PARD3 — 225 ClinVar variants
All ClinVar germline PARD3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 173 flagged for review →
2 Pathogenic · 1 Conflicting · 14 Benign · 1 Benign/Likely benign · 31 Likely benign · 176 Uncertain significance
Full PARD3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 173
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors vs ClinVar 1
ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.
-
PARD3 p.Asp780Gly
Pathogenic
No assertion criteria
neural tube defect
Predictors agree, ClinVar conflicts 1
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
Predictors lean, ClinVar uncertain 128
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PARD3 p.Ala1062Thr Uncertain significance Single submitter
- PARD3 p.Ala1337Val Uncertain significance Single submitter
- PARD3 p.Ala177Val Uncertain significance Single submitter
- PARD3 p.Ala39Thr Uncertain significance Single submitter
- PARD3 p.Ala405Gly Uncertain significance Single submitter
- PARD3 p.Ala434Thr Uncertain significance Single submitter
- PARD3 p.Ala615Thr Uncertain significance Single submitter
- PARD3 p.Ala793Gly Uncertain significance Single submitter
- PARD3 p.Ala814Thr Uncertain significance Single submitter
- PARD3 p.Arg1000Ser Uncertain significance Single submitter
- PARD3 p.Arg1027Gln Uncertain significance Single submitter
- PARD3 p.Arg1050Thr Uncertain significance Single submitter
- PARD3 p.Arg1065Gln Uncertain significance Single submitter
- PARD3 p.Arg1070Gln Uncertain significance Single submitter
- PARD3 p.Arg1075His Uncertain significance Single submitter
- PARD3 p.Arg1115Gln Uncertain significance Single submitter
- PARD3 p.Arg1131Gln Uncertain significance Single submitter
- PARD3 p.Arg1170Cys Uncertain significance Single submitter
- PARD3 p.Arg1172Gln Uncertain significance Single submitter
- PARD3 p.Arg1204Gln Uncertain significance Single submitter
- PARD3 p.Arg172His Uncertain significance Single submitter
- PARD3 p.Arg249Cys Uncertain significance Single submitter
- PARD3 p.Arg249His Uncertain significance Single submitter
- PARD3 p.Arg294Pro Uncertain significance Single submitter
- PARD3 p.Arg345His Uncertain significance Single submitter
-
PARD3 p.Arg349His
Uncertain significance
Single submitter
neural tube defect
- PARD3 p.Arg381Cys Uncertain significance Single submitter
- PARD3 p.Arg381His Uncertain significance Single submitter
- PARD3 p.Arg407Gln Uncertain significance Single submitter
- PARD3 p.Arg50His Uncertain significance Single submitter
- PARD3 p.Arg554Gly Uncertain significance Single submitter
- PARD3 p.Arg637Gln Uncertain significance Single submitter
- PARD3 p.Arg9Gly Uncertain significance Single submitter
- PARD3 p.Asn362Asp Uncertain significance Single submitter
- PARD3 p.Asn375Ser Uncertain significance Single submitter
- PARD3 p.Asn688Asp Uncertain significance Single submitter
- PARD3 p.Asp502Glu Uncertain significance Single submitter
- PARD3 p.Asp753Gly Uncertain significance Single submitter
- PARD3 p.Asp856Glu Uncertain significance Single submitter
- PARD3 p.Asp864His Uncertain significance Single submitter
- PARD3 p.Asp865Glu Uncertain significance Single submitter
- PARD3 p.Gln1057Arg Uncertain significance Single submitter
-
PARD3 p.Gln1061Glu
