Single submitter ⚠
- p.Met117Ile Single submitter ⚠
- p.Met526Ile Single submitter ⚠
- p.Met585Leu Single submitter ⚠
- p.Pro107Leu Single submitter ⚠
- p.Pro121Leu Single submitter ⚠
- p.Pro190His Single submitter ⚠
- p.Pro232Leu Single submitter ⚠
- p.Pro273His Single submitter ⚠
- p.Pro274Ala Single submitter ⚠
- p.Pro284Ser Single submitter ⚠
- p.Pro286Leu Single submitter ⚠
- p.Pro317Ala Single submitter ⚠
- p.Pro494Ala Single submitter ⚠
- p.Pro577Leu Single submitter ⚠
- p.Ser174Phe Single submitter ⚠
- p.Ser242Phe Single submitter ⚠
- p.Ser244Phe Single submitter ⚠
- p.Ser247Phe Single submitter ⚠
- p.Ser343Leu Single submitter ⚠
- p.Thr33Met Single submitter ⚠
- p.Thr562Met Single submitter ⚠
- p.Tyr208His Single submitter ⚠
- p.Tyr480Ser Single submitter ⚠
- p.Val21Met Single submitter hereditary breast ovarian cancer syndrome ⚠
- p.Val261Gly Single submitter ⚠
- p.Val261Met Single submitter ⚠
- p.Val420Met Single submitter ⚠
- p.Val430Met Single submitter ⚠
- p.Gly502Arg No assertion criteria prostate cancer ⚠