PARP15 — 70 ClinVar variants
All ClinVar germline PARP15 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 63 flagged for review →
2 Benign · 7 Likely benign · 61 Uncertain significance
Full PARP15 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 63
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 45
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PARP15 p.Ala169Gly Uncertain significance Single submitter
- PARP15 p.Ala169Val Uncertain significance Single submitter
- PARP15 p.Arg123Gly Uncertain significance Single submitter
- PARP15 p.Arg331Gln Uncertain significance Single submitter
- PARP15 p.Asn251His Uncertain significance Single submitter
- PARP15 p.Asn490Ser Uncertain significance Single submitter
- PARP15 p.Asp160Tyr Uncertain significance Single submitter
- PARP15 p.Asp253Asn Uncertain significance Single submitter
- PARP15 p.Asp361Glu Uncertain significance Single submitter
- PARP15 p.Asp383Gly Uncertain significance Single submitter
- PARP15 p.Asp426Asn Uncertain significance Single submitter
- PARP15 p.Asp458Gly Uncertain significance Single submitter
- PARP15 p.Gln115His Uncertain significance Single submitter
- PARP15 p.Glu146Gln Uncertain significance Single submitter
- PARP15 p.Gly118Glu Uncertain significance Single submitter
- PARP15 p.Gly302Ser Uncertain significance Single submitter
- PARP15 p.His491Arg Uncertain significance Single submitter
- PARP15 p.Ile202Val Uncertain significance Single submitter
- PARP15 p.Ile94Thr Uncertain significance Single submitter
- PARP15 p.Leu499Val Uncertain significance Single submitter
- PARP15 p.Lys291Gln Uncertain significance Single submitter
- PARP15 p.Lys461Glu Uncertain significance Single submitter
- PARP15 p.Met278Arg Uncertain significance Single submitter
- PARP15 p.Met544Ile Uncertain significance Single submitter
- PARP15 p.Phe259Cys Uncertain significance Single submitter
- PARP15 p.Pro131Leu Uncertain significance Single submitter
- PARP15 p.Pro131Ser Uncertain significance Single submitter
- PARP15 p.Pro271Ser Uncertain significance Single submitter
- PARP15 p.Pro277Thr Uncertain significance Single submitter
- PARP15 p.Pro417Thr Uncertain significance Single submitter
- PARP15 p.Pro450Leu Uncertain significance Single submitter
- PARP15 p.Pro450Ser Uncertain significance Single submitter
- PARP15 p.Ser232Asn Uncertain significance Single submitter
- PARP15 p.Ser290Cys Uncertain significance Single submitter
- PARP15 p.Ser402Thr Uncertain significance Single submitter
- PARP15 p.Ser536Gly Uncertain significance Single submitter
- PARP15 p.Ser75Leu Uncertain significance Single submitter
- PARP15 p.Thr178Ala Uncertain significance Single submitter
- PARP15 p.Thr325Ile Uncertain significance Single submitter
- PARP15 p.Thr437Ile Uncertain significance Single submitter
- PARP15 p.Trp180Arg Uncertain significance Single submitter
- PARP15 p.Tyr297His Uncertain significance Single submitter
- PARP15 p.Tyr520Cys Uncertain significance Single submitter
- PARP15 p.Val320Ala Uncertain significance Single submitter
- PARP15 p.Val378Ile Uncertain significance Single submitter
Predictors split 18
The independent predictors disagree with each other — read with care.
