PDCD4 — 44 ClinVar variants
All ClinVar germline PDCD4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 42 flagged for review →
2 Benign · 42 Uncertain significance
Full PDCD4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 42
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 32
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PDCD4 p.Ala84Thr Uncertain significance Single submitter
- PDCD4 p.Arg310Cys Uncertain significance Single submitter
- PDCD4 p.Asn410Ser Uncertain significance Single submitter
- PDCD4 p.Asp144His Uncertain significance Single submitter
- PDCD4 p.Asp246Val Uncertain significance Single submitter
- PDCD4 p.Asp287Gly Uncertain significance Single submitter
- PDCD4 p.Gln173Lys Uncertain significance Single submitter
- PDCD4 p.Gln290Glu Uncertain significance Single submitter
- PDCD4 p.Gln322Arg Uncertain significance Single submitter
- PDCD4 p.Glu411Gly Uncertain significance Single submitter
- PDCD4 p.Gly316Asp Uncertain significance Single submitter
- PDCD4 p.His361Arg Uncertain significance Single submitter
- PDCD4 p.Ile331Val Uncertain significance Single submitter
- PDCD4 p.Ile344Lys Uncertain significance Single submitter
- PDCD4 p.Leu100Met Uncertain significance Single submitter
- PDCD4 p.Leu260Phe Uncertain significance Single submitter
- PDCD4 p.Leu340Pro Uncertain significance Single submitter
- PDCD4 p.Leu446Arg Uncertain significance Single submitter
- PDCD4 p.Lys283Arg Uncertain significance Single submitter
- PDCD4 p.Lys352Gln Uncertain significance Single submitter
- PDCD4 p.Ser378Gly Uncertain significance Single submitter
- PDCD4 p.Ser424Cys Uncertain significance Single submitter
- PDCD4 p.Ser76Leu Uncertain significance Single submitter
- PDCD4 p.Ser80Ile Uncertain significance Single submitter
- PDCD4 p.Thr169Lys Uncertain significance Single submitter
- PDCD4 p.Thr233Ile Uncertain significance Single submitter
- PDCD4 p.Thr254Ser Uncertain significance Single submitter
- PDCD4 p.Thr375Ala Uncertain significance Single submitter
- PDCD4 p.Thr90Ser Uncertain significance Single submitter
- PDCD4 p.Trp315Gly Uncertain significance Single submitter
- PDCD4 p.Tyr365Phe Uncertain significance Single submitter
- PDCD4 p.Tyr405Cys Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- PDCD4 p.Ala118Val Uncertain significance Single submitter
- PDCD4 p.Arg428Trp Uncertain significance Single submitter
- PDCD4 p.Arg61Thr Uncertain significance Single submitter
- PDCD4 p.Arg69Trp Uncertain significance Single submitter
- PDCD4 p.Asp70Gly Uncertain significance Single submitter
- PDCD4 p.Cys288Tyr Uncertain significance Single submitter
- PDCD4 p.Met187Ile Uncertain significance Single submitter
- PDCD4 p.Met333Ile Uncertain significance Single submitter
- PDCD4 p.Ser323Phe Uncertain significance Single submitter
- PDCD4 p.Tyr409Cys Uncertain significance Single submitter
All PDCD4 variants
Uncertain significance 42
- p.Ala118Val Single submitter ⚠
- p.Ala84Thr Single submitter ⚠
- p.Arg310Cys Single submitter ⚠
- p.Arg428Trp Single submitter ⚠
- p.Arg61Thr Single submitter ⚠
- p.Arg69Trp Single submitter ⚠
- p.Asn410Ser Single submitter ⚠
- p.Asp144His Single submitter ⚠
- p.Asp246Val Single submitter ⚠
- p.Asp287Gly Single submitter ⚠
- p.Asp70Gly Single submitter ⚠
- p.Cys288Tyr Single submitter ⚠
- p.Gln173Lys Single submitter ⚠
- p.Gln290Glu Single submitter ⚠
- p.Gln322Arg Single submitter ⚠
- p.Glu411Gly Single submitter ⚠
- p.Gly316Asp Single submitter ⚠
- p.His361Arg Single submitter ⚠
- p.Ile331Val Single submitter ⚠
- p.Ile344Lys Single submitter ⚠
- p.Leu100Met Single submitter ⚠
- p.Leu260Phe Single submitter ⚠
- p.Leu340Pro Single submitter ⚠
- p.Leu446Arg Single submitter ⚠
- p.Lys283Arg Single submitter ⚠
- p.Lys352Gln Single submitter ⚠
- p.Met187Ile Single submitter ⚠
- p.Met333Ile Single submitter ⚠
- p.Ser323Phe Single submitter ⚠
- p.Ser378Gly Single submitter ⚠
- p.Ser424Cys Single submitter ⚠
- p.Ser76Leu Single submitter ⚠
- p.Ser80Ile Single submitter ⚠
- p.Thr169Lys Single submitter ⚠
- p.Thr233Ile Single submitter ⚠
- p.Thr254Ser Single submitter ⚠
- p.Thr375Ala Single submitter ⚠
- p.Thr90Ser Single submitter ⚠
- p.Trp315Gly Single submitter ⚠
- p.Tyr365Phe Single submitter ⚠
- p.Tyr405Cys Single submitter ⚠
- p.Tyr409Cys Single submitter ⚠