PAK5 — 93 ClinVar variants
All ClinVar germline PAK5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 85 flagged for review →
5 Benign · 2 Likely benign · 86 Uncertain significance
Full PAK5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 85
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 71
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PAK5 p.Ala120Gly Uncertain significance Single submitter
- PAK5 p.Ala120Val Uncertain significance Single submitter
- PAK5 p.Ala251Val Uncertain significance Single submitter
- PAK5 p.Ala303Thr Uncertain significance Single submitter
- PAK5 p.Ala380Gly Uncertain significance Single submitter
- PAK5 p.Ala651Ser Uncertain significance Single submitter
- PAK5 p.Arg483Gln Uncertain significance Single submitter
- PAK5 p.Arg499Gln Uncertain significance Single submitter
- PAK5 p.Arg581Trp Uncertain significance Single submitter
- PAK5 p.Arg656Trp Uncertain significance Single submitter
- PAK5 p.Arg683Gly Uncertain significance Single submitter
- PAK5 p.Asn274Ser Uncertain significance Single submitter
- PAK5 p.Asp154Asn Uncertain significance Single submitter
- PAK5 p.Asp198Asn Uncertain significance Single submitter
- PAK5 p.Asp204Tyr Uncertain significance Single submitter
- PAK5 p.Asp265Gly Uncertain significance Single submitter
- PAK5 p.Asp334Asn Uncertain significance Single submitter
- PAK5 p.Asp421Tyr Uncertain significance Single submitter
- PAK5 p.Asp533Val Uncertain significance Single submitter
- PAK5 p.Asp625Tyr Uncertain significance Single submitter
- PAK5 p.Asp638Ala Uncertain significance Single submitter
- PAK5 p.Cys549Tyr Uncertain significance Single submitter
- PAK5 p.Glu248Asp Uncertain significance Single submitter
- PAK5 p.Glu323Gly Uncertain significance Single submitter
- PAK5 p.Glu640Lys Uncertain significance Single submitter
- PAK5 p.Gly116Asp Uncertain significance Single submitter
- PAK5 p.Gly353Ser Uncertain significance Single submitter
- PAK5 p.Gly528Ser Uncertain significance Single submitter
- PAK5 p.His202Asn Uncertain significance Single submitter
- PAK5 p.Leu151Ile Uncertain significance Single submitter
- PAK5 p.Leu250Val Uncertain significance Single submitter
- PAK5 p.Leu382Ser Uncertain significance Single submitter
- PAK5 p.Leu449Met Uncertain significance Single submitter
- PAK5 p.Leu482Pro Uncertain significance Single submitter
- PAK5 p.Leu712Phe Uncertain significance Single submitter
- PAK5 p.Lys379Arg Uncertain significance Single submitter
- PAK5 p.Lys6Asn Uncertain significance Single submitter
- PAK5 p.Lys8Asn Uncertain significance Single submitter
- PAK5 p.Met297Arg Uncertain significance Single submitter
- PAK5 p.Met509Thr Uncertain significance Single submitter
- PAK5 p.Met632Ile Uncertain significance Single submitter
- PAK5 p.Met680Leu Uncertain significance Single submitter
- PAK5 p.Phe699Leu Uncertain significance Single submitter
- PAK5 p.Pro158Leu Uncertain significance Single submitter
- PAK5 p.Pro187Ser Uncertain significance Single submitter
- PAK5 p.Pro236Leu Uncertain significance Single submitter
- PAK5 p.Pro295Leu Uncertain significance Single submitter
- PAK5 p.Pro329Thr Uncertain significance Single submitter
- PAK5 p.Pro358Ser Uncertain significance Single submitter
- PAK5 p.Pro413Leu Uncertain significance Single submitter
- PAK5 p.Pro424Ser Uncertain significance Single submitter
- PAK5 p.Pro607Leu Uncertain significance Single submitter
- PAK5 p.Pro61Thr Uncertain significance Single submitter
- PAK5 p.Ser132Cys Uncertain significance Single submitter
- PAK5 p.Ser150Asn Uncertain significance Single submitter
- PAK5 p.Ser213Asn Uncertain significance Single submitter
- PAK5 p.Ser225Thr Uncertain significance Single submitter
- PAK5 p.Ser237Tyr Uncertain significance Single submitter
- PAK5 p.Ser249Asn Uncertain significance Single submitter
- PAK5 p.Ser391Asn Uncertain significance Single submitter
- PAK5 p.Ser571Asn Uncertain significance Single submitter
- PAK5 p.Ser670Pro Uncertain significance Single submitter
- PAK5 p.Thr127Ala Uncertain significance Single submitter
- PAK5 p.Thr239Ser Uncertain significance Single submitter
- PAK5 p.Thr242Asn Uncertain significance Single submitter