- PARP15 p.Leu241Ser Benign Multiple submitters
- PARP15 p.Cys351Tyr Uncertain significance Single submitter
- PARP15 p.Gln134Glu Uncertain significance Single submitter
- PARP15 p.Gly156Asp Uncertain significance Single submitter
- PARP15 p.Gly156Ser Uncertain significance Single submitter
- PARP15 p.Ile106Met Uncertain significance Single submitter
- PARP15 p.Ile313Thr Uncertain significance Single submitter
- PARP15 p.Ile528Met Uncertain significance Single submitter
- PARP15 p.Lys444Glu Uncertain significance Single submitter
- PARP15 p.Phe152Leu Likely benign Single submitter
- PARP15 p.Pro205Ser Uncertain significance Single submitter
- PARP15 p.Ser109Gly Uncertain significance Single submitter
- PARP15 p.Ser402Leu Uncertain significance Single submitter
- PARP15 p.Ser432Pro Uncertain significance Single submitter
- PARP15 p.Thr365Ile Uncertain significance Single submitter
- PARP15 p.Val168Met Uncertain significance Single submitter
- PARP15 p.Val384Gly Uncertain significance Single submitter
- PARP15 p.Val420Leu Uncertain significance Single submitter
All PARP15 variants
Benign 2
- p.Ala521Thr Multiple submitters
- p.Leu241Ser Multiple submitters ⚠
Likely benign 7
- p.Arg123Gln Single submitter
- p.Arg142Gln Single submitter
- p.Arg515Gln Single submitter
- p.Ile187Val Single submitter
- p.Ile455Val Single submitter
- p.Phe152Leu Single submitter ⚠
- p.Thr234Ala Single submitter
Uncertain significance 61
- p.Ala169Gly Single submitter ⚠
- p.Ala169Val Single submitter ⚠
- p.Arg123Gly Single submitter ⚠
- p.Arg331Gln Single submitter ⚠
- p.Asn251His Single submitter ⚠
- p.Asn490Ser Single submitter ⚠
- p.Asp160Tyr Single submitter ⚠
- p.Asp253Asn Single submitter ⚠
- p.Asp361Glu Single submitter ⚠
- p.Asp383Gly Single submitter ⚠
- p.Asp426Asn Single submitter ⚠
- p.Asp458Gly Single submitter ⚠
- p.Cys351Tyr Single submitter ⚠
- p.Gln115His Single submitter ⚠
- p.Gln134Glu Single submitter ⚠
- p.Glu146Gln Single submitter ⚠
- p.Gly118Glu Single submitter ⚠
- p.Gly156Asp Single submitter ⚠
- p.Gly156Ser Single submitter ⚠
- p.Gly302Ser Single submitter ⚠
- p.His491Arg Single submitter ⚠
- p.Ile106Met Single submitter ⚠
- p.Ile202Val Single submitter ⚠
- p.Ile313Thr Single submitter ⚠
- p.Ile528Met Single submitter ⚠
- p.Ile94Thr Single submitter ⚠
- p.Leu499Val Single submitter ⚠
- p.Lys291Gln Single submitter ⚠
- p.Lys444Glu Single submitter ⚠
- p.Lys461Glu Single submitter ⚠
- p.Met278Arg Single submitter ⚠
- p.Met544Ile Single submitter ⚠
- p.Phe259Cys Single submitter ⚠
- p.Pro131Leu Single submitter ⚠
- p.Pro131Ser Single submitter ⚠
- p.Pro205Ser Single submitter ⚠
- p.Pro271Ser Single submitter ⚠
- p.Pro277Thr Single submitter ⚠
- p.Pro417Thr Single submitter ⚠
- p.Pro450Leu Single submitter ⚠
- p.Pro450Ser Single submitter ⚠
- p.Ser109Gly Single submitter ⚠
- p.Ser232Asn Single submitter ⚠
- p.Ser290Cys Single submitter ⚠
- p.Ser402Leu Single submitter ⚠
- p.Ser402Thr Single submitter ⚠
- p.Ser432Pro Single submitter ⚠
- p.Ser536Gly Single submitter ⚠
- p.Ser75Leu Single submitter ⚠
- p.Thr178Ala Single submitter ⚠
- p.Thr325Ile Single submitter ⚠
- p.Thr365Ile Single submitter ⚠
- p.Thr437Ile Single submitter ⚠
- p.Trp180Arg Single submitter ⚠
- p.Tyr297His Single submitter ⚠
- p.Tyr520Cys Single submitter ⚠
- p.Val168Met Single submitter ⚠
- p.Val320Ala Single submitter ⚠
- p.Val378Ile Single submitter ⚠
- p.Val384Gly Single submitter ⚠
- p.Val420Leu Single submitter ⚠