PARP11 — 38 ClinVar variants
All ClinVar germline PARP11 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 36 flagged for review →
1 Likely benign · 37 Uncertain significance
Full PARP11 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 36
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 29
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PARP11 p.Ala186Ser Uncertain significance Single submitter
- PARP11 p.Ala242Val Uncertain significance Single submitter
- PARP11 p.Ala4Val Uncertain significance Single submitter
- PARP11 p.Arg163His Uncertain significance Single submitter
- PARP11 p.Arg165Gln Uncertain significance Single submitter
- PARP11 p.Arg239Gly Uncertain significance Single submitter
- PARP11 p.Arg246His Uncertain significance Single submitter
- PARP11 p.Arg268Pro Uncertain significance Single submitter
- PARP11 p.Arg268Trp Uncertain significance Single submitter
- PARP11 p.Asn70Ser Uncertain significance Single submitter
- PARP11 p.Cys215Arg Uncertain significance Single submitter
- PARP11 p.Glu14Val Uncertain significance Single submitter
- PARP11 p.Glu152Lys Uncertain significance Single submitter
- PARP11 p.Glu199Gln Uncertain significance Single submitter
- PARP11 p.Glu64Lys Uncertain significance Single submitter
- PARP11 p.His148Arg Uncertain significance Single submitter
- PARP11 p.His269Arg Uncertain significance Single submitter
- PARP11 p.Lys167Arg Uncertain significance Single submitter
- PARP11 p.Met161Val Uncertain significance Single submitter
- PARP11 p.Phe203Leu Uncertain significance Single submitter
- PARP11 p.Phe324Leu Uncertain significance Single submitter
- PARP11 p.Phe77Ser Uncertain significance Single submitter
- PARP11 p.Pro127Ser Uncertain significance Single submitter
- PARP11 p.Pro142Ser Uncertain significance Single submitter
- PARP11 p.Pro50Leu Uncertain significance Single submitter
- PARP11 p.Pro6Thr Uncertain significance Single submitter
- PARP11 p.Tyr138Cys Uncertain significance Single submitter
- PARP11 p.Val194Met Uncertain significance Single submitter
- PARP11 p.Val230Ala Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- PARP11 p.Arg102Cys Uncertain significance Single submitter
- PARP11 p.Cys311Ser Uncertain significance Single submitter
- PARP11 p.Gln101Pro Uncertain significance Single submitter
- PARP11 p.Gly302Arg Uncertain significance Single submitter
- PARP11 p.His227Tyr Uncertain significance Single submitter
- PARP11 p.Phe157Ile Uncertain significance Single submitter
- PARP11 p.Phe258Leu Uncertain significance Single submitter
All PARP11 variants
Likely benign 1
- p.Asn145Ser Single submitter
Uncertain significance 37
- p.Ala186Ser Single submitter ⚠
- p.Ala242Val Single submitter ⚠
- p.Ala4Val Single submitter ⚠
- p.Arg102Cys Single submitter ⚠
- p.Arg163His Single submitter ⚠
- p.Arg165Gln Single submitter ⚠
- p.Arg239Gly Single submitter ⚠
- p.Arg246His Single submitter ⚠
- p.Arg268Pro Single submitter ⚠
- p.Arg268Trp Single submitter ⚠
- p.Asn70Ser Single submitter ⚠
- p.Cys215Arg Single submitter ⚠
- p.Cys311Ser Single submitter ⚠
- p.Gln101Pro Single submitter ⚠
- p.Glu14Val Single submitter ⚠
- p.Glu152Lys Single submitter ⚠
- p.Glu199Gln Single submitter ⚠
- p.Glu64Lys Single submitter ⚠
- p.Gly302Arg Single submitter ⚠
- p.His148Arg Single submitter ⚠
- p.His227Tyr Single submitter ⚠
- p.His269Arg Single submitter ⚠
- p.Lys167Arg Single submitter ⚠
- p.Met161Val Single submitter ⚠
- p.Phe157Ile Single submitter ⚠
- p.Phe203Leu Single submitter ⚠
- p.Phe258Leu Single submitter ⚠
- p.Phe324Leu Single submitter ⚠
- p.Phe77Ser Single submitter ⚠
- p.Pro127Ser Single submitter ⚠
- p.Pro142Ser Single submitter ⚠
- p.Pro50Leu Single submitter ⚠
- p.Pro6Thr Single submitter ⚠
- p.Thr79Asn Single submitter
- p.Tyr138Cys Single submitter ⚠
- p.Val194Met Single submitter ⚠
- p.Val230Ala Single submitter ⚠