PARP16 — 55 ClinVar variants
All ClinVar germline PARP16 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 50 flagged for review →
1 Benign · 2 Likely benign · 52 Uncertain significance
Full PARP16 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 50
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 42
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PARP16 p.Ala134Pro Uncertain significance Single submitter
- PARP16 p.Ala13Thr Uncertain significance Single submitter
- PARP16 p.Ala240Val Uncertain significance Single submitter
- PARP16 p.Ala30Val Uncertain significance Single submitter
- PARP16 p.Ala48Val Uncertain significance Single submitter
- PARP16 p.Ala60Glu Uncertain significance Single submitter
- PARP16 p.Arg145Gln Uncertain significance Single submitter
- PARP16 p.Arg239Gln Uncertain significance Single submitter
- PARP16 p.Arg49Cys Uncertain significance Single submitter
- PARP16 p.Asn165Ser Uncertain significance Single submitter
- PARP16 p.Asp51Ala Uncertain significance Single submitter
- PARP16 p.Asp77Gly Uncertain significance Single submitter
- PARP16 p.Glu11Asp Uncertain significance Single submitter
- PARP16 p.Glu216Lys Uncertain significance Single submitter
- PARP16 p.Glu70Gln Uncertain significance Single submitter
- PARP16 p.Gly180Ala Uncertain significance Single submitter
- PARP16 p.Gly5Asp Uncertain significance Single submitter
- PARP16 p.His168Gln Uncertain significance Single submitter
- PARP16 p.His198Tyr Uncertain significance Single submitter
- PARP16 p.Ile218Val Uncertain significance Single submitter
- PARP16 p.Ile235Thr Uncertain significance Single submitter
- PARP16 p.Leu191Val Uncertain significance Single submitter
- PARP16 p.Lys107Arg Uncertain significance Single submitter
- PARP16 p.Lys64Arg Uncertain significance Single submitter
- PARP16 p.Met17Ile Uncertain significance Single submitter
- PARP16 p.Phe138Ser Uncertain significance Single submitter
- PARP16 p.Pro221Leu Uncertain significance Single submitter
- PARP16 p.Pro252Thr Uncertain significance Single submitter
- PARP16 p.Pro276Ala Uncertain significance Single submitter
- PARP16 p.Pro44Ser Uncertain significance Single submitter
- PARP16 p.Ser175Phe Uncertain significance Single submitter
- PARP16 p.Ser175Tyr Uncertain significance Single submitter
- PARP16 p.Ser272Ala Uncertain significance Single submitter
- PARP16 p.Ser306Asn Uncertain significance Single submitter
- PARP16 p.Ser33Arg Uncertain significance Single submitter
- PARP16 p.Ser38Trp Uncertain significance Single submitter
- PARP16 p.Ser63Asn Uncertain significance Single submitter
- PARP16 p.Thr117Met Uncertain significance Single submitter
- PARP16 p.Thr141Ser Uncertain significance Single submitter
- PARP16 p.Trp317Leu Uncertain significance Single submitter
- PARP16 p.Tyr139Phe Uncertain significance Single submitter
- PARP16 p.Tyr271Asn Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- PARP16 p.Lys224Gln Uncertain significance Multiple submitters
- PARP16 p.Ala12Gly Uncertain significance Single submitter
- PARP16 p.Gly248Glu Uncertain significance Single submitter
- PARP16 p.Ile250Asn Uncertain significance Single submitter
- PARP16 p.Ile97Thr Uncertain significance Single submitter
- PARP16 p.Phe151Leu Uncertain significance Single submitter
- PARP16 p.Thr181Ala Uncertain significance Single submitter
- PARP16 p.Val214Met Uncertain significance Single submitter
All PARP16 variants
Benign 1
- p.Ala320= Single submitter
Likely benign 2
- p.Ala320Val Single submitter
- p.Ala45= Single submitter
Uncertain significance 52
- p.Lys224Gln Multiple submitters ⚠
- p.Ala12Gly Single submitter ⚠
- p.Ala134Pro Single submitter ⚠
- p.Ala13Thr Single submitter ⚠
- p.Ala240Val Single submitter ⚠
- p.Ala30Val Single submitter ⚠
- p.Ala48Val Single submitter ⚠
- p.Ala60Glu Single submitter ⚠
- p.Arg145Gln Single submitter ⚠
- p.Arg239Gln Single submitter ⚠
- p.Arg49Cys Single submitter ⚠
- p.Asn165Ser Single submitter ⚠
- p.Asp51Ala Single submitter ⚠
- p.Asp77Gly Single submitter ⚠
- p.Glu11Asp Single submitter ⚠
- p.Glu216Lys Single submitter ⚠
- p.Glu70Gln Single submitter ⚠
- p.Gly180Ala Single submitter ⚠
- p.Gly206Ser Single submitter
- p.Gly248Glu Single submitter ⚠
- p.Gly5Asp Single submitter ⚠
- p.His168Gln Single submitter ⚠
- p.His198Tyr Single submitter ⚠
- p.Ile218Val Single submitter ⚠
- p.Ile235Thr Single submitter ⚠
- p.Ile250Asn Single submitter ⚠
- p.Ile97Thr Single submitter ⚠
- p.Leu191Val Single submitter ⚠
- p.Lys107Arg Single submitter ⚠
- p.Lys64Arg Single submitter ⚠
- p.Met17Ile Single submitter ⚠
- p.Phe138Ser Single submitter ⚠
- p.Phe151Leu Single submitter ⚠
- p.Pro221Leu Single submitter ⚠
- p.Pro252Thr Single submitter ⚠
- p.Pro276Ala Single submitter ⚠
- p.Pro44Ser Single submitter ⚠
- p.Ser175Phe Single submitter ⚠
- p.Ser175Tyr Single submitter ⚠
- p.Ser272Ala Single submitter ⚠
- p.Ser306Asn Single submitter ⚠
- p.Ser33Arg Single submitter ⚠
- p.Ser38Trp Single submitter ⚠
- p.Ser63Asn Single submitter ⚠
- p.Ser92Ter Single submitter
- p.Thr117Met Single submitter ⚠
- p.Thr141Ser Single submitter ⚠
- p.Thr181Ala Single submitter ⚠
- p.Trp317Leu Single submitter ⚠
- p.Tyr139Phe Single submitter ⚠
- p.Tyr271Asn Single submitter ⚠
- p.Val214Met Single submitter ⚠