Uncertain significance
Single submitter
primary ovarian failure
- PARD3 p.Gln1217Glu Uncertain significance Single submitter
- PARD3 p.Gln1293Glu Uncertain significance Single submitter
- PARD3 p.Gln1314His Uncertain significance Single submitter
- PARD3 p.Gln29Glu Uncertain significance Single submitter
- PARD3 p.Gln414Pro Uncertain significance Single submitter
- PARD3 p.Gln974Leu Uncertain significance Single submitter
- PARD3 p.Glu1252Gly Uncertain significance Single submitter
- PARD3 p.Glu1302Gln Uncertain significance Single submitter
- PARD3 p.Glu1302Lys Uncertain significance Single submitter
- PARD3 p.Gly1036Ser Uncertain significance Single submitter
- PARD3 p.Gly1096Glu Uncertain significance Single submitter
- PARD3 p.Gly109Asp Uncertain significance Single submitter
- PARD3 p.Gly1103Val Uncertain significance Single submitter
- PARD3 p.Gly1117Glu Uncertain significance Single submitter
- PARD3 p.Gly1261Ala Uncertain significance Single submitter
- PARD3 p.Gly1265Ser Uncertain significance Single submitter
- PARD3 p.Gly1348Ala Uncertain significance Single submitter
- PARD3 p.Gly150Ser Uncertain significance Single submitter
- PARD3 p.Gly259Asp Uncertain significance Single submitter
- PARD3 p.Gly600Asp Uncertain significance Single submitter
- PARD3 p.Gly674Glu Uncertain significance Single submitter
- PARD3 p.His1118Tyr Uncertain significance Single submitter
- PARD3 p.His262Leu Uncertain significance Single submitter
- PARD3 p.His342Tyr Uncertain significance Single submitter
- PARD3 p.His426Arg Uncertain significance Single submitter
- PARD3 p.His716Arg Uncertain significance Single submitter
- PARD3 p.Ile1038Met Uncertain significance Single submitter
- PARD3 p.Ile103Arg Uncertain significance Single submitter
- PARD3 p.Ile103Leu Uncertain significance Single submitter
- PARD3 p.Ile1040Val Uncertain significance Single submitter
- PARD3 p.Ile149Thr Uncertain significance Single submitter
- PARD3 p.Ile27Val Uncertain significance Single submitter
- PARD3 p.Ile482Val Uncertain significance Single submitter
- PARD3 p.Ile576Val Uncertain significance Single submitter
- PARD3 p.Ile703Thr Uncertain significance Single submitter
- PARD3 p.Leu180Arg Uncertain significance Single submitter
- PARD3 p.Leu766Arg Uncertain significance Single submitter
- PARD3 p.Leu770Val Uncertain significance Single submitter
- PARD3 p.Leu860Arg Uncertain significance Single submitter
- PARD3 p.Lys1010Arg Uncertain significance Single submitter
- PARD3 p.Lys168Arg Uncertain significance Single submitter
- PARD3 p.Lys231Arg Uncertain significance Single submitter
- PARD3 p.Lys741Glu Uncertain significance Single submitter
- PARD3 p.Met1094Ile Uncertain significance Single submitter
- PARD3 p.Met1119Val Uncertain significance Single submitter
- PARD3 p.Met1120Arg Uncertain significance Single submitter
- PARD3 p.Met343Leu Uncertain significance Single submitter
- PARD3 p.Pro1179Thr Uncertain significance Single submitter
- PARD3 p.Pro1185Leu Uncertain significance Single submitter
- PARD3 p.Pro1243His Uncertain significance Single submitter
- PARD3 p.Pro1300Ser Uncertain significance Single submitter
- PARD3 p.Pro411Leu Uncertain significance Single submitter
- PARD3 p.Pro427Thr Uncertain significance Single submitter
