PCP4 — 7 ClinVar variants
All ClinVar germline PCP4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 6 flagged for review →
7 Uncertain significance
Full PCP4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 6
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 4
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 2
The independent predictors disagree with each other — read with care.
All PCP4 variants
Uncertain significance 7
- p.Arg4Gln Single submitter ⚠
- p.Asp35Gly Single submitter ⚠
- p.Gln27His Single submitter ⚠
- p.Glu28Lys Single submitter
- p.Gly6Val Single submitter ⚠
- p.Lys57Asn Single submitter ⚠
- p.Ser60Cys Single submitter ⚠