PAM — 88 ClinVar variants

All ClinVar germline PAM variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 71 flagged for review →

7 Benign · 1 Benign/Likely benign · 4 Likely benign · 76 Uncertain significance

Full PAM gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 71

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 60

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 11

The independent predictors disagree with each other — read with care.

All PAM variants

Benign 7

c.1804-5A>T Single submitter
c.443-5T>C Single submitter
p.Asp649= Single submitter
p.Glu491Asp Single submitter
p.Pro192Leu Single submitter
p.Pro350= Single submitter
p.Val49Leu Single submitter

Benign/Likely benign 1

p.Phe31Tyr Multiple submitters

Likely benign 4

p.Arg144Gln Single submitter
p.Lys368= Single submitter
p.Ser735= Single submitter
p.Val384= Single submitter

Uncertain significance 76

p.Ala58Thr Single submitter ⚠
p.Ala787Gly Single submitter ⚠
p.Ala787Val Single submitter ⚠
p.Arg175Thr Single submitter ⚠
p.Arg776His Single submitter ⚠
p.Arg80Gln Single submitter ⚠
p.Arg888Gln Single submitter ⚠
p.Asn428Tyr Single submitter ⚠
p.Asn745Ser Single submitter ⚠
p.Asn840Lys Single submitter ⚠
p.Asp180Tyr Single submitter ⚠
p.Asp277Gly Single submitter ⚠
p.Asp403Asn Single submitter ⚠
p.Asp589Gly Single submitter ⚠
p.Asp639Gly Single submitter ⚠
p.Asp770Glu Single submitter ⚠
p.Cys699Phe Single submitter ⚠
p.Cys699Tyr Single submitter ⚠
p.Glu213Gly Single submitter ⚠
p.Glu319Gln Single submitter ⚠
p.Glu382Lys Single submitter ⚠
p.Glu500Ala Single submitter ⚠
p.Gly506Arg Single submitter ⚠
p.Gly706Asp Single submitter ⚠
p.Gly728Arg Single submitter ⚠
p.Gly746Trp Single submitter ⚠
p.His230Asn Single submitter ⚠
p.His230Gln Single submitter ⚠
p.His300Tyr Single submitter ⚠
p.His362Tyr Single submitter ⚠
p.His446Arg Single submitter ⚠
p.His529Leu Single submitter ⚠
p.His724Gln Single submitter
p.Ile314Val Single submitter ⚠
p.Ile52Val Single submitter ⚠
p.Ile795Leu Single submitter ⚠
p.Ile827Val Single submitter ⚠
p.Leu284Arg Single submitter ⚠
p.Leu880Pro Single submitter ⚠
p.Lys147Arg Single submitter ⚠
p.Lys460Arg Single submitter ⚠
p.Met355Thr Single submitter ⚠
p.Met77Thr Single submitter ⚠
p.Met79Val Single submitter ⚠
p.Met850Ile Single submitter ⚠
p.Phe338Tyr Single submitter
p.Phe683Ile Single submitter ⚠
p.Pro146Ala Single submitter ⚠
p.Pro194Ser Single submitter
p.Pro228Thr Single submitter ⚠
p.Pro348Ala Single submitter ⚠
p.Pro607Ser Single submitter ⚠
p.Pro64Ala Single submitter
p.Pro738Thr Single submitter ⚠
p.Ser113Pro Single submitter ⚠
p.Ser172Gly Single submitter ⚠
p.Ser466Ala Single submitter ⚠
p.Ser662Gly Single submitter ⚠
p.Ser677Cys Single submitter ⚠
p.Ser764Phe Single submitter ⚠
p.Ser862Leu Single submitter ⚠
p.Thr558Ala Single submitter ⚠
p.Thr871Asn Single submitter ⚠
p.Tyr224Cys Single submitter ⚠
p.Tyr391Cys Single submitter ⚠
p.Tyr592Asn Single submitter ⚠
p.Val272Met Single submitter ⚠
p.Val324Asp Single submitter ⚠
p.Val384Ala Single submitter ⚠
p.Val384Gly Single submitter ⚠
p.Val404Asp Single submitter ⚠
p.Val514Ile Single submitter ⚠
p.Val719Gly Single submitter ⚠
p.Val744Leu Single submitter
p.Val793Ala Single submitter ⚠
p.Val89Met Single submitter ⚠