- PAK5 p.Tyr181Cys Uncertain significance Single submitter
- PAK5 p.Tyr252Phe Uncertain significance Single submitter
- PAK5 p.Tyr400His Uncertain significance Single submitter
- PAK5 p.Tyr411Phe Uncertain significance Single submitter
- PAK5 p.Val710Ile Uncertain significance Single submitter
- PAK5 p.Val71Ile Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- PAK5 p.Arg283Leu Uncertain significance Single submitter
- PAK5 p.Arg283Trp Uncertain significance Single submitter
- PAK5 p.Arg285Ser Uncertain significance Single submitter
- PAK5 p.Arg662Ser Uncertain significance Single submitter
- PAK5 p.Arg674Trp Uncertain significance Single submitter
- PAK5 p.Gly353Arg Uncertain significance Single submitter
- PAK5 p.Gly675Val Uncertain significance Single submitter
- PAK5 p.Lys269Asn Uncertain significance Single submitter
- PAK5 p.Pro319Leu Uncertain significance Single submitter
- PAK5 p.Ser415Arg Uncertain significance Single submitter
- PAK5 p.Ser686Cys Uncertain significance Single submitter
- PAK5 p.Ser707Pro Uncertain significance Single submitter
- PAK5 p.Thr690Ala Uncertain significance Single submitter
- PAK5 p.Tyr350Asp Uncertain significance Single submitter
All PAK5 variants
Benign 5
Likely benign 2
- p.Ala197Val Single submitter
- p.Gln130= Single submitter
Uncertain significance 86
- p.Ala120Gly Single submitter ⚠
- p.Ala120Val Single submitter ⚠
- p.Ala251Val Single submitter ⚠
- p.Ala303Thr Single submitter ⚠
- p.Ala380Gly Single submitter ⚠
- p.Ala651Ser Single submitter ⚠
- p.Arg283Leu Single submitter ⚠
- p.Arg283Trp Single submitter ⚠
- p.Arg285Ser Single submitter ⚠
- p.Arg483Gln Single submitter ⚠
- p.Arg499Gln Single submitter ⚠
- p.Arg581Trp Single submitter ⚠
- p.Arg656Trp Single submitter ⚠
- p.Arg662Ser Single submitter ⚠
- p.Arg674Trp Single submitter ⚠
- p.Arg683Gly Single submitter ⚠
- p.Asn274Ser Single submitter ⚠
- p.Asp154Asn Single submitter ⚠
- p.Asp198Asn Single submitter ⚠
- p.Asp204Tyr Single submitter ⚠
- p.Asp265Gly Single submitter ⚠
- p.Asp334Asn Single submitter ⚠
- p.Asp421Tyr Single submitter ⚠
- p.Asp533Val Single submitter ⚠
- p.Asp625Tyr Single submitter ⚠
- p.Asp638Ala Single submitter ⚠
- p.Cys549Tyr Single submitter ⚠
- p.Glu248Asp Single submitter ⚠
- p.Glu323Gly Single submitter ⚠
- p.Glu640Lys Single submitter ⚠
- p.Gly116Asp Single submitter ⚠
- p.Gly353Arg Single submitter ⚠
- p.Gly353Ser Single submitter ⚠
- p.Gly528Ser Single submitter ⚠
- p.Gly675Val Single submitter ⚠
- p.His202Asn Single submitter ⚠
- p.Leu151Ile Single submitter ⚠
- p.Leu250Val Single submitter ⚠
- p.Leu382Ser Single submitter ⚠
- p.Leu449Met Single submitter ⚠
- p.Leu482Pro Single submitter ⚠
- p.Leu712Phe Single submitter ⚠
- p.Lys269Asn Single submitter ⚠
- p.Lys363fs Single submitter
- p.Lys379Arg Single submitter ⚠
- p.Lys6Asn Single submitter ⚠
- p.Lys8Asn Single submitter ⚠
- p.Met297Arg Single submitter ⚠
- p.Met509Thr Single submitter ⚠
- p.Met632Ile Single submitter ⚠
- p.Met680Leu Single submitter ⚠
- p.Phe699Leu Single submitter ⚠
- p.Pro158Leu Single submitter ⚠
- p.Pro187Ser Single submitter ⚠
- p.Pro236Leu Single submitter ⚠
- p.Pro295Leu Single submitter ⚠
- p.Pro319Leu Single submitter ⚠
- p.Pro329Thr Single submitter ⚠
- p.Pro358Ser Single submitter ⚠
- p.Pro413Leu Single submitter ⚠
- p.Pro424Ser Single submitter ⚠
- p.Pro607Leu Single submitter ⚠
- p.Pro61Thr Single submitter ⚠
- p.Ser132Cys Single submitter ⚠
- p.Ser150Asn Single submitter ⚠
- p.Ser213Asn Single submitter ⚠
- p.Ser225Thr Single submitter ⚠
- p.Ser237Tyr Single submitter ⚠
- p.Ser249Asn Single submitter ⚠
- p.Ser391Asn Single submitter ⚠
- p.Ser415Arg Single submitter ⚠
- p.Ser571Asn Single submitter ⚠
- p.Ser670Pro Single submitter ⚠
- p.Ser686Cys Single submitter ⚠
- p.Ser707Pro Single submitter ⚠
- p.Thr127Ala Single submitter ⚠
- p.Thr239Ser Single submitter ⚠
- p.Thr242Asn Single submitter ⚠
- p.Thr690Ala Single submitter ⚠
- p.Tyr181Cys Single submitter ⚠
- p.Tyr252Phe Single submitter ⚠
- p.Tyr350Asp Single submitter ⚠
- p.Tyr400His Single submitter ⚠
- p.Tyr411Phe Single submitter ⚠
- p.Val710Ile Single submitter ⚠
- p.Val71Ile Single submitter ⚠