PARP9 — 102 ClinVar variants
All ClinVar germline PARP9 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 90 flagged for review →
2 Benign · 11 Likely benign · 89 Uncertain significance
Full PARP9 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 90
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 78
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PARP9 p.Asp795Glu Uncertain significance Multiple submitters
- PARP9 p.Tyr796Ser Uncertain significance Multiple submitters
- PARP9 c.49+10C>T Uncertain significance Single submitter
- PARP9 c.49+15C>T Uncertain significance Single submitter
- PARP9 c.49+21C>T Uncertain significance Single submitter
- PARP9 c.49+27T>C Uncertain significance Single submitter
- PARP9 p.Ala11Val Uncertain significance Single submitter
- PARP9 p.Ala314Gly Uncertain significance Single submitter
- PARP9 p.Ala331Val Uncertain significance Single submitter
- PARP9 p.Ala554Thr Uncertain significance Single submitter
- PARP9 p.Arg165Gln Uncertain significance Single submitter
- PARP9 p.Arg225Gln Uncertain significance Single submitter
- PARP9 p.Arg225Trp Uncertain significance Single submitter
- PARP9 p.Arg44His Uncertain significance Single submitter
- PARP9 p.Arg582Leu Uncertain significance Single submitter
- PARP9 p.Arg586Cys Uncertain significance Single submitter
- PARP9 p.Arg586His Uncertain significance Single submitter
- PARP9 p.Asn193Tyr Uncertain significance Single submitter
- PARP9 p.Asn245Ser Uncertain significance Single submitter
- PARP9 p.Asn275Ser Uncertain significance Single submitter
- PARP9 p.Asn42Lys Uncertain significance Single submitter
- PARP9 p.Asn488Ser Uncertain significance Single submitter
- PARP9 p.Asn514Thr Uncertain significance Single submitter
- PARP9 p.Asn52Ser Uncertain significance Single submitter
- PARP9 p.Asn743Asp Uncertain significance Single submitter
- PARP9 p.Asp247Gly Uncertain significance Single submitter
- PARP9 p.Asp795Gly Uncertain significance Single submitter
- PARP9 p.Gln157Arg Uncertain significance Single submitter
- PARP9 p.Gln595Pro Uncertain significance Single submitter
- PARP9 p.Gln738Arg Uncertain significance Single submitter
- PARP9 p.Glu494Lys Uncertain significance Single submitter
- PARP9 p.Glu560Val Uncertain significance Single submitter
- PARP9 p.Glu566Gln Uncertain significance Single submitter
- PARP9 p.Gly151Glu Uncertain significance Single submitter
- PARP9 p.Gly230Glu Uncertain significance Single submitter
- PARP9 p.His515Tyr Uncertain significance Single submitter
- PARP9 p.His740Tyr Uncertain significance Single submitter
- PARP9 p.Ile220Val Uncertain significance Single submitter
- PARP9 p.Ile291Val Uncertain significance Single submitter
- PARP9 p.Ile308Met Uncertain significance Single submitter
- PARP9 p.Ile31Val Uncertain significance Single submitter
- PARP9 p.Ile370Val Uncertain significance Single submitter
- PARP9 p.Ile38Leu Uncertain significance Single submitter
- PARP9 p.Ile440Met Uncertain significance Single submitter
- PARP9 p.Ile606Asn Uncertain significance Single submitter
- PARP9 p.Leu153His Uncertain significance Single submitter
- PARP9 p.Leu342Met Uncertain significance Single submitter
- PARP9 p.Leu395Ile Uncertain significance Single submitter
- PARP9 p.Leu723Pro Uncertain significance Single submitter
- PARP9 p.Lys139Arg Uncertain significance Single submitter
- PARP9 p.Lys335Glu Uncertain significance Single submitter
- PARP9 p.Lys404Arg Uncertain significance Single submitter
- PARP9 p.Lys430Thr Uncertain significance Single submitter
- PARP9 p.Lys470Gln Uncertain significance Single submitter
- PARP9 p.Lys603Asn Uncertain significance Single submitter
- PARP9 p.Lys716Gln Uncertain significance Single submitter
- PARP9 p.Met492Ile Uncertain significance Single submitter
- PARP9 p.Met492Val Uncertain significance Single submitter
- PARP9 p.Met563Thr Uncertain significance Single submitter
- PARP9 p.Met568Ile Uncertain significance Single submitter
- PARP9 p.Phe431Ser Uncertain significance Single submitter
- PARP9 p.Pro30Arg Uncertain significance Single submitter
- PARP9 p.Pro741Leu Uncertain significance Single submitter
- PARP9 p.Pro751Leu Uncertain significance Single submitter
- PARP9 p.Ser235Asn Uncertain significance Single submitter
- PARP9 p.Ser327Leu Uncertain significance Single submitter
- PARP9 p.Ser389Tyr Uncertain significance Single submitter
- PARP9 p.Ser456Asn Uncertain significance Single submitter
- PARP9 p.Ser69Cys Uncertain significance Single submitter
- PARP9 p.Ser71Ala Uncertain significance Single submitter
