PARL — 58 ClinVar variants
All ClinVar germline PARL variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 51 flagged for review →
2 Likely benign · 56 Uncertain significance
Full PARL gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 51
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 43
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PARL p.Ala223Val Uncertain significance Single submitter
- PARL p.Ala2Glu Uncertain significance Single submitter
- PARL p.Ala308Val Uncertain significance Single submitter
- PARL p.Arg190Gln Uncertain significance Single submitter
- PARL p.Arg190Trp Uncertain significance Single submitter
- PARL p.Arg58Gly Uncertain significance Single submitter
- PARL p.Arg63Gln Uncertain significance Single submitter
- PARL p.Arg76Thr Uncertain significance Single submitter
- PARL p.Asp141Ala Uncertain significance Single submitter
- PARL p.Asp150Glu Uncertain significance Single submitter
- PARL p.Cys111Tyr Uncertain significance Single submitter
- PARL p.Glu84Lys Uncertain significance Single submitter
- PARL p.Gly71Cys Uncertain significance Single submitter
- PARL p.Ile143Leu Uncertain significance Single submitter
- PARL p.Ile155Met Uncertain significance Single submitter
- PARL p.Ile155Phe Uncertain significance Single submitter
- PARL p.Ile299Val Uncertain significance Single submitter
- PARL p.Ile315Val Uncertain significance Single submitter
- PARL p.Leu162Pro Uncertain significance Single submitter
- PARL p.Leu274Phe Uncertain significance Single submitter
- PARL p.Leu296Arg Uncertain significance Single submitter
- PARL p.Leu336Pro Uncertain significance Single submitter
- PARL p.Lys373Gln Uncertain significance Single submitter
- PARL p.Lys55Arg Uncertain significance Single submitter
- PARL p.Met222Val Uncertain significance Single submitter
- PARL p.Phe329Cys Uncertain significance Single submitter
- PARL p.Phe43Ile Uncertain significance Single submitter
- PARL p.Pro208Ala Uncertain significance Single submitter
- PARL p.Pro302Leu Uncertain significance Single submitter
- PARL p.Pro359Leu Uncertain significance Single submitter
- PARL p.Pro92Leu Uncertain significance Single submitter
- PARL p.Pro92Ser Uncertain significance Single submitter
- PARL p.Ser142Gly Uncertain significance Single submitter
- PARL p.Ser215Gly Uncertain significance Single submitter
- PARL p.Ser65Leu Uncertain significance Single submitter
- PARL p.Ser97Asn Uncertain significance Single submitter
- PARL p.Thr105Ile Uncertain significance Single submitter
- PARL p.Thr170Ser Uncertain significance Single submitter
- PARL p.Thr289Pro Uncertain significance Single submitter
- PARL p.Trp3Ser Uncertain significance Single submitter
- PARL p.Tyr227Cys Uncertain significance Single submitter
- PARL p.Tyr348Phe Uncertain significance Single submitter
- PARL p.Ser77Asn Uncertain significance No assertion criteria
Predictors split 8
The independent predictors disagree with each other — read with care.
- PARL p.Ala297Gly Uncertain significance Single submitter
- PARL p.Arg269Ser Uncertain significance Single submitter
- PARL p.Ile298Val Uncertain significance Single submitter
- PARL p.Leu340Phe Uncertain significance Single submitter
- PARL p.Pro94Leu Uncertain significance Single submitter
- PARL p.Ser198Leu Uncertain significance Single submitter
- PARL p.Thr109Ile Uncertain significance Single submitter
- PARL p.Trp230Arg Uncertain significance Single submitter
All PARL variants
Uncertain significance 56
- p.Ala117Thr Single submitter
- p.Ala223Val Single submitter ⚠
- p.Ala297Gly Single submitter ⚠
- p.Ala2Glu Single submitter ⚠
- p.Ala308Val Single submitter ⚠
- p.Arg167Trp Single submitter
- p.Arg190Gln Single submitter ⚠
- p.Arg190Trp Single submitter ⚠
- p.Arg269Ser Single submitter ⚠
- p.Arg58Gly Single submitter ⚠
- p.Arg63Gln Single submitter ⚠
- p.Arg76Thr Single submitter ⚠
- p.Asp141Ala Single submitter ⚠
- p.Asp150Glu Single submitter ⚠
- p.Cys111Tyr Single submitter ⚠
- p.Glu84Lys Single submitter ⚠
- p.Gly271= Single submitter
- p.Gly52Arg Single submitter
- p.Gly71Cys Single submitter ⚠
- p.Ile143Leu Single submitter ⚠
- p.Ile155Met Single submitter ⚠
- p.Ile155Phe Single submitter ⚠
- p.Ile298Val Single submitter ⚠
- p.Ile299Val Single submitter ⚠
- p.Ile315Val Single submitter ⚠
- p.Leu162Pro Single submitter ⚠
- p.Leu274Phe Single submitter ⚠
- p.Leu296Arg Single submitter ⚠
- p.Leu336Pro Single submitter ⚠
- p.Leu340Phe Single submitter ⚠
- p.Lys373Gln Single submitter ⚠
- p.Lys55Arg Single submitter ⚠
- p.Met222Val Single submitter ⚠
- p.Phe329Cys Single submitter ⚠
- p.Phe43Ile Single submitter ⚠
- p.Pro208Ala Single submitter ⚠
- p.Pro302Leu Single submitter ⚠
- p.Pro359Leu Single submitter ⚠
- p.Pro92Leu Single submitter ⚠
- p.Pro92Ser Single submitter ⚠
- p.Pro94Leu Single submitter ⚠
- p.Ser142Gly Single submitter ⚠
- p.Ser198Leu Single submitter ⚠
- p.Ser215Gly Single submitter ⚠
- p.Ser65Leu Single submitter ⚠
- p.Ser97Asn Single submitter ⚠
- p.Thr105Ile Single submitter ⚠
- p.Thr109Ile Single submitter ⚠
- p.Thr170Ser Single submitter ⚠
- p.Thr289Pro Single submitter ⚠
- p.Trp230Arg Single submitter ⚠
- p.Trp344Leu Single submitter
- p.Trp3Ser Single submitter ⚠
- p.Tyr227Cys Single submitter ⚠
- p.Tyr348Phe Single submitter ⚠
- p.Ser77Asn No assertion criteria ⚠