PARG — 55 ClinVar variants
All ClinVar germline PARG variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 52 flagged for review →
2 Likely benign · 53 Uncertain significance
Full PARG gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 52
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 41
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PARG p.Ala349Gly Uncertain significance Single submitter
- PARG p.Ala563Thr Uncertain significance Single submitter
- PARG p.Ala586Ser Uncertain significance Single submitter
- PARG p.Ala967Gly Uncertain significance Single submitter
- PARG p.Arg490Gln Uncertain significance Single submitter
- PARG p.Arg717Gln Uncertain significance Single submitter
- PARG p.Arg800Cys Uncertain significance Single submitter
- PARG p.Arg800His Uncertain significance Single submitter
- PARG p.Arg803Gln Uncertain significance Single submitter
- PARG p.Arg816Gln Uncertain significance Single submitter
- PARG p.Arg816Trp Uncertain significance Single submitter
- PARG p.Arg854His Uncertain significance Single submitter
- PARG p.Arg880Lys Uncertain significance Single submitter
- PARG p.Arg934Gln Uncertain significance Single submitter
- PARG p.Asn545Lys Uncertain significance Single submitter
- PARG p.Asp949Val Uncertain significance Single submitter
- PARG p.Asp968Gly Uncertain significance Single submitter
- PARG p.Gln972Lys Uncertain significance Single submitter
- PARG p.Glu723Lys Uncertain significance Single submitter
- PARG p.Glu961Lys Uncertain significance Single submitter
- PARG p.His501Arg Uncertain significance Single submitter
- PARG p.His501Gln Uncertain significance Single submitter
- PARG p.Ile593Met Uncertain significance Single submitter
- PARG p.Ile612Val Uncertain significance Single submitter
- PARG p.Ile623Val Uncertain significance Single submitter
- PARG p.Ile887Leu Uncertain significance Single submitter
- PARG p.Ile911Val Uncertain significance Single submitter
- PARG p.Leu505Met Uncertain significance Single submitter
- PARG p.Leu538Val Uncertain significance Single submitter
- PARG p.Leu664Ser Uncertain significance Single submitter
- PARG p.Met649Val Uncertain significance Single submitter
- PARG p.Met733Leu Uncertain significance Single submitter
- PARG p.Pro673Leu Uncertain significance Single submitter
- PARG p.Ser375Asn Uncertain significance Single submitter
- PARG p.Ser534Asn Uncertain significance Single submitter
- PARG p.Ser670Leu Uncertain significance Single submitter
- PARG p.Thr721Pro Uncertain significance Single submitter
- PARG p.Thr793Ala Uncertain significance Single submitter
- PARG p.Thr945Ala Uncertain significance Single submitter
- PARG p.Val486Gly Uncertain significance Single submitter
- PARG p.Val822Ile Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- PARG p.Ala586Pro Uncertain significance Single submitter
- PARG p.Arg741His Uncertain significance Single submitter
- PARG p.Arg854Cys Uncertain significance Single submitter
- PARG p.His621Tyr Uncertain significance Single submitter
- PARG p.Ile824Met Uncertain significance Single submitter
- PARG p.Ile885Met Uncertain significance Single submitter
- PARG p.Met914Ile Uncertain significance Single submitter
- PARG p.Met914Thr Uncertain significance Single submitter
- PARG p.Phe547Leu Uncertain significance Single submitter
- PARG p.Thr945Ile Uncertain significance Single submitter
- PARG p.Tyr936Cys Uncertain significance Single submitter
All PARG variants
Likely benign 2
- c.1455+115464A>G Single submitter
- p.Leu923= Single submitter
Uncertain significance 53
- p.Ala349Gly Single submitter ⚠
- p.Ala563Thr Single submitter ⚠
- p.Ala586Pro Single submitter ⚠
- p.Ala586Ser Single submitter ⚠
- p.Ala967Gly Single submitter ⚠
- p.Arg490Gln Single submitter ⚠
- p.Arg717Gln Single submitter ⚠
- p.Arg741His Single submitter ⚠
- p.Arg800Cys Single submitter ⚠
- p.Arg800His Single submitter ⚠
- p.Arg803Gln Single submitter ⚠
- p.Arg816Gln Single submitter ⚠
- p.Arg816Trp Single submitter ⚠
- p.Arg854Cys Single submitter ⚠
- p.Arg854His Single submitter ⚠
- p.Arg880Lys Single submitter ⚠
- p.Arg934Gln Single submitter ⚠
- p.Asn545Lys Single submitter ⚠
- p.Asp949Val Single submitter ⚠
- p.Asp968Gly Single submitter ⚠
- p.Gln972Lys Single submitter ⚠
- p.Glu723Lys Single submitter ⚠
- p.Glu961Lys Single submitter ⚠
- p.His501Arg Single submitter ⚠
- p.His501Gln Single submitter ⚠
- p.His621Tyr Single submitter ⚠
- p.Ile593Met Single submitter ⚠
- p.Ile612Val Single submitter ⚠
- p.Ile623Val Single submitter ⚠
- p.Ile824Met Single submitter ⚠
- p.Ile885Met Single submitter ⚠
- p.Ile887Leu Single submitter ⚠
- p.Ile911Val Single submitter ⚠
- p.Leu505Met Single submitter ⚠
- p.Leu538Val Single submitter ⚠
- p.Leu664Ser Single submitter ⚠
- p.Met649Val Single submitter ⚠
- p.Met733Leu Single submitter ⚠
- p.Met914Ile Single submitter ⚠
- p.Met914Thr Single submitter ⚠
- p.Phe547Leu Single submitter ⚠
- p.Pro673Leu Single submitter ⚠
- p.Ser375Asn Single submitter ⚠
- p.Ser534Asn Single submitter ⚠
- p.Ser670Leu Single submitter ⚠
- p.Thr571Lys Single submitter
- p.Thr721Pro Single submitter ⚠
- p.Thr793Ala Single submitter ⚠
- p.Thr945Ala Single submitter ⚠
- p.Thr945Ile Single submitter ⚠
- p.Tyr936Cys Single submitter ⚠
- p.Val486Gly Single submitter ⚠
- p.Val822Ile Single submitter ⚠