- PARD3 p.Pro42Ala Uncertain significance Single submitter
- PARD3 p.Pro432Ser Uncertain significance Single submitter
- PARD3 p.Pro435Ala Uncertain significance Single submitter
- PARD3 p.Pro696Leu Uncertain significance Single submitter
- PARD3 p.Pro702Ser Uncertain significance Single submitter
- PARD3 p.Ser1231Leu Uncertain significance Single submitter
- PARD3 p.Ser1231Pro Uncertain significance Single submitter
- PARD3 p.Ser1242Tyr Uncertain significance Single submitter
- PARD3 p.Ser220Leu Uncertain significance Single submitter
- PARD3 p.Ser386Arg Uncertain significance Single submitter
- PARD3 p.Ser428Leu Uncertain significance Single submitter
- PARD3 p.Ser448Arg Uncertain significance Single submitter
- PARD3 p.Ser449Gly Uncertain significance Single submitter
- PARD3 p.Ser533Asn Uncertain significance Single submitter
- PARD3 p.Ser720Gly Uncertain significance Single submitter
- PARD3 p.Thr1035Met Uncertain significance Single submitter
- PARD3 p.Thr1344Asn Uncertain significance Single submitter
- PARD3 p.Thr258Met Uncertain significance Single submitter
- PARD3 p.Thr445Lys Uncertain significance Single submitter
- PARD3 p.Thr445Met Uncertain significance Single submitter
- PARD3 p.Thr468Ile Uncertain significance Single submitter
- PARD3 p.Thr569Met Uncertain significance Single submitter
- PARD3 p.Thr705Ile Uncertain significance Single submitter
- PARD3 p.Thr786Met Uncertain significance Single submitter
- PARD3 p.Tyr1095Cys Uncertain significance Single submitter
- PARD3 p.Val1196Leu Uncertain significance Single submitter
- PARD3 p.Val1196Met Uncertain significance Single submitter
- PARD3 p.Val1313Leu Uncertain significance Single submitter
- PARD3 p.Val250Phe Uncertain significance Single submitter
-
PARD3 p.Cys191Phe
Uncertain significance
No assertion criteria
prostate cancer
-
PARD3 p.Cys191Trp
Uncertain significance
No assertion criteria
prostate cancer
-
PARD3 p.Met228Ile
Uncertain significance
No assertion criteria
prostate cancer
Predictors split 43
The independent predictors disagree with each other — read with care.
- PARD3 p.Ala1337Pro Uncertain significance Single submitter
- PARD3 p.Arg1027Gly Uncertain significance Single submitter
- PARD3 p.Arg1070Leu Uncertain significance Single submitter
- PARD3 p.Arg1075Cys Uncertain significance Single submitter
- PARD3 p.Arg1223Trp Uncertain significance Single submitter
- PARD3 p.Arg1326Gln Uncertain significance Single submitter
- PARD3 p.Arg336Ser Uncertain significance Single submitter
- PARD3 p.Arg35Trp Uncertain significance Single submitter
- PARD3 p.Arg609Gln Uncertain significance Single submitter
- PARD3 p.Arg673Gln Uncertain significance Single submitter
- PARD3 p.Arg822His Uncertain significance Single submitter
- PARD3 p.Asn671Ser Uncertain significance Single submitter
- PARD3 p.Asn749Thr Uncertain significance Single submitter
- PARD3 p.Asp754Gly Uncertain significance Single submitter
- PARD3 p.Asp772Gly Uncertain significance Single submitter
- PARD3 p.Asp83Tyr Uncertain significance Single submitter
- PARD3 p.Asp927Asn Uncertain significance Single submitter
- PARD3 p.Asp948Glu Uncertain significance Single submitter
- PARD3 p.Gln29Lys Uncertain significance Single submitter
- PARD3 p.Glu669Asp Uncertain significance Single submitter
