PDCD1LG2 — 41 ClinVar variants
All ClinVar germline PDCD1LG2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 38 flagged for review →
3 Likely benign · 38 Uncertain significance
Full PDCD1LG2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 38
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 30
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PDCD1LG2 p.Ala109Thr Uncertain significance Single submitter
- PDCD1LG2 p.Ala18Pro Uncertain significance Single submitter
- PDCD1LG2 p.Ala18Val Uncertain significance Single submitter
- PDCD1LG2 p.Ala205Thr Uncertain significance Single submitter
- PDCD1LG2 p.Ala242Gly Uncertain significance Single submitter
- PDCD1LG2 p.Ala54Thr Uncertain significance Single submitter
- PDCD1LG2 p.Gln91Glu Uncertain significance Single submitter
- PDCD1LG2 p.Glu71Lys Uncertain significance Single submitter
- PDCD1LG2 p.His88Arg Uncertain significance Single submitter
- PDCD1LG2 p.Ile126Met Uncertain significance Single submitter
- PDCD1LG2 p.Ile130Met Uncertain significance Single submitter
- PDCD1LG2 p.Ile130Thr Uncertain significance Single submitter
- PDCD1LG2 p.Ile232Thr Uncertain significance Single submitter
- PDCD1LG2 p.Ile273Val Uncertain significance Single submitter
- PDCD1LG2 p.Ile2Asn Uncertain significance Single submitter
- PDCD1LG2 p.Leu150Val Uncertain significance Single submitter
- PDCD1LG2 p.Leu247His Uncertain significance Single submitter
- PDCD1LG2 p.Leu40Val Uncertain significance Single submitter
- PDCD1LG2 p.Leu6Ile Uncertain significance Single submitter
- PDCD1LG2 p.Lys132Asn Uncertain significance Single submitter
- PDCD1LG2 p.Lys255Glu Uncertain significance Single submitter
- PDCD1LG2 p.Lys259Glu Uncertain significance Single submitter
- PDCD1LG2 p.Lys259Thr Uncertain significance Single submitter
- PDCD1LG2 p.Met7Thr Uncertain significance Single submitter
- PDCD1LG2 p.Pro185Leu Uncertain significance Single submitter
- PDCD1LG2 p.Pro215His Uncertain significance Single submitter
- PDCD1LG2 p.Pro215Ser Uncertain significance Single submitter
- PDCD1LG2 p.Thr116Ile Uncertain significance Single submitter
- PDCD1LG2 p.Thr56Ile Uncertain significance Single submitter
- PDCD1LG2 p.Tyr100Ser Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- PDCD1LG2 p.Ala57Pro Uncertain significance Single submitter
- PDCD1LG2 p.Gln144Leu Uncertain significance Single submitter
- PDCD1LG2 p.Gly147Asp Uncertain significance Single submitter
- PDCD1LG2 p.Ile104Ser Uncertain significance Single submitter
- PDCD1LG2 p.Ile55Thr Uncertain significance Single submitter
- PDCD1LG2 p.Thr203Pro Uncertain significance Single submitter
- PDCD1LG2 p.Tyr148Asn Uncertain significance Single submitter
- PDCD1LG2 p.Val153Ala Uncertain significance Single submitter
All PDCD1LG2 variants
Likely benign 3
- p.Ile55Leu Single submitter
- p.Pro81Ser Single submitter
- p.Val199Met Single submitter
Uncertain significance 38
- p.Ala109Thr Single submitter ⚠
- p.Ala18Pro Single submitter ⚠
- p.Ala18Val Single submitter ⚠
- p.Ala205Thr Single submitter ⚠
- p.Ala242Gly Single submitter ⚠
- p.Ala54Thr Single submitter ⚠
- p.Ala57Pro Single submitter ⚠
- p.Gln144Leu Single submitter ⚠
- p.Gln91Glu Single submitter ⚠
- p.Glu71Lys Single submitter ⚠
- p.Gly147Asp Single submitter ⚠
- p.His88Arg Single submitter ⚠
- p.Ile104Ser Single submitter ⚠
- p.Ile126Met Single submitter ⚠
- p.Ile130Met Single submitter ⚠
- p.Ile130Thr Single submitter ⚠
- p.Ile232Thr Single submitter ⚠
- p.Ile273Val Single submitter ⚠
- p.Ile2Asn Single submitter ⚠
- p.Ile55Thr Single submitter ⚠
- p.Leu150Val Single submitter ⚠
- p.Leu247His Single submitter ⚠
- p.Leu40Val Single submitter ⚠
- p.Leu6Ile Single submitter ⚠
- p.Lys132Asn Single submitter ⚠
- p.Lys255Glu Single submitter ⚠
- p.Lys259Glu Single submitter ⚠
- p.Lys259Thr Single submitter ⚠
- p.Met7Thr Single submitter ⚠
- p.Pro185Leu Single submitter ⚠
- p.Pro215His Single submitter ⚠
- p.Pro215Ser Single submitter ⚠
- p.Thr116Ile Single submitter ⚠
- p.Thr203Pro Single submitter ⚠
- p.Thr56Ile Single submitter ⚠
- p.Tyr100Ser Single submitter ⚠
- p.Tyr148Asn Single submitter ⚠
- p.Val153Ala Single submitter ⚠