PDCD2L — 64 ClinVar variants
All ClinVar germline PDCD2L variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 59 flagged for review →
4 Likely benign · 60 Uncertain significance
Full PDCD2L gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 59
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 50
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PDCD2L p.Ala111Val Uncertain significance Single submitter
- PDCD2L p.Ala174Thr Uncertain significance Single submitter
- PDCD2L p.Ala175Val Uncertain significance Single submitter
- PDCD2L p.Ala258Val Uncertain significance Single submitter
- PDCD2L p.Ala38Ser Uncertain significance Single submitter
- PDCD2L p.Ala44Ser Uncertain significance Single submitter
- PDCD2L p.Ala81Thr Uncertain significance Single submitter
- PDCD2L p.Arg161Pro Uncertain significance Single submitter
- PDCD2L p.Arg166Cys Uncertain significance Single submitter
- PDCD2L p.Arg51Pro Uncertain significance Single submitter
- PDCD2L p.Asn116Lys Uncertain significance Single submitter
- PDCD2L p.Asp110Asn Uncertain significance Single submitter
- PDCD2L p.Asp235Gly Uncertain significance Single submitter
- PDCD2L p.Cys329Trp Uncertain significance Single submitter
- PDCD2L p.Cys64Gly Uncertain significance Single submitter
- PDCD2L p.Cys82Phe Uncertain significance Single submitter
- PDCD2L p.Gln349Lys Uncertain significance Single submitter
- PDCD2L p.Glu218Lys Uncertain significance Single submitter
- PDCD2L p.Gly11Ser Uncertain significance Single submitter
- PDCD2L p.Gly19Ala Uncertain significance Single submitter
- PDCD2L p.Gly19Ser Uncertain significance Single submitter
- PDCD2L p.Gly246Arg Uncertain significance Single submitter
- PDCD2L p.Gly25Val Uncertain significance Single submitter
- PDCD2L p.Gly271Arg Uncertain significance Single submitter
- PDCD2L p.Gly68Asp Uncertain significance Single submitter
- PDCD2L p.His18Gln Uncertain significance Single submitter
- PDCD2L p.Ile220Thr Uncertain significance Single submitter
- PDCD2L p.Leu167Gln Uncertain significance Single submitter
- PDCD2L p.Leu172Gln Uncertain significance Single submitter
- PDCD2L p.Leu302Arg Uncertain significance Single submitter
- PDCD2L p.Lys6Asn Uncertain significance Single submitter
- PDCD2L p.Met303Arg Uncertain significance Single submitter
- PDCD2L p.Pro16Arg Uncertain significance Single submitter
- PDCD2L p.Pro55Arg Uncertain significance Single submitter
- PDCD2L p.Pro65Leu Uncertain significance Single submitter
- PDCD2L p.Pro65Ser Uncertain significance Single submitter
- PDCD2L p.Pro70Leu Uncertain significance Single submitter
- PDCD2L p.Ser209Asn Uncertain significance Single submitter
- PDCD2L p.Ser245Asn Uncertain significance Single submitter
- PDCD2L p.Ser270Arg Uncertain significance Single submitter
- PDCD2L p.Ser270Asn Uncertain significance Single submitter
- PDCD2L p.Thr159Ile Uncertain significance Single submitter
- PDCD2L p.Thr241Asn Uncertain significance Single submitter
- PDCD2L p.Thr28Asn Uncertain significance Single submitter
- PDCD2L p.Thr340Pro Uncertain significance Single submitter
- PDCD2L p.Trp158Arg Uncertain significance Single submitter
- PDCD2L p.Val202Ile Uncertain significance Single submitter
- PDCD2L p.Val4Phe Uncertain significance Single submitter
- PDCD2L p.Val77Leu Uncertain significance Single submitter
- PDCD2L p.Val8Met Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- PDCD2L p.Ala2Val Uncertain significance Single submitter
- PDCD2L p.Arg256Gln Uncertain significance Single submitter
- PDCD2L p.Asp122Tyr Uncertain significance Single submitter
- PDCD2L p.Asp351Asn Uncertain significance Single submitter
- PDCD2L p.Ile264Phe Uncertain significance Single submitter
- PDCD2L p.Phe78Leu Uncertain significance Single submitter
- PDCD2L p.Pro45Ser Uncertain significance Single submitter
- PDCD2L p.Pro7Leu Uncertain significance Single submitter
- PDCD2L p.Ser69Phe Uncertain significance Single submitter
All PDCD2L variants
Likely benign 4
- p.Gln295Arg Single submitter
- p.Ile242Val Single submitter
- p.Pro231Ser Single submitter
- p.Thr249Met Single submitter
Uncertain significance 60
- p.Ala111Val Single submitter ⚠
- p.Ala174Thr Single submitter ⚠
- p.Ala175Val Single submitter ⚠
- p.Ala258Val Single submitter ⚠
- p.Ala2Val Single submitter ⚠
- p.Ala38Ser Single submitter ⚠
- p.Ala44Ser Single submitter ⚠
- p.Ala81Thr Single submitter ⚠
- p.Arg161Pro Single submitter ⚠
- p.Arg166Cys Single submitter ⚠
- p.Arg256Gln Single submitter ⚠
- p.Arg51Pro Single submitter ⚠
- p.Asn116Lys Single submitter ⚠
- p.Asp110Asn Single submitter ⚠
- p.Asp122Tyr Single submitter ⚠
- p.Asp235Gly Single submitter ⚠
- p.Asp351Asn Single submitter ⚠
- p.Cys329Trp Single submitter ⚠
- p.Cys64Gly Single submitter ⚠
- p.Cys82Phe Single submitter ⚠
- p.Gln349Lys Single submitter ⚠
- p.Glu218Lys Single submitter ⚠
- p.Gly11Ser Single submitter ⚠
- p.Gly19Ala Single submitter ⚠
- p.Gly19Ser Single submitter ⚠
- p.Gly246Arg Single submitter ⚠
- p.Gly25Val Single submitter ⚠
- p.Gly271Arg Single submitter ⚠
- p.Gly68Asp Single submitter ⚠
- p.His18Gln Single submitter ⚠
- p.Ile220Thr Single submitter ⚠
- p.Ile264Phe Single submitter ⚠
- p.Leu167Gln Single submitter ⚠
- p.Leu172Gln Single submitter ⚠
- p.Leu302Arg Single submitter ⚠
- p.Lys6Asn Single submitter ⚠
- p.Met303Arg Single submitter ⚠
- p.Phe78Leu Single submitter ⚠
- p.Pro16Arg Single submitter ⚠
- p.Pro352Thr Single submitter
- p.Pro45Ser Single submitter ⚠
- p.Pro55Arg Single submitter ⚠
- p.Pro65Leu Single submitter ⚠
- p.Pro65Ser Single submitter ⚠
- p.Pro70Leu Single submitter ⚠
- p.Pro7Leu Single submitter ⚠
- p.Ser209Asn Single submitter ⚠
- p.Ser245Asn Single submitter ⚠
- p.Ser270Arg Single submitter ⚠
- p.Ser270Asn Single submitter ⚠
- p.Ser69Phe Single submitter ⚠
- p.Thr159Ile Single submitter ⚠
- p.Thr241Asn Single submitter ⚠
- p.Thr28Asn Single submitter ⚠
- p.Thr340Pro Single submitter ⚠
- p.Trp158Arg Single submitter ⚠
- p.Val202Ile Single submitter ⚠
- p.Val4Phe Single submitter ⚠
- p.Val77Leu Single submitter ⚠
- p.Val8Met Single submitter ⚠