- PARD3 p.Gly1012Arg Uncertain significance Single submitter
- PARD3 p.Gly1323Trp Uncertain significance Single submitter
- PARD3 p.Gly296Val Uncertain significance Single submitter
- PARD3 p.Gly783Glu Uncertain significance Single submitter
- PARD3 p.Gly87Arg Uncertain significance Single submitter
- PARD3 p.Gly915Asp Uncertain significance Single submitter
- PARD3 p.Gly941Arg Uncertain significance Single submitter
- PARD3 p.Gly97Ser Uncertain significance Single submitter
- PARD3 p.Lys996Asn Uncertain significance Single submitter
- PARD3 p.Met1020Lys Uncertain significance Single submitter
- PARD3 p.Met136Ile Uncertain significance Single submitter
- PARD3 p.Phe589Leu Uncertain significance Single submitter
- PARD3 p.Pro1254His Uncertain significance Single submitter
- PARD3 p.Ser745Phe Uncertain significance Single submitter
- PARD3 p.Ser872Arg Uncertain significance Single submitter
- PARD3 p.Ser885Asn Uncertain significance Single submitter
- PARD3 p.Thr579Ile Uncertain significance Single submitter
- PARD3 p.Thr944Ile Uncertain significance Single submitter
- PARD3 p.Thr949Pro Uncertain significance Single submitter
- PARD3 p.Tyr1077Cys Uncertain significance Single submitter
- PARD3 p.Val12Met Uncertain significance Single submitter
- PARD3 p.Val14Met Uncertain significance Single submitter
-
PARD3 p.Pro910Gln
Pathogenic
No assertion criteria
neural tube defect
All PARD3 variants
Pathogenic 2
- p.Asp780Gly No assertion criteria neural tube defect ⚠
- p.Pro910Gln No assertion criteria neural tube defect ⚠
Conflicting classifications of pathogenicity 1
- p.Ser417Phe Single submitter ⚠
Benign 14
- c.2560+10A>G Multiple submitters
- p.Ala934Val Multiple submitters
- p.Glu107Asp Multiple submitters
- p.Ser798Asn Multiple submitters
- p.His86= Single submitter
- p.Leu587= Single submitter
- c.*4C>T No assertion criteria PARD3-related disorder
- p.Arg1191= No assertion criteria PARD3-related disorder
- p.Gly1097Arg No assertion criteria PARD3-related disorder
- p.Ser886= No assertion criteria PARD3-related disorder
- p.Thr1187Met No assertion criteria PARD3-related disorder
- p.Thr583= No assertion criteria PARD3-related disorder
- p.Thr755= No assertion criteria PARD3-related disorder
- p.Thr992= No assertion criteria PARD3-related disorder
Benign/Likely benign 1
- p.Glu1252= Multiple submitters
Likely benign 31
- c.120+7G>A Single submitter
- p.Ala1319Thr Single submitter
- p.Asn1273= Single submitter
- p.Asn247Ser Single submitter
- p.Glu276= Single submitter
- p.His314Gln Single submitter
- p.Ile703Val Single submitter
- p.Ser292Thr Single submitter
- p.Ser824= Single submitter
- p.Val1098Ile Single submitter
- p.Val113= Single submitter
- c.120+10_120+33del No assertion criteria PARD3-related disorder
- c.2068-7T>C No assertion criteria PARD3-related disorder
- c.3419+8C>T No assertion criteria PARD3-related disorder
- c.715-4C>T No assertion criteria PARD3-related disorder
- p.Ala93= No assertion criteria PARD3-related disorder
- p.Arg987= No assertion criteria PARD3-related disorder
- p.Asn452Asp No assertion criteria PARD3-related disorder
- p.Cys191= No assertion criteria PARD3-related disorder
- p.Glu1066Gln No assertion criteria PARD3-related disorder
- p.Glu946= No assertion criteria PARD3-related disorder
