PCID2 — 35 ClinVar variants
All ClinVar germline PCID2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 30 flagged for review →
2 Benign · 1 Likely benign · 32 Uncertain significance
Full PCID2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 30
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 21
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PCID2 p.Ala297Val Uncertain significance Single submitter
- PCID2 p.Ala299Val Uncertain significance Single submitter
- PCID2 p.Arg116Gln Uncertain significance Single submitter
- PCID2 p.Arg242His Uncertain significance Single submitter
- PCID2 p.Asn7Thr Uncertain significance Single submitter
- PCID2 p.Asp225Asn Uncertain significance Single submitter
- PCID2 p.Asp354Asn Uncertain significance Single submitter
- PCID2 p.Asp356Tyr Uncertain significance Single submitter
- PCID2 p.Cys83Tyr Uncertain significance Single submitter
- PCID2 p.Ile377Val Uncertain significance Single submitter
- PCID2 p.Leu145Pro Uncertain significance Single submitter
- PCID2 p.Lys128Asn Uncertain significance Single submitter
- PCID2 p.Met370Val Uncertain significance Single submitter
- PCID2 p.Ser154Gly Uncertain significance Single submitter
- PCID2 p.Ser198Pro Uncertain significance Single submitter
- PCID2 p.Ser243Cys Uncertain significance Single submitter
- PCID2 p.Thr397Met Uncertain significance Single submitter
- PCID2 p.Tyr232Asp Uncertain significance Single submitter
- PCID2 p.Tyr322Ser Uncertain significance Single submitter
- PCID2 p.Val134Gly Uncertain significance Single submitter
- PCID2 p.Val373Leu Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- PCID2 p.Ala37Val Uncertain significance Single submitter
- PCID2 p.Arg242Cys Uncertain significance Single submitter
- PCID2 p.Arg93Gln Uncertain significance Single submitter
- PCID2 p.His33Arg Uncertain significance Single submitter
- PCID2 p.His33Tyr Uncertain significance Single submitter
- PCID2 p.His3Pro Uncertain significance Single submitter
- PCID2 p.Ile4Thr Uncertain significance Single submitter
- PCID2 p.Met250Val Uncertain significance Single submitter
- PCID2 p.Val286Met Uncertain significance Single submitter
All PCID2 variants
Benign 2
- p.Gly135= Multiple submitters
- c.1111-4G>A Single submitter
Likely benign 1
- p.His295Asn Single submitter
Uncertain significance 32
- p.Ala297Val Single submitter ⚠
- p.Ala299Val Single submitter ⚠
- p.Ala37Val Single submitter ⚠
- p.Ala94Thr Single submitter
- p.Arg116Gln Single submitter ⚠
- p.Arg242Cys Single submitter ⚠
- p.Arg242His Single submitter ⚠
- p.Arg93Gln Single submitter ⚠
- p.Asn7Thr Single submitter ⚠
- p.Asp225Asn Single submitter ⚠
- p.Asp354Asn Single submitter ⚠
- p.Asp356Tyr Single submitter ⚠
- p.Cys83Tyr Single submitter ⚠
- p.Glu15Lys Single submitter
- p.His33Arg Single submitter ⚠
- p.His33Tyr Single submitter ⚠
- p.His3Pro Single submitter ⚠
- p.Ile377Val Single submitter ⚠
- p.Ile4Thr Single submitter ⚠
- p.Leu145Pro Single submitter ⚠
- p.Lys128Asn Single submitter ⚠
- p.Met250Val Single submitter ⚠
- p.Met370Val Single submitter ⚠
- p.Ser154Gly Single submitter ⚠
- p.Ser198Pro Single submitter ⚠
- p.Ser243Cys Single submitter ⚠
- p.Thr397Met Single submitter ⚠
- p.Tyr232Asp Single submitter ⚠
- p.Tyr322Ser Single submitter ⚠
- p.Val134Gly Single submitter ⚠
- p.Val286Met Single submitter ⚠
- p.Val373Leu Single submitter ⚠