PARP12 — 89 ClinVar variants
All ClinVar germline PARP12 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 78 flagged for review →
3 Benign · 6 Likely benign · 80 Uncertain significance
Full PARP12 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 78
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 65
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PARP12 p.Ala102Thr Uncertain significance Single submitter
- PARP12 p.Ala348Thr Uncertain significance Single submitter
- PARP12 p.Ala356Thr Uncertain significance Single submitter
- PARP12 p.Ala556Val Uncertain significance Single submitter
- PARP12 p.Ala573Ser Uncertain significance Single submitter
- PARP12 p.Ala601Asp Uncertain significance Single submitter
- PARP12 p.Ala632Asp Uncertain significance Single submitter
- PARP12 p.Ala632Pro Uncertain significance Single submitter
- PARP12 p.Arg228Gly Uncertain significance Single submitter
- PARP12 p.Arg281Gln Uncertain significance Single submitter
- PARP12 p.Arg519Cys Uncertain significance Single submitter
- PARP12 p.Asn114Asp Uncertain significance Single submitter
- PARP12 p.Asn123Asp Uncertain significance Single submitter
- PARP12 p.Asn324Ser Uncertain significance Single submitter
- PARP12 p.Asp163Gly Uncertain significance Single submitter
- PARP12 p.Asp288Gly Uncertain significance Single submitter
- PARP12 p.Asp611Asn Uncertain significance Single submitter
- PARP12 p.Cys332Tyr Uncertain significance Single submitter
- PARP12 p.Cys457Arg Uncertain significance Single submitter
- PARP12 p.Gln287Leu Uncertain significance Single submitter
- PARP12 p.Glu139Gln Uncertain significance Single submitter
- PARP12 p.Gly164Ala Uncertain significance Single submitter
- PARP12 p.Gly251Arg Uncertain significance Single submitter
- PARP12 p.Gly386Asp Uncertain significance Single submitter
- PARP12 p.Gly422Ser Uncertain significance Single submitter
- PARP12 p.Gly553Arg Uncertain significance Single submitter
- PARP12 p.Gly592Ser Uncertain significance Single submitter
- PARP12 p.His158Tyr Uncertain significance Single submitter
- PARP12 p.His166Arg Uncertain significance Single submitter
- PARP12 p.His342Leu Uncertain significance Single submitter
- PARP12 p.His667Tyr Uncertain significance Single submitter
- PARP12 p.Ile226Val Uncertain significance Single submitter
- PARP12 p.Ile529Ser Uncertain significance Single submitter
- PARP12 p.Leu317Arg Uncertain significance Single submitter
- PARP12 p.Leu696Pro Uncertain significance Single submitter
- PARP12 p.Lys196Arg Uncertain significance Single submitter
- PARP12 p.Lys367Arg Uncertain significance Single submitter
- PARP12 p.Lys555Gln Uncertain significance Single submitter
- PARP12 p.Phe478Leu Uncertain significance Single submitter
- PARP12 p.Phe597Val Uncertain significance Single submitter
- PARP12 p.Pro149Leu Uncertain significance Single submitter
- PARP12 p.Pro249Ser Uncertain significance Single submitter
- PARP12 p.Pro460Ser Uncertain significance Single submitter
- PARP12 p.Pro465Ser Uncertain significance Single submitter
- PARP12 p.Pro479Ala Uncertain significance Single submitter
- PARP12 p.Pro481Arg Uncertain significance Single submitter
- PARP12 p.Pro658Leu Uncertain significance Single submitter
- PARP12 p.Pro658Ser Uncertain significance Single submitter
- PARP12 p.Ser491Cys Uncertain significance Single submitter
- PARP12 p.Ser504Asn Uncertain significance Single submitter
- PARP12 p.Thr225Ile Uncertain significance Single submitter
- PARP12 p.Thr252Ser Uncertain significance Single submitter
- PARP12 p.Thr354Ser Uncertain significance Single submitter
- PARP12 p.Thr469Met Uncertain significance Single submitter
- PARP12 p.Thr502Ile Uncertain significance Single submitter
- PARP12 p.Tyr183Cys Uncertain significance Single submitter
- PARP12 p.Tyr436Cys Uncertain significance Single submitter
- PARP12 p.Tyr450Cys Uncertain significance Single submitter
- PARP12 p.Tyr670Ser Uncertain significance Single submitter
- PARP12 p.Tyr677His Uncertain significance Single submitter
