PARP3 — 100 ClinVar variants

All ClinVar germline PARP3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 78 flagged for review →

5 Benign · 13 Likely benign · 82 Uncertain significance

Full PARP3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 78

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 60

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 18

The independent predictors disagree with each other — read with care.

All PARP3 variants

Benign 5

p.Ala41Ser Multiple submitters
p.Arg47= Multiple submitters
p.Gly385Ser Multiple submitters ⚠
c.501+9G>A Single submitter
p.Pro5Leu Single submitter

Likely benign 13

p.Ile153= Multiple submitters
p.Ala41Thr Single submitter
p.Arg170Gly Single submitter
p.Arg44His Single submitter
p.Asp90Glu Single submitter
p.Gln363Arg Single submitter
p.Gly59Glu Single submitter
p.Pro479= Single submitter
p.Pro5Arg Single submitter
p.Ser331Pro Single submitter
p.Thr244Ala Single submitter
p.Thr307Met Single submitter
p.Thr96Ala Single submitter

Uncertain significance 82

p.Ala227Thr Single submitter ⚠
p.Ala290Val Single submitter ⚠
p.Ala295Asp Single submitter
p.Ala33Gly Single submitter ⚠
p.Ala35Thr Single submitter ⚠
p.Ala38Thr Single submitter ⚠
p.Ala471Val Single submitter ⚠
p.Arg103Cys Single submitter ⚠
p.Arg103His Single submitter ⚠
p.Arg130Gln Single submitter ⚠
p.Arg140Trp Single submitter ⚠
p.Arg179Gln Single submitter ⚠
p.Arg20Gln Single submitter ⚠
p.Arg20Trp Single submitter ⚠
p.Arg228Gln Single submitter ⚠
p.Arg30Cys Single submitter ⚠
p.Arg317Gln Single submitter ⚠
p.Arg379Gln Single submitter ⚠
p.Arg379Gly Single submitter ⚠
p.Arg44Cys Single submitter ⚠
p.Arg526His Single submitter ⚠
p.Arg93Cys Single submitter ⚠
p.Asn349Asp Single submitter ⚠
p.Asn362Lys Single submitter ⚠
p.Asp316Glu Single submitter ⚠
p.Gln340Ter Single submitter
p.Glu131Lys Single submitter ⚠
p.Glu154Gly Single submitter ⚠
p.Glu231Lys Single submitter ⚠
p.Glu251Asp Single submitter ⚠
p.Glu26Lys Single submitter ⚠
p.Glu76Lys Single submitter ⚠
p.Gly102Asp Single submitter ⚠
p.Gly242Val Single submitter ⚠
p.Gly247Asp Single submitter ⚠
p.Gly424Arg Single submitter ⚠
p.Gly428Asp Single submitter ⚠
p.Gly437Ala Single submitter ⚠
p.His256Gln Single submitter ⚠
p.His313Gln Single submitter ⚠
p.His451Pro Single submitter ⚠
p.Ile153Met Single submitter ⚠
p.Ile261Thr Single submitter ⚠
p.Ile292Met Single submitter ⚠
p.Ile292Thr Single submitter ⚠
p.Ile39Leu Single submitter ⚠
p.Ile401Val Single submitter ⚠
p.Ile427Val Single submitter ⚠
p.Ile470Thr Single submitter ⚠
p.Leu192Phe Single submitter ⚠
p.Leu236Val Single submitter ⚠
p.Leu329Pro Single submitter ⚠
p.Leu395Phe Single submitter ⚠
p.Leu399Phe Single submitter ⚠
p.Lys214Asn Single submitter ⚠
p.Lys337Gln Single submitter ⚠
p.Lys360Glu Single submitter ⚠
p.Lys421Gln Single submitter
p.Phe125Leu Single submitter ⚠
p.Phe125Ser Single submitter ⚠
p.Phe440Leu Single submitter ⚠
p.Phe510Val Single submitter
p.Pro3Leu Single submitter ⚠
p.Pro403Thr Single submitter ⚠
p.Pro479Arg Single submitter ⚠
p.Ser198Asn Single submitter ⚠
p.Ser222Arg Single submitter ⚠
p.Ser254Pro Single submitter
p.Ser31Phe Single submitter ⚠
p.Ser422Thr Single submitter ⚠
p.Ser461Cys Single submitter ⚠
p.Ser513Cys Single submitter ⚠
p.Ser56Asn Single submitter ⚠
p.Thr151Ile Single submitter ⚠
p.Thr396Ser Single submitter ⚠
p.Tyr515Cys Single submitter ⚠
p.Val107Ala Single submitter ⚠
p.Val173Leu Single submitter ⚠
p.Val173Met Single submitter ⚠
p.Val361Ala Single submitter ⚠
p.Val48Met Single submitter ⚠
p.Val493Met Single submitter ⚠