Sugi Variant

Sugi Variant/PCGF2

PCGF2 — 324 ClinVar variants

All ClinVar germline PCGF2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 146 flagged for review →

1 Pathogenic/Likely pathogenic · 2 Likely pathogenic · 16 Conflicting · 21 Benign · 11 Benign/Likely benign · 125 Likely benign · 148 Uncertain significance

Full PCGF2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 146

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 9

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 82

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 55

The independent predictors disagree with each other — read with care.

All PCGF2 variants

Pathogenic/Likely pathogenic 1

Likely pathogenic 2

Conflicting classifications of pathogenicity 16

Benign 21

Benign/Likely benign 11

Likely benign 125

Uncertain significance 148