- PARP9 p.Thr295Met Uncertain significance Single submitter
- PARP9 p.Thr616Asn Uncertain significance Single submitter
- PARP9 p.Tyr674Cys Uncertain significance Single submitter
- PARP9 p.Val162Phe Uncertain significance Single submitter
- PARP9 p.Val298Ile Uncertain significance Single submitter
- PARP9 p.Val313Leu Uncertain significance Single submitter
- PARP9 p.Val429Ile Uncertain significance Single submitter
- PARP9 p.Val745Ala Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- PARP9 p.Ile551Thr Uncertain significance Multiple submitters
- PARP9 p.Thr616Ala Benign Multiple submitters
- PARP9 p.Arg165Trp Uncertain significance Single submitter
- PARP9 p.Gly138Ser Uncertain significance Single submitter
- PARP9 p.Gly739Ala Uncertain significance Single submitter
- PARP9 p.Ile402Thr Uncertain significance Single submitter
- PARP9 p.Ile565Thr Uncertain significance Single submitter
- PARP9 p.Leu261Val Uncertain significance Single submitter
- PARP9 p.Leu282Pro Uncertain significance Single submitter
- PARP9 p.Leu749Pro Uncertain significance Single submitter
- PARP9 p.Phe703Leu Uncertain significance Single submitter
- PARP9 p.Thr704Ile Uncertain significance Single submitter
All PARP9 variants
Benign 2
- p.Glu405Lys Multiple submitters
- p.Thr616Ala Multiple submitters ⚠
Likely benign 11
- p.Ala813Thr Single submitter
- p.Arg451Lys Single submitter
- p.Arg555Gln Single submitter
- p.Asn13Ser Single submitter
- p.Ile383Leu Single submitter
- p.Ile541Met Single submitter
- p.Ile754Val Single submitter
- p.Leu39Phe Single submitter
- p.Met375Val Single submitter
- p.Phe352Ser Single submitter
- p.Tyr441His Single submitter
Uncertain significance 89
- p.Asp795Glu Multiple submitters ⚠
- p.Ile551Thr Multiple submitters ⚠
- p.Tyr796Ser Multiple submitters ⚠
- c.49+10C>T Single submitter ⚠
- c.49+15C>T Single submitter ⚠
- c.49+21C>T Single submitter ⚠
- c.49+27T>C Single submitter ⚠
- p.Ala11Val Single submitter ⚠
- p.Ala314Gly Single submitter ⚠
- p.Ala331Val Single submitter ⚠
- p.Ala554Thr Single submitter ⚠
- p.Arg165Gln Single submitter ⚠
- p.Arg165Trp Single submitter ⚠
- p.Arg225Gln Single submitter ⚠
- p.Arg225Trp Single submitter ⚠
- p.Arg44His Single submitter ⚠
- p.Arg582Leu Single submitter ⚠
- p.Arg586Cys Single submitter ⚠
- p.Arg586His Single submitter ⚠
- p.Asn193Tyr Single submitter ⚠
- p.Asn245Ser Single submitter ⚠
- p.Asn275Ser Single submitter ⚠
- p.Asn42Lys Single submitter ⚠
- p.Asn488Ser Single submitter ⚠
- p.Asn514Thr Single submitter ⚠
- p.Asn52Ser Single submitter ⚠
- p.Asn743Asp Single submitter ⚠
- p.Asp247Gly Single submitter ⚠
- p.Asp795Gly Single submitter ⚠
- p.Gln157Arg Single submitter ⚠
- p.Gln595Pro Single submitter ⚠
- p.Gln738Arg Single submitter ⚠
- p.Glu494Lys Single submitter ⚠
- p.Glu560Val Single submitter ⚠
- p.Glu566Gln Single submitter ⚠
- p.Gly138Ser Single submitter ⚠
- p.Gly151Glu Single submitter ⚠
- p.Gly230Glu Single submitter ⚠
- p.Gly739Ala Single submitter ⚠
- p.His515Tyr Single submitter ⚠
- p.His740Tyr Single submitter ⚠
- p.Ile220Val Single submitter ⚠
- p.Ile291Val Single submitter ⚠
- p.Ile308Met Single submitter ⚠
- p.Ile31Val Single submitter ⚠
- p.Ile370Val Single submitter ⚠
- p.Ile38Leu Single submitter ⚠
- p.Ile402Thr Single submitter ⚠
- p.Ile440Met Single submitter ⚠
- p.Ile565Thr Single submitter ⚠
- p.Ile606Asn Single submitter ⚠
- p.Leu153His Single submitter ⚠
- p.Leu261Val Single submitter ⚠
- p.Leu282Pro Single submitter ⚠
- p.Leu342Met Single submitter ⚠
- p.Leu395Ile Single submitter ⚠
- p.Leu723Pro Single submitter ⚠
- p.Leu749Pro Single submitter ⚠
- p.Lys139Arg Single submitter ⚠
- p.Lys335Glu Single submitter ⚠
- p.Lys404Arg Single submitter ⚠
- p.Lys430Thr Single submitter ⚠
- p.Lys470Gln Single submitter ⚠
- p.Lys603Asn Single submitter ⚠
- p.Lys716Gln Single submitter ⚠
- p.Met492Ile Single submitter ⚠
- p.Met492Val Single submitter ⚠
- p.Met563Thr Single submitter ⚠
- p.Met568Ile Single submitter ⚠
- p.Phe431Ser Single submitter ⚠
- p.Phe703Leu Single submitter ⚠
- p.Pro30Arg Single submitter ⚠
- p.Pro741Leu Single submitter ⚠
- p.Pro751Leu Single submitter ⚠
- p.Ser235Asn Single submitter ⚠
- p.Ser327Leu Single submitter ⚠
- p.Ser389Tyr Single submitter ⚠
- p.Ser456Asn Single submitter ⚠
- p.Ser69Cys Single submitter ⚠
- p.Ser71Ala Single submitter ⚠
- p.Thr295Met Single submitter ⚠
- p.Thr616Asn Single submitter ⚠
- p.Thr704Ile Single submitter ⚠
- p.Tyr674Cys Single submitter ⚠
- p.Val162Phe Single submitter ⚠
- p.Val298Ile Single submitter ⚠
- p.Val313Leu Single submitter ⚠
- p.Val429Ile Single submitter ⚠
- p.Val745Ala Single submitter ⚠