- PARP12 p.Val132Ile Uncertain significance Single submitter
- PARP12 p.Val397Leu Uncertain significance Single submitter
- PARP12 p.Val456Ile Uncertain significance Single submitter
- PARP12 p.Val628Ile Uncertain significance Single submitter
- PARP12 p.Val99Ile Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- PARP12 p.Thr120Ile Benign Multiple submitters
- PARP12 p.Arg228Ile Uncertain significance Single submitter
- PARP12 p.Arg281Trp Likely benign Single submitter
- PARP12 p.Arg300Gln Uncertain significance Single submitter
- PARP12 p.Arg560Trp Uncertain significance Single submitter
- PARP12 p.Arg599Gln Uncertain significance Single submitter
- PARP12 p.Glu390Lys Uncertain significance Single submitter
- PARP12 p.Gly554Glu Uncertain significance Single submitter
- PARP12 p.Phe627Leu Uncertain significance Single submitter
- PARP12 p.Ser405Gly Uncertain significance Single submitter
- PARP12 p.Thr616Met Uncertain significance Single submitter
- PARP12 p.Val468Met Uncertain significance Single submitter
- PARP12 p.Val557Met Uncertain significance Single submitter
All PARP12 variants
Benign 3
- p.Gly419= Multiple submitters
- p.Thr120Ile Multiple submitters ⚠
- p.Tyr351= Multiple submitters
Likely benign 6
- c.1498-5T>C Single submitter
- p.Ala568Thr Single submitter
- p.Arg281Trp Single submitter ⚠
- p.Asn645= Single submitter
- p.Thr396Met Single submitter
- p.Val408Leu Single submitter
Uncertain significance 80
- p.Ala102Thr Single submitter ⚠
- p.Ala348Thr Single submitter ⚠
- p.Ala356Thr Single submitter ⚠
- p.Ala556Val Single submitter ⚠
- p.Ala573Ser Single submitter ⚠
- p.Ala601Asp Single submitter ⚠
- p.Ala632Asp Single submitter ⚠
- p.Ala632Pro Single submitter ⚠
- p.Arg228Gly Single submitter ⚠
- p.Arg228Ile Single submitter ⚠
- p.Arg281Gln Single submitter ⚠
- p.Arg300Gln Single submitter ⚠
- p.Arg519Cys Single submitter ⚠
- p.Arg560Trp Single submitter ⚠
- p.Arg599Gln Single submitter ⚠
- p.Arg636His Single submitter
- p.Asn114Asp Single submitter ⚠
- p.Asn123Asp Single submitter ⚠
- p.Asn324Ser Single submitter ⚠
- p.Asp163Gly Single submitter ⚠
- p.Asp288Gly Single submitter ⚠
- p.Asp611Asn Single submitter ⚠
- p.Cys332Tyr Single submitter ⚠
- p.Cys457Arg Single submitter ⚠
- p.Gln287Leu Single submitter ⚠
- p.Glu139Gln Single submitter ⚠
- p.Glu390Lys Single submitter ⚠
- p.Gly164Ala Single submitter ⚠
- p.Gly214Cys Single submitter
- p.Gly251Arg Single submitter ⚠
- p.Gly386Asp Single submitter ⚠
- p.Gly422Ser Single submitter ⚠
- p.Gly553Arg Single submitter ⚠
- p.Gly554Glu Single submitter ⚠
- p.Gly592Ser Single submitter ⚠
- p.His158Tyr Single submitter ⚠
- p.His166Arg Single submitter ⚠
- p.His342Leu Single submitter ⚠
- p.His667Tyr Single submitter ⚠
- p.Ile226Val Single submitter ⚠
- p.Ile529Ser Single submitter ⚠
- p.Ile574Val Single submitter
- p.Leu317Arg Single submitter ⚠
- p.Leu696Pro Single submitter ⚠
- p.Lys196Arg Single submitter ⚠
- p.Lys367Arg Single submitter ⚠
- p.Lys555Gln Single submitter ⚠
- p.Phe478Leu Single submitter ⚠
- p.Phe597Val Single submitter ⚠
- p.Phe627Leu Single submitter ⚠
- p.Pro149Leu Single submitter ⚠
- p.Pro249Ser Single submitter ⚠
- p.Pro460Ser Single submitter ⚠
- p.Pro465Ser Single submitter ⚠
- p.Pro479Ala Single submitter ⚠
- p.Pro481Arg Single submitter ⚠
- p.Pro638Leu Single submitter
- p.Pro658Leu Single submitter ⚠
- p.Pro658Ser Single submitter ⚠
- p.Ser405Gly Single submitter ⚠
- p.Ser491Cys Single submitter ⚠
- p.Ser504Asn Single submitter ⚠
- p.Thr225Ile Single submitter ⚠
- p.Thr252Ser Single submitter ⚠
- p.Thr354Ser Single submitter ⚠
- p.Thr469Met Single submitter ⚠
- p.Thr502Ile Single submitter ⚠
- p.Thr616Met Single submitter ⚠
- p.Tyr183Cys Single submitter ⚠
- p.Tyr436Cys Single submitter ⚠
- p.Tyr450Cys Single submitter ⚠
- p.Tyr670Ser Single submitter ⚠
- p.Tyr677His Single submitter ⚠
- p.Val132Ile Single submitter ⚠
- p.Val397Leu Single submitter ⚠
- p.Val456Ile Single submitter ⚠
- p.Val468Met Single submitter ⚠
- p.Val557Met Single submitter ⚠
- p.Val628Ile Single submitter ⚠
- p.Val99Ile Single submitter ⚠