- p.Gly956= No assertion criteria PARD3-related disorder
- p.Ile415Thr No assertion criteria PARD3-related disorder
- p.Ile926= No assertion criteria PARD3-related disorder
- p.Lys981Arg No assertion criteria PARD3-related disorder
- p.Pro1179= No assertion criteria PARD3-related disorder
- p.Pro1181= No assertion criteria PARD3-related disorder
- p.Pro910= No assertion criteria PARD3-related disorder
- p.Ser1233= No assertion criteria PARD3-related disorder
- p.Ser417= No assertion criteria PARD3-related disorder
- p.Thr786= No assertion criteria PARD3-related disorder
Uncertain significance 176
- p.Ala1062Thr Single submitter ⚠
- p.Ala1337Pro Single submitter ⚠
- p.Ala1337Val Single submitter ⚠
- p.Ala177Val Single submitter ⚠
- p.Ala39Thr Single submitter ⚠
- p.Ala405Gly Single submitter ⚠
- p.Ala434Thr Single submitter ⚠
- p.Ala615Thr Single submitter ⚠
- p.Ala793Gly Single submitter ⚠
- p.Ala814Thr Single submitter ⚠
- p.Arg1000Ser Single submitter ⚠
- p.Arg1027Gln Single submitter ⚠
- p.Arg1027Gly Single submitter ⚠
- p.Arg1050Thr Single submitter ⚠
- p.Arg1065Gln Single submitter ⚠
- p.Arg1070Gln Single submitter ⚠
- p.Arg1070Leu Single submitter ⚠
- p.Arg1075Cys Single submitter ⚠
- p.Arg1075His Single submitter ⚠
- p.Arg1115Gln Single submitter ⚠
- p.Arg1131Gln Single submitter ⚠
- p.Arg1170Cys Single submitter ⚠
- p.Arg1172Gln Single submitter ⚠
- p.Arg1204Gln Single submitter ⚠
- p.Arg1223Trp Single submitter ⚠
- p.Arg1326Gln Single submitter ⚠
- p.Arg172His Single submitter ⚠
- p.Arg204Trp Single submitter
- p.Arg249Cys Single submitter ⚠
- p.Arg249His Single submitter ⚠
- p.Arg294Pro Single submitter ⚠
- p.Arg336Ser Single submitter ⚠
- p.Arg345His Single submitter ⚠
- p.Arg349His Single submitter neural tube defect ⚠
- p.Arg35Trp Single submitter ⚠
- p.Arg381Cys Single submitter ⚠
- p.Arg381His Single submitter ⚠
- p.Arg407Gln Single submitter ⚠
- p.Arg504Ter Single submitter
- p.Arg50His Single submitter ⚠
- p.Arg554Gly Single submitter ⚠
- p.Arg609Gln Single submitter ⚠
- p.Arg637Gln Single submitter ⚠
- p.Arg673Gln Single submitter ⚠
- p.Arg822His Single submitter ⚠
- p.Arg845Ter Single submitter
- p.Arg9Gly Single submitter ⚠
- p.Asn362Asp Single submitter ⚠
- p.Asn375Ser Single submitter ⚠
- p.Asn671Ser Single submitter ⚠
- p.Asn688Asp Single submitter ⚠
- p.Asn749Thr Single submitter ⚠
- p.Asp502Glu Single submitter ⚠
- p.Asp753Gly Single submitter ⚠
- p.Asp754Gly Single submitter ⚠
- p.Asp772Gly Single submitter ⚠
- p.Asp83Tyr Single submitter ⚠
- p.Asp856Glu Single submitter ⚠
- p.Asp864His Single submitter ⚠
- p.Asp865Glu Single submitter ⚠
- p.Asp927Asn Single submitter ⚠
- p.Asp948Glu Single submitter ⚠
- p.Gln1057Arg Single submitter ⚠
- p.Gln1061Glu Single submitter primary ovarian failure ⚠
- p.Gln1217Glu Single submitter ⚠
- p.Gln1293Glu Single submitter ⚠
- p.Gln1314His Single submitter ⚠
- p.Gln29Glu Single submitter ⚠
- p.Gln29Lys Single submitter ⚠
- p.Gln414Pro Single submitter ⚠
- p.Gln974Leu Single submitter ⚠
- p.Glu1252Gly Single submitter ⚠
- p.Glu1302Gln Single submitter ⚠
- p.Glu1302Lys Single submitter ⚠
- p.Glu367Gln Single submitter
- p.Glu669Asp Single submitter ⚠
- p.Gly1012Arg Single submitter ⚠
- p.Gly1036Ser Single submitter ⚠
- p.Gly1096Glu Single submitter ⚠
- p.Gly109Asp Single submitter ⚠
- p.Gly1103Val Single submitter ⚠
- p.Gly1117Glu Single submitter ⚠
- p.Gly1261Ala Single submitter ⚠
- p.Gly1265Ser Single submitter ⚠
- p.Gly1323Trp Single submitter ⚠
- p.Gly1348Ala Single submitter ⚠
- p.Gly150Ser Single submitter ⚠
- p.Gly259Asp Single submitter ⚠
- p.Gly296Val Single submitter ⚠
- p.Gly457Ala Single submitter
- p.Gly600Asp Single submitter ⚠
- p.Gly674Glu Single submitter ⚠
- p.Gly783Glu Single submitter ⚠
- p.Gly87Arg Single submitter ⚠
- p.Gly915Asp Single submitter ⚠
- p.Gly941Arg Single submitter ⚠
- p.Gly97Ser Single submitter ⚠
- p.His1118Tyr Single submitter ⚠
- p.His262Leu Single submitter ⚠
- p.His342Tyr Single submitter ⚠
- p.His426Arg Single submitter ⚠
- p.His716Arg Single submitter ⚠
- p.Ile1038Met Single submitter ⚠
- p.Ile103Arg Single submitter ⚠
- p.Ile103Leu Single submitter ⚠
- p.Ile1040Val Single submitter ⚠
- p.Ile149Thr Single submitter ⚠
- p.Ile27Val Single submitter ⚠
- p.Ile482Val Single submitter ⚠
- p.Ile576Val Single submitter ⚠
- p.Ile703Thr Single submitter ⚠
- p.Leu180Arg Single submitter ⚠
- p.Leu766Arg Single submitter ⚠
- p.Leu770Val Single submitter ⚠
- p.Leu860Arg Single submitter ⚠
- p.Lys1010Arg Single submitter ⚠
- p.Lys168Arg Single submitter ⚠
- p.Lys231Arg Single submitter ⚠
- p.Lys741Glu Single submitter ⚠
- p.Lys996Asn Single submitter ⚠
- p.Met1020Lys Single submitter ⚠
- p.Met1094Ile Single submitter ⚠
- p.Met1119Val Single submitter ⚠
- p.Met1120Arg Single submitter ⚠
- p.Met136Ile Single submitter ⚠
- p.Met343Leu Single submitter ⚠
- p.Phe589Leu Single submitter ⚠
- p.Pro1179Thr Single submitter ⚠
- p.Pro1185Leu Single submitter ⚠
- p.Pro1243His Single submitter ⚠
- p.Pro1254His Single submitter ⚠
- p.Pro1300Ser Single submitter ⚠
- p.Pro411Leu Single submitter ⚠
- p.Pro427Thr Single submitter ⚠
- p.Pro42Ala Single submitter ⚠
- p.Pro432Ser Single submitter ⚠
- p.Pro435Ala Single submitter ⚠
- p.Pro696Leu Single submitter ⚠
- p.Pro702Ser Single submitter ⚠
- p.Ser1231Leu Single submitter ⚠
- p.Ser1231Pro Single submitter ⚠
- p.Ser1242Tyr Single submitter ⚠
- p.Ser143Thr Single submitter
- p.Ser220Leu Single submitter ⚠
- p.Ser386Arg Single submitter ⚠
- p.Ser428Leu Single submitter ⚠
- p.Ser448Arg Single submitter ⚠
- p.Ser449Gly Single submitter ⚠
- p.Ser533Asn Single submitter ⚠
- p.Ser720Gly Single submitter ⚠
- p.Ser745Phe Single submitter ⚠
- p.Ser872Arg Single submitter ⚠
- p.Ser885Asn Single submitter ⚠
- p.Thr1035Met Single submitter ⚠
- p.Thr1344Asn Single submitter ⚠
- p.Thr258Met Single submitter ⚠
- p.Thr445Lys Single submitter ⚠
- p.Thr445Met Single submitter ⚠
- p.Thr468Ile Single submitter ⚠
- p.Thr569Met Single submitter ⚠
- p.Thr579Ile Single submitter ⚠
- p.Thr705Ile Single submitter ⚠
- p.Thr786Met Single submitter ⚠
- p.Thr944Ile Single submitter ⚠
- p.Thr949Pro Single submitter ⚠
- p.Tyr1077Cys Single submitter ⚠
- p.Tyr1095Cys Single submitter ⚠
- p.Val1196Leu Single submitter ⚠
- p.Val1196Met Single submitter ⚠
- p.Val12Met Single submitter ⚠
- p.Val1313Leu Single submitter ⚠
- p.Val14Met Single submitter ⚠
- p.Val250Phe Single submitter ⚠
- p.Cys191Phe No assertion criteria prostate cancer ⚠
- p.Cys191Trp No assertion criteria prostate cancer ⚠
- p.Met228Ile No assertion criteria prostate cancer ⚠