PARP2 — 74 ClinVar variants
All ClinVar germline PARP2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 67 flagged for review →
4 Benign · 3 Likely benign · 67 Uncertain significance
Full PARP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 67
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 50
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PARP2 c.202+13G>A Uncertain significance Single submitter
- PARP2 c.202+22C>T Uncertain significance Single submitter
- PARP2 c.202+37C>G Uncertain significance Single submitter
- PARP2 p.Ala14Thr Uncertain significance Single submitter
- PARP2 p.Ala323Ser Uncertain significance Single submitter
- PARP2 p.Ala355Thr Uncertain significance Single submitter
- PARP2 p.Ala433Thr Uncertain significance Single submitter
- PARP2 p.Ala509Val Uncertain significance Single submitter
- PARP2 p.Ala87Gly Uncertain significance Single submitter
- PARP2 p.Arg140Pro Uncertain significance Single submitter
- PARP2 p.Arg22Thr Uncertain significance Single submitter
- PARP2 p.Arg303His Uncertain significance Single submitter
- PARP2 p.Arg555His Uncertain significance Single submitter
- PARP2 p.Asn116Lys Uncertain significance Single submitter
- PARP2 p.Asn58Ser Uncertain significance Single submitter
- PARP2 p.Asp383Asn Uncertain significance Single submitter
- PARP2 p.Cys152Tyr Uncertain significance Single submitter
- PARP2 p.Cys289Arg Uncertain significance Single submitter
- PARP2 p.Cys289Ser Uncertain significance Single submitter
- PARP2 p.Cys42Tyr Uncertain significance Single submitter
- PARP2 p.Gln319Glu Uncertain significance Single submitter
- PARP2 p.Gln339Arg Uncertain significance Single submitter
- PARP2 p.Glu179Lys Uncertain significance Single submitter
- PARP2 p.Glu209Gln Uncertain significance Single submitter
- PARP2 p.Glu46Asp Uncertain significance Single submitter
- PARP2 p.Gly142Glu Uncertain significance Single submitter
- PARP2 p.His147Arg Uncertain significance Single submitter
- PARP2 p.His281Tyr Uncertain significance Single submitter
- PARP2 p.Ile331Leu Uncertain significance Single submitter
- PARP2 p.Leu412Pro Uncertain significance Single submitter
- PARP2 p.Lys180Asn Uncertain significance Single submitter
- PARP2 p.Lys230Gln Uncertain significance Single submitter
- PARP2 p.Lys367Arg Uncertain significance Single submitter
- PARP2 p.Lys48Thr Uncertain significance Single submitter
- PARP2 p.Met193Thr Uncertain significance Single submitter
- PARP2 p.Met286Thr Uncertain significance Single submitter
- PARP2 p.Met286Val Uncertain significance Single submitter
- PARP2 p.Met386Val Uncertain significance Single submitter
- PARP2 p.Phe181Leu Uncertain significance Single submitter
- PARP2 p.Phe403Ser Uncertain significance Single submitter
- PARP2 p.Pro297Ala Uncertain significance Single submitter
- PARP2 p.Pro80Ala Uncertain significance Single submitter
- PARP2 p.Ser417Tyr Uncertain significance Single submitter
- PARP2 p.Ser512Cys Uncertain significance Single submitter
- PARP2 p.Thr199Ser Uncertain significance Single submitter
- PARP2 p.Thr540Ile Uncertain significance Single submitter
- PARP2 p.Tyr349Cys Uncertain significance Single submitter
- PARP2 p.Val101Ile Uncertain significance Single submitter
- PARP2 p.Val150Met Uncertain significance Single submitter
- PARP2 p.Val235Ile Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- PARP2 p.Asp222Gly Benign Multiple submitters
- PARP2 p.Ala92Gly Uncertain significance Single submitter
- PARP2 p.Arg277Pro Uncertain significance Single submitter
- PARP2 p.Arg309Trp Uncertain significance Single submitter
- PARP2 p.Arg40His Uncertain significance Single submitter
- PARP2 p.Arg557Gln Uncertain significance Single submitter
- PARP2 p.Asn459Ser Uncertain significance Single submitter
- PARP2 p.Gln112Leu Uncertain significance Single submitter
- PARP2 p.Ile232Met Uncertain significance Single submitter
- PARP2 p.Ile272Thr Uncertain significance Single submitter
- PARP2 p.Leu307Arg Uncertain significance Single submitter
- PARP2 p.Leu473Val Uncertain significance Single submitter
- PARP2 p.Lys256Asn Uncertain significance Single submitter
- PARP2 p.Met105Val Uncertain significance Single submitter
- PARP2 p.Met453Ile Uncertain significance Single submitter
- PARP2 p.Pro185Leu Uncertain significance Single submitter
- PARP2 p.Tyr102Cys Uncertain significance Single submitter
All PARP2 variants
Benign 4
- p.Asp222Gly Multiple submitters ⚠
- p.Leu345= Multiple submitters
- p.Ser148Asn Multiple submitters
- p.Asn544= Single submitter
Likely benign 3
- p.Ala159= Single submitter
- p.Arg465His Single submitter
- p.Val516Ile Single submitter
Uncertain significance 67
- c.202+13G>A Single submitter ⚠
- c.202+22C>T Single submitter ⚠
- c.202+37C>G Single submitter ⚠
- p.Ala14Thr Single submitter ⚠
- p.Ala323Ser Single submitter ⚠
- p.Ala355Thr Single submitter ⚠
- p.Ala433Thr Single submitter ⚠
- p.Ala509Val Single submitter ⚠
- p.Ala87Gly Single submitter ⚠
- p.Ala92Gly Single submitter ⚠
- p.Arg140Pro Single submitter ⚠
- p.Arg22Thr Single submitter ⚠
- p.Arg277Pro Single submitter ⚠
- p.Arg303His Single submitter ⚠
- p.Arg309Trp Single submitter ⚠
- p.Arg40His Single submitter ⚠
- p.Arg555His Single submitter ⚠
- p.Arg557Gln Single submitter ⚠
- p.Asn116Lys Single submitter ⚠
- p.Asn459Ser Single submitter ⚠
- p.Asn58Ser Single submitter ⚠
- p.Asp383Asn Single submitter ⚠
- p.Cys152Tyr Single submitter ⚠
- p.Cys289Arg Single submitter ⚠
- p.Cys289Ser Single submitter ⚠
- p.Cys42Tyr Single submitter ⚠
- p.Gln112Leu Single submitter ⚠
- p.Gln319Glu Single submitter ⚠
- p.Gln339Arg Single submitter ⚠
- p.Glu179Lys Single submitter ⚠
- p.Glu209Gln Single submitter ⚠
- p.Glu46Asp Single submitter ⚠
- p.Gly142Glu Single submitter ⚠
- p.His147Arg Single submitter ⚠
- p.His281Tyr Single submitter ⚠
- p.His500Arg Single submitter
- p.Ile232Met Single submitter ⚠
- p.Ile272Thr Single submitter ⚠
- p.Ile331Leu Single submitter ⚠
- p.Leu307Arg Single submitter ⚠
- p.Leu412Pro Single submitter ⚠
- p.Leu473Val Single submitter ⚠
- p.Lys180Asn Single submitter ⚠
- p.Lys230Gln Single submitter ⚠
- p.Lys256Asn Single submitter ⚠
- p.Lys367Arg Single submitter ⚠
- p.Lys48Thr Single submitter ⚠
- p.Met105Val Single submitter ⚠
- p.Met193Thr Single submitter ⚠
- p.Met286Thr Single submitter ⚠
- p.Met286Val Single submitter ⚠
- p.Met386Val Single submitter ⚠
- p.Met453Ile Single submitter ⚠
- p.Phe181Leu Single submitter ⚠
- p.Phe403Ser Single submitter ⚠
- p.Pro185Leu Single submitter ⚠
- p.Pro297Ala Single submitter ⚠
- p.Pro80Ala Single submitter ⚠
- p.Ser417Tyr Single submitter ⚠
- p.Ser512Cys Single submitter ⚠
- p.Thr199Ser Single submitter ⚠
- p.Thr540Ile Single submitter ⚠
- p.Tyr102Cys Single submitter ⚠
- p.Tyr349Cys Single submitter ⚠
- p.Val101Ile Single submitter ⚠
- p.Val150Met Single submitter ⚠
- p.Val235Ile Single